yog dab tsiUrsodeoxycholic acid hmoov?
Ursodeoxycholic acid yog ib qho tseem ceeb raw khoom rau tauroursodeoxycholic acid, ursodeoxycholic acid ntsiav tshuaj, ursodeoxycholic acid capsules thiab lwm yam tshuaj. Vim muaj cov teebmeem kev kho mob ntawm UDCA ntawm ntau yam kab mob, raws li tus neeg muag khoom ntawm UDCA hmoov raw cov ntaub ntawv, peb tau cog lus los muab cov khoom lag luam zoo kom tau raws li kev lag luam kws tshuaj cov cai rau kev kho mob cholestasis.
UDCA yog hydrophilic dihydroxybile acid. Nws cov txheej txheem ntawm kev ua haujlwm suav nrog kev txhawb nqa kev tso tawm ntawm endogenous bile acids, tiv thaiv hepatocytes thiab cov kua tsib lub hlwb, inhibiting hepatocyte apoptosis, thiab lwm yam, yog li txhim kho daim siab ua haujlwm, thiab muaj kev tiv thaiv kab mob thiab kev tiv thaiv Cell thiab lwm yam teebmeem.
Peb cov ntaub ntawv UDCA raw khoom yog npaj los ntawm cov tshuaj synthesis. Cov ntaub ntawv tseem ceeb suav nrog cholic acid (CA), hyodeoxycholic acid (HDCA), thiab chenodeoxycholic acid (CDCA) los ntawm cov kua tsib ntawm nyuj, npua, qaib, ducks thiab lwm yam tsiaj. Txoj kev no muaj cov cuab yeej tsim khoom ruaj khov thiab tswj tau zoo, thiab tuaj yeem ua tau raws li kev lag luam xav tau.
Lub cev thiab tshuaj muaj zog
Lub npe tshuaj ntawm UDCA yog 3, 7 -dihydroxy-5 -cholestane-24-acid. Nws yog ib qho tsis muaj zog acidic compound. Daim ntawv khij yog feem ntau insoluble hauv dej, thaum daim ntawv dissociated muaj sib txawv solubility nyob ntawm tus nqi pH ntawm cov kuab tshuaj. . Nws cov molecule muaj cov yam ntxwv amphiphilic. Raws li tus nqi pH nce, cov carboxylic acid sab chains maj mam dissociate, tsim ib tug yam ntxwv feature nrog ib tug polar taub hau thiab ib tug hydrophobic nto.
Pharmacokinetics (yuav ua li casUrsodiolua haujlwm)
Tom qab nkag mus rau hauv txoj hnyuv, tsuas yog ib feem me me ntawm UDCA nkag mus rau hauv cov quav, thiab feem ntau ntawm nws tau rov qab los ntawm txoj hnyuv thiab rov qab mus rau lub siab los ntawm cov hlab ntsha portal. Feem ntau ntawm cov reabsorbed UDCA yuav rov qab los ntawm daim siab hlwb thiab ua lub luag haujlwm dua hauv daim siab hlwb. Tsis tas li ntawd, UDCA kuj tau sib koom ua ke los ntawm tus tswv tsev thiab cov hnyuv, yog nyob hauv zos faib rau hauv lub siab-biliary-plab hnyuv system los ntawm enterohepatic ncig, thiab nws thiaj li tawm hauv cov quav. Vim nws cov yam ntxwv tshwj xeeb, UDCA tuaj yeem muaj lub sijhawm nyob ntev hauv lub cev, nrog rau ib nrab-lub neej ntawm 3.5 txog 5.8 hnub, yog li ua kom nws cov txiaj ntsig kho tau zoo.
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ursodeoxycholic acid siv rau dab tsi?
Raws li tus neeg muag khoom ntawm UDCA hmoov, KINTAI paub zoo txog qhov tseem ceeb thiab ntau hom kev ua haujlwm ntawm API no.
Paub meej yog raws li nram no:
Txheej txheem cej luam: actionursodeoxycholic acid mechanism ntawm kev txiav txim
1. Txhawb cov kua tsib kua qaub thiab inhibit nws reabsorption;
2. Antagonize hydrophobic bile acid cytotoxicity thiab tiv thaiv daim siab hlwb;
3. Tshem tawm cov dawb radicals, tiv thaiv oxidation, tswj kev tiv thaiv kab mob, thiab inhibit o.
Txhawb lub siab regeneration:
Ursodeoxycholic acid txhawb nqa lub siab rov tsim dua tshiab thiab pab txo lub siab fibrosis los ntawm kev ua kom tus ID1-WNT2/hepatocyte growth factor pathway. Lub peev xwm ntawm daim siab yog qhov tseem ceeb rau kev tswj lub siab kev noj qab haus huv thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv fibrosis thiab daim siab puas.
