Lappaconitine Hydrobromide

Xi'an Kintai Biotech Inc yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm lappaconitine hydrobromide hauv Suav teb. Thov koj xav tias dawb rau cov lag luam wholesale zoo lappaconitine hydrobromide muag ntawm no los ntawm peb lub hoobkas. Rau nqe kev sab laj, tiv tauj peb.

KINTAIBIO^®'s Lappaconitine Hydrobromide hmoovyog diterpenoid alkaloid active ingredient ua tib zoo muab rho tawm thiab purified los ntawm lub hauv paus ntawm Aconitum sinomontanum Nakai, ib tsob nroj nyob rau hauv tsev neeg Ranunculaceae. Cov khoom yog dawb crystalline hmoov, tsw tsw thiab iab hauv saj. Raws li cov khoom siv tsis yog - cov khoom siv tshuaj tua kab mob, cov khoom no muaj txiaj ntsig zoo heev thiab muaj peev xwm siv dav dav. High-kev ua haujlwm ua kua chromatography (HPLC) tsom xam qhia ib tug purity ntawm tshaj98%thiab cov ntsiab lus impurity tsawg dua 1%. Peb muab cov kev xaiv ntim tau yooj yim kom tau raws li qhov xav tau ntawm txhua qib, los ntawm kev tshawb fawb hauv chav kuaj mus rau kev tsim khoom lag luam.

Peb lub tuam txhab boasts niaj hnub ntau lawm kab thiab ib chav kawm 100,000 cleanroom uas tau ntsibGMPcov qauv, nruab nrog ntau-kev ua haujlwm extraction, concentration, chromatography, crystallization, thiab ziab cov khoom, ua tiav kaw- voj tswj thoob plaws hauv tag nrho cov txheej txheem los ntawm raw khoom pretreatment kom tiav cov khoom refining. Peb tau tsim kom muaj kev tswj xyuas zoo, thiab peb cov khoom lag luam tau ua tiav dhau ntau qhov kev lees paub thoob ntiaj teb zoo thiab cov khoom pov thawj, suav nrogUS FDAsau npe,ISO9001, HACCP, thiabHalal. Txhua batch ntawm cov khoom tau dhau los ua cov kev kuaj physicochemical nruj thiab chromatographic tsom xam kom ntseeg tau tias muaj qib siab ntawm kev sib xws thiab kev ruaj ntseg hauv qhov zoo ntawm cov khoom siv, muab cov neeg siv khoom muaj kev nyab xeeb, txhim khu kev qha, thiab traceable siab - zooLappaconitine Hydrobromide hmoovcov khoom.

Ntxiv nrog rau nws cov txiaj ntsig zoo thiab muaj zog analgesic,Lappaconitine Hydrobromide hmoovkuj tseem muaj cov tshuaj loog tseem ceeb hauv zos, tshuaj tua kab mob, thiab tiv thaiv- cov khoom ua mob. Cov kev tshawb fawb tshuaj toxicological tau lees paub tias cov khoom no tsis yog-เสพ, kev tshawb fawb tsiaj tsis tau qhia txog cov teebmeem teratogenic, thiab siv sijhawm ntev - yuav tsis ua rau muaj kev lom lom ntau ntxiv. Raws li nws cov khoom siv tshuaj zoo tshaj plaws thiab kev nyab xeeb zoo, Lappaconitine Hydrobromide yog dav siv rau kev mob postoperative, mob cancer, rheumatism, sciatica, toothache, gastrointestinal ulcer mob, thiab ntau yam mob nruab nrab mus rau hnyav. Nyob rau hauv xyoo tas los no, nws cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv - mob, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob tshuaj tiv thaiv kab mob kuj tau txais kev saib xyuas ntxiv.

Raws li tus kws tshaj lij kev lag luam ntawm cov nroj tsuag extract hauv Suav teb,KINTAIBIO^®tau cog lus los tsav kev txhim kho kev lag luam los ntawm kev siv technology tshiab. Peb muaj ib qho kev ywj pheej R&D kuaj mob siab rau muab cov tuam txhab tshuaj thoob ntiaj teb nrog siab -purity, siab - zoo, thiab ruaj khov heevLappaconitine HydrobromideAPIs thiab tshuaj intermediates. Thov hu rau peb ntawmsales@kintaibio.com.