Txo cov roj cholesterol:
Ursodiol tuaj yeem txo cov roj cholesterol kom zoo los ntawm kev tawm tswv yim tsis zoo ntawm cov txheej txheem kev tswj hwm, thiab tau pom tias muaj txiaj ntsig zoo hauv kev kho mob gallbladder polypoidal polyreticular cholesterol.
Hloov cov kua tsib acid tivthaiv:
Raws li hydrophilic bile acid, ursodeoxycholic acid muaj txiaj ntsig zoo rau cov kua tsib tso tawm, yog li txhim kho cholestasis. Nws qhov xwm txheej hydrophilic ua rau nws tsim nyog rau kev thauj mus los thiab lwm yam txheej txheem physiological, thiab yog qhov tseem ceeb rau lub cev muaj pes tsawg leeg ntawm cov kua tsib.
Lipid-txo cov nyhuv:
Cov kev tshawb fawb tau pom tias Udca Powder tuaj yeem txhawb nqa beta oxidation ntawm cov roj fatty acids dawb hauv daim siab ntawm cov nas rog rog, muaj kev kho mob rau cov kab mob uas tsis yog-alcoholic fatty siab, thiab muaj kev cuam tshuam zoo rau kev tswj cov roj metabolism.
Kev tiv thaiv kab mob:
Ursodiol ua ke nrog glucocorticoids tau pom tias muaj txiaj ntsig zoo hauv kev kho mob autoimmune kab mob siab. Nws tuaj yeem txhim kho daim siab lub peev xwm los ntawm kev hloov lub cev tiv thaiv kab mob, yog li inhibiting kab mob mus rau qee yam.
Anti-COVID-19 kab mob:
Cov kev tshawb fawb tshiab tshaj tawm qhia tias ursodeoxycholic acid tuaj yeem txo qhov kev pheej hmoo ntawm COVID-19 kab mob los ntawm kev tswj hwm FXR receptor function. Txoj kev tshawb no, luam tawm nyob rau hauv phau ntawv journal Nature, muab kev nkag siab tshiab rau hauv daim ntawv thov muaj peev xwm ntawm Ursodiol hauv kev tiv thaiv kab mob sib kis.
Lwm yam teebmeem:Ntxiv rau cov teebmeem saum toj no, Udca Powder kuj tseem muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob plawv, tiv thaiv kab mob thiab lwm yam teebmeem. Cov teebmeem no yuav yog qhov txuas ntxiv ntawm cov teebmeem saum toj no, qhia txog nws txoj kev tswj hwm kev noj qab haus huv ntau yam hauv.
Raws li Tuam Tshoj udca hmoov lwm tus neeg, peb tau cog lus los muab cov neeg siv khoom zoo APIs los txhawb kev txhim kho kev lag luam tshuaj thiab txhawb tib neeg kev noj qab haus huv. Yog tias koj xav tau cov ntaub ntawv zoo, thov hu rau peb!
Kev kho mob ntawm UDCA
1. Kab mob cholestatic
Cov neeg mob uas muaj tus kab mob biliary cholangitis (PBC) yuav tsum tau kho nrog qhov ncauj UDCA 13 ~ 15 mg·kg-1·d-1 raws li kev kho tshuaj thawj kab [3].
2. Cholelithiasis
Ntxiv nrog rau cov pob zeb-solving nyhuv ntawm chenodeoxycholic acid, UDCA kuj tuaj yeem cuam tshuam kev nqus cov roj cholesterol hauv cov hnyuv thiab txo qis cov roj cholesterol hauv cov kua tsib, thiab muaj kev cuam tshuam tsawg dua li chenodeoxycholic acid. Qhov koob tshuaj txhua hnub yog 8 ~ 10mg / kg, thiab chav kho mob yog 12 ~ 24 lub hlis. Tom qab ua tiav pob zeb tawg, kev kho mob txuas ntxiv rau 6 lub hlis.