• Production Excellence:Lub zog hauv kev tsim khoom; Hoobkas ncaj qha lag luam wholesale nqi
• Quality Assurance:Kev xaiv cov khoom siv nruj; batch stability zoo ib yam
• Yam khoom muaj:Npaj cov khoom muag; siab purity specifications; Zoo solubility dej
• Kev Pab Txhawb Cov Neeg Siv Khoom:Kev txhawb nqa kev xeem; qauv muaj

• Kev txiav txim siab los ntawm titration thiab HPLC

KINTAIBIO^®xaiv Aconitum carmichaelii, tshuaj ntsuab txhua xyoo uas yog tsev neeg Ranunculaceae, ua nws cov khoom siv raw. Cov tsiaj no feem ntau yog faib rau sab qaum teb sab hnub poob thiab nruab nrab Suav teb, xws li Gansu, Qinghai, Shaanxi, thiab Sichuan xeev, thiab feem ntau loj hlob ntawm cov nyom nyom lossis hav zoov ntug. Los xyuas kom meej lub ntuj purity thiab qhabnias zoo ntawm lubLappaconitine Hydrobromidecov khoom los ntawm qhov chaw, peb cov ntaub ntawv raw yog los ntawm qhov siab - thaj chaw siab tshaj 2500 meters hauv Xinjiang.

Cov cheeb tsam no tsis muaj kuab lom-dawb, muaj qhov sib txawv ntawm qhov kub thiab txias, thiab cov av yog nplua nuj nyob rau hauv cov zaub mov, cia cov tsiaj qus Aconitum carmichaelii loj hlob qeeb nyob rau hauv tej yam ntuj tso tej yam kev mob, accumulating ib tug richer npaum li cas ntawm cov metabolites theem nrab. Ua tsaug rau qhov tshwj xeeb no thiab cov txheej txheem tshem tawm cov neeg paub tab, cov khoom tiav, raws li pom los ntawm siab -kev ua haujlwm ua kua chromatography, nthuav tawm cov ntsiab lus ruaj khov thiab tsawg tsawg batch-rau-batch variation, fundamentally guaranteeing the high activity and similarity of each batch.

Herbal Base ntawm Aconitum sinomontanum Nakai

Aconitum sinomontanum Nakai

Cov hauv paus hniav ntawm Aconitum sinomontanum Nakai

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Raws li kev sim tshuaj pharmacological tshiab,Lappaconitine hydrobromidemuaj cov teebmeem hauv qab no rau kev noj qab haus huv:

Lappaconitine Hydrobromide rau kev kho mob

Lappaconitine yog ib qho diterpenoid alkaloid nrog rau kev ua kom mob plab, thiabnws cov nyhuv analgesic yog ze ze rau cov kev cai ntawm qhov voltage-gated sodium ion channel Nav1.7. Tsis ntev los no kev txhim kho cov qauv kev tshawb fawb siv lappaconitine raws li niam txiv nucleus tau pom tias kev hloov kho ntawm 20-N txoj hauj lwm ua rau nws muaj peev xwm inhibitory ntawm tib neeg Nav1.7 channel. Tus neeg sawv cev derivative nthuav tawm 8.6-fold nce hauv kev ua haujlwm inhibitory tiv thaiv Nav1.7 piv rau lappaconitine, thiab ntxiv dag zog rau nws cov nyhuv inhibitory ntawm sodium tam sim no thiab kev ua haujlwm muaj peev xwm tua hauv dorsal cag ganglion (DRG) neurons.

Hauv tus qauv nas ntawm qhov mob tom qab phais, qhov kev sib piv no tau pom zoo tshaj qhov kev daws teeb meem ntawm mechanosensitive hyperalgesia piv rau lappaconitine, thaum nws qhov kev nyab xeeb kev nyab xeeb tau nce ntau dua 10 npaug. Qhov no qhia tau hais tias muaj peev xwm zoo rau kev tsim cov tshuaj tua kab mob tshiab raws li lappaconitine thiab ua pov thawj ntxiv rau qhov tseem ceeb ntawm kev tshawb fawb tus nqi thiab daim ntawv thov kev cia siab ntawm lappaconitine raws li lub ntuj diterpenoid alkaloid hauv kev tswj kev mob.

Lappaconitine Hydrobromide Los tiv thaiv- mob

Aconitum cag extractlappaconitine muaj tshuaj tiv thaiv - mob thiab mob ntev;Cov kev tshawb fawb metabolomics tsis ntev los no tau muabntau nyob rau hauv - qhov tob molecular - qib pov thawj rau cov inflammatory analgesic mechanismntawm apigenin hydrobromide. Cov kws tshawb fawb tau tshawb xyuas nws cov txiaj ntsig kev noj qab haus huv los ntawm kev kho cov nas nrog ntau koob tshuaj apigenin hydrobromide. Cov txiaj ntsig ntawm kev coj cwj pwm tau pom tias ob koob tshuaj apigenin hydrobromide ua rau txo qis paw tshem tawm latency (PWL) hauv cov nas, qhia tau hais tias muaj txiaj ntsig zoo. Cov seem histological tau lees paub ntxiv tias cov tshuaj txo qis qhov mob thiab o ntawm cov nas paws thiab pob taws, thiab tsis muaj qhov txawv txav tseem ceeb hauv cov ntaub so ntswg dorsal cag ganglion (DRG), qhia txog kev pom zoo thiab kev nyab xeeb.

Kev tsom xam metabolic qhia tau hais tias nyob rau hauv cov mob inflammatory xeev, retinol thiab glycerophospholipid metabolism hauv nas dorsal cag ganglion tau cuam tshuam loj heev, uas yuav ua rau mob hnyav thiab ua rau mob tsis tu ncua. Tom qab kev kho mob nrog apigenin hydrobromide, -linolenic acid metabolism raug kho, thaum retinol metabolism yog downregulated. Cov txiaj ntsig no qhia tau hais tias hydrobromide tuaj yeem txo qhov mob zoo, thiab nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam nrog nws cov kev tswj hwm ntawm lipid metabolism hauv cov hauv paus dorsal ganglion ntawm nas.

lappaconitine hydrobromide rau lub ntsws

Cov kev tshawb fawb tsis ntev los no tau qhia tiaslappaconitine hydrobromide muaj peev xwm tiv thaiv kev raug mob ntawm lub ntsws. Kev tshawb fawb tau pom tias LAH tuaj yeem ua tus tshiab NR1H3 agonist, txhim kho NR1H3 kev hloov pauv kev ua haujlwm thiab inhibiting TLR4 aggregation ntawm lipid rafts, yog li thaiv kev ua kom lub TLR4-NLRP3 signaling pathway thiab ntxiv txo NLRP3 inflammasome sib dhos thiab GSDroptosis.

Kev sim hauv vitro thiab hauv vivo tau pom tias LAH cuam tshuam qhov ua kom muaj mob ntawm qhov mob -cov cim qhia thiab txo cov kev mob tshwm sim thiab pyroptosis los ntawm kev tswj hwm NR1H3-NLRP3-GSDMD axis. Nws tau zoo txo ​​qhov mob ntsws ntsws puas tsuaj hauv lipopolysaccharide- thiab cecal fecal plasma-induced nas sepsis ntsig txog mob ntsws mob qauv. Kev txheeb xyuas cov ntaub ntawv pov thawj thiab bioinformatics ntxiv tau lees paub tias cov noob muaj feem cuam tshuam rau kev tsim cov interleukin-1, kev tswj hwm kev mob tshwm sim, thiab kev tiv thaiv kab mob hauv lub cev tau hloov pauv tseem ceeb tom qab kho LAH, qhia tias lappaconitine hydrobromide muaj peev xwm tshawb fawb muaj txiaj ntsig hauv kev tswj lub ntsws o thiab tswj lub ntsws homeostasis.