3. Cov kua tsib reflux gastritis
Cov kua tsib reflux yog ib qho ua rau mob gastritis. Pyloric sphincter insufficiency ua rau cov kua tsib rov qab mus rau hauv lub plab, uas ua rau lub plab tsis muaj zog los yog ua rau lub plab mucosal barrier muaj nuj nqi, ua rau lub plab mucosa cuam tshuam los ntawm digestive kua txiv, uas ua rau inflammatory dab, yaig, los ntshav, epithelial metaplasia thiab lwm yam pathological hloov. Thaum cov xwm txheej tso cai, daim ntawv thov luv luv ntawm ursodeoxycholic acid npaj yuav tsim nyog. Kev siv: 250mg ib hnub ib zaug, ib hnub ib zaug, ua ntej mus pw, 10-14 hnub.
Kev tshawb fawb UDCA tam sim no
Lub siab fibrosis yog kev kho cov lus teb rau qhov diffuse ntau dhau deposition thiab txawv txav ntawm extracellular matrix (ie, collagen, glycoproteins, proteoglycans, thiab lwm yam) tom qab ntau yam kev raug mob rau lub siab. Nws yog ib qho tseem ceeb ntawm txoj kev loj hlob ntawm ntau yam kab mob siab rau cirrhosis. Cov lus teb mob ntev ntev yog qhov yuav tsum tau ua ua ntej rau kev tsim cov fibrosis thiab lub zog tsav rau nws txoj kev loj hlob. Inhibiting daim siab mob, tiv thaiv daim siab hlwb, thiab tiv thaiv oxidation yog ib qho tseem ceeb ntsuas los tiv thaiv daim siab fibrosis.
UCDA muaj cov tshuaj tiv thaiv kab mob, cov kua tsib tso tawm-txhawb thiab tiv thaiv apoptotic thiab yog cov tshuaj tseem ceeb rau kev kho mob ntawm PBC. Cov kev tshawb fawb tau pom tias UDCA muaj cov nyhuv anti-fibrotic nyob rau hauv cov kua tsib duct ligation (BDL) nas thiab tuaj yeem txhawb lub siab rov tsim dua tshiab thiab txo qhov kev loj hlob ntawm daim siab fibrosis los ntawm kev ua kom tus ID1-WNT2/HGF signaling pathway. Txawm li cas los xij, daim ntawv thov tus nqi ntawm UCDA hauv kev txhim kho daim siab cov ntaub so ntswg fibrosis tseem tsis paub meej. Xav tau kev tshawb nrhiav thiab pov thawj ntxiv.
RAQ:
Q: Lub hauv paus ntawm ursodeoxycholic acid yog dab tsi?
A: Ursodeoxycholic acid yog thawj zaug pom nyob rau hauv dais bile. Tab sis kev sau cov kua tsib los ntawm cov bears nyob yog siab phem heev thiab yuav tsis kav ntev. Tam sim no Kintai tuaj yeem ua ke Udca los ntawm cholic acid, chenodeoxycholic acid thiab hyodeoxycholic acid los ntawm cov tshuaj synthesis, thiab nws tseem tuaj yeem siv cov txheej txheem biosynthesis los ua ke API siv cov kab mob.
Q: Puas yog Udca suav nrog cov khoom siv kua qaub thiab ntau npaum li cas?
A: Yog, tab sis tsawg heev (coj Dexi nqaij qaib bile acid ua piv txwv, nws cov ntsiab lus yog li 1/10 ntawm chenodeoxycholic acid). Tsis tshua muaj, tab sis tsis tas yuav siv tsis tau. Raws li lub tswv yim ntawm kev kho nws ua tshuaj, yog tias koj noj ntau dhau, nws yuav phem. Tam sim no, ob peb tus neeg mob siab rau cov tshuaj pharmacological ntawm Udca hauv cov khoom siv kua qaub, thiab peb tseem xav tau kev tshawb fawb ntxiv.
Q: Lub luag haujlwm ntawm yog dab tsiUrsodiolhauv cov khoom hauv dej?
A: Tam sim no tsis muaj cov ntaub ntawv ntxaws ntxaws qhia txog lub luag haujlwm ntawm Ursodiol hauv cov khoom hauv dej. Nws tseem yog rau cov kws tshawb fawb los muab cov ntaub ntawv los ntawm kev tshawb fawb thiab kev sim.
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Cim npe nrov: Tuam Tshoj ursodeoxycholic acid manufacturers, lwm tus neeg, Hoobkas