Tsis tas li ntawd, Lappaconitine Hydrobromide kuj muaj cov txiaj ntsig hauv qab no:

• Cov nyhuv anti-arrhythmictuaj yeem txhim kho myocardial ischemic arrhythmia, yog li txo qhov tshwm sim ntawm arrhythmia;
• Txias thiab tshem tawm ua npaws: Nws muaj cov nyhuv antipyretic tseem ceeb ntawm ntau hom kub taub hau thiab nws cov nyhuv txias yog sib npaug rau cov tshuaj aspirin thiab lwm yam tshuaj Western.

Tau qhov twg los: https://www.sciencedirect.com/science/article/abs/pii/S0223523426001996

https://www.mdpi.com/2218-1989/12/10/923

https://www.sciencedirect.com/science/article/pii/S2095177926000869

Lappaconitine thiab nws daim ntawv ntsev,lappaconitine hydrobromide, muaj kev thov dav dav hauv thaj chaw kho mob thiab tshuaj txhim kho.

Tom qab siv sijhawm ntev - kev soj ntsuam daim ntawv thov raug lees paub, lappaconitine hydrobromide tau dhau los ua kev nyab xeeb thiab siv tau zoo uas tsis yog- tshuaj tua kab mob, feem ntau yog siv los txo cov mob qog noj ntshav, mob tom qab phais, mob hniav, dysmenorrhea, thiab lwm yam mob hnyav. Nws tuaj yeem npaj tau ntau hom tshuaj xws li ntsiav tshuaj, txhaj tshuaj, hmoov, thiab thaj ua rau thaj. Ntxiv rau nws cov nyhuv analgesic, nws kuj muaj qee yam tshuaj tiv thaiv - mob thiab tiv thaiv - o los.

Hauv cov hlab plawv, lappaconitine hydrobromide kuj tseem siv tau rau hauv kev tshawb fawb thiab kev kho mob ntawm arrhythmias, thiab tuaj yeem siv los kho cov kab mob xws li kev mob plawv ntxov ntxov, atrial fibrillation, supraventricular tachycardia, thiab ventricular tachycardia.

Tsis tas li ntawd, raws li cov khoom muaj txiaj ntsig tau los ntawm cov nroj tsuag ntuj, lappaconitine thiab nws cov derivatives tau txais kev saib xyuas tas li nyob rau xyoo tas los no hauv kev tswj mob, kev tswj kev mob, thiab kev txhim kho cov tshuaj tshiab, ua kom pom cov txiaj ntsig zoo thiab kev loj hlob muaj peev xwm.

Hauv Russia thiab lwm lub tebchaws,lappaconitine hydrobromidekuj yog siv los ua ib qho chaw kho mob thawj zaug - kab tshuaj rau kev kho mob ntawm arrhythmias xws li ventricular premature beats, atrial fibrillation, supraventricular thiab ventricular tachycardia. Nws cov kev npaj tau dhau los ua ib qho tshiab uas tsis yog - tshuaj tua kab mob ntxiv rau nws tus kheej tsim los ntawm Tuam Tshoj, thiab yog cov tshuaj tua kab mob nruab nrab uas tau teev tseg hauv "Cov Lus Qhia rau Peb-Txoj Kev Kho Mob Rau Cov Neeg Mob Cancer" ntawm Ministry of Health ntawm Tuam Tshoj.

• Houginine hydrobromide ntsiav tshuaj: 5 mg; 10 mg.
• Hovenine hydrobromide rau kev txhaj tshuaj: 4 mg; 8mg ib.
• tso zis hydrobromide: 4mg / 2ml; 8 mg/2 ml.
• Urumine hydrobromide glucose txhaj: 250 ml (4 mg tso zis hydrobromide, 12.5 grams ntawm 5) qabzib); 500 ml (8 mg urine hydrobromide, 25 grams qabzib)

Lapaconitine Hydrobromide Kev Nyab Xeeb

Lappaconitinethiab nws cov ntsev npaj muaj keeb kwm ntev ntawm kev tshawb fawb thiab kev kho mob daim ntawv thov nyob rau hauv lub tshav pob ntawm analgesia, thiab feem ntau muaj ib tug zoo kev ruaj ntseg profile thaum siv nyob rau hauv cov txheej txheem.

Lappaconitine Hydrobromide Dosage

Cov koob tshuaj tshwj xeeb yuav tsum tau txiav txim siab los ntawm tus kws kho mob kws kho mob raws li daim ntawv ntau npaum, txoj kev tswj hwm, kev qhia, thiab tus neeg mob tus mob. Tus kheej- tsis pom zoo hloov cov koob tshuaj.

Lappaconitine Hydrobromide Sab Nraud

Cov kev tshawb fawb thiab cov ntaub ntawv kho mob uas twb muaj lawm qhia tau tias muaj kev cuam tshuam tsis zoo rauLapaconitine Hydrobromide-Txoj kev npaj muaj feem ntau yog me me thiab thim rov qab. Feem ntau tshwm sim muaj xws li xeev siab, ntuav, tsis xis nyob hauv plab, kiv taub hau, mob taub hau, ua pob, khaus, thiab ntuav palpitations lossis tachycardia. Feem ntau cov tsos mob tuaj yeem kho tau tom qab txiav cov tshuaj lossis hloov cov tshuaj.

Muaj tsawg zaus, tshwj xeeb tshaj yog nrog cov koob tshuaj ntau lossis txhaj tshuaj, kev tsis haum tshuaj, arrhythmias, lossis lwm yam kab mob plawv tuaj yeem tshwm sim. Yog li ntawd, cov hlab plawv thiab paj hlwb yuav tsum tau saib xyuas thaum siv.

Cov tshuaj sib cuam tshuam nrog Lapaconitine Hydrobromide

Lapaconitine Hydrobromideyuav tsum zam rau cov tib neeg uas paub tias muaj kev ntxhov siab rau lappaconitine lossis nws cov khoom muaj feem xyuam. Tsis tas li ntawd, nws siv ua ke nrog cov tshuaj uas yuav cuam tshuam rau kev mob plawv lossis lub paj hlwb hauv nruab nrab yuav tsum tau ua raws li kev qhia ntawm tus kws kho mob uas tsim nyog.

Feem ntau, kev nyab xeeb ntawm cov khoom lappaconitine yuav tsum raug soj ntsuam tag nrho los ntawm kev txiav txim siab txog kev tsim tshwj xeeb, kev siv tshuaj, thiab kev sib txawv ntawm tus kheej, thiab yuav tsum tau siv raws li cov cai thiab cov txheej txheem kho mob kom ntseeg tau tias nws cov txiaj ntsig thiab kev nyab xeeb.

Raws li qhov chaw tsim khoom ntawmLappaconitine Hydrobromide hmoov, KINTAIBIO^®'s muaj cov khoom zoo hauv qab no:

vim li cas thiaj xaiv peb cov khoom?

 

• Cov txheej txheem zoo extraction:Peb siv cov thev naus laus zis thev naus laus zis thev naus laus zis thev naus laus zis, ua ke nrog cov txheej txheem alkalization thiab cov txheej txheem tshem tawm cov kuab tshuaj, kom tau txais txiaj ntsig zoo los ntawm Aconitum hauv paus, txhim kho kev ua haujlwm zoo.

 

• Fine purification txheej txheem:Los ntawm hydrochloric acid acidification thiab anhydrous sodium carbonate alkalization txheej txheem, impurities tuaj yeem raug tshem tawm kom tau txais siab -purity aconitine crude alkali, ua kom cov khoom zoo thiab purity ntawm cov khoom.

 

• Kev tshem tawm impurity technology:Kev siv cov chromatographic alumina filtration rau adsorb impurities tuaj yeem ua kom huv si ntxiv, txo cov ntsiab lus impurity, thiab txhim kho purity thiab zoo ntawm cov khoom.

 

• Crystallization refining txheej txheem:Siv cov khoom siv hluav taws xob zoo li qub thiab lub tshuab nqus kom qhuav, cov khoom siv lead ua tuaj yeem ua kom tiav thiab ntxuav kom zoo kom tau txais cov khoom siv zoo -cov khoom siv ntxhib zoo, uas muab cov khoom siv raw zoo rau kev ua haujlwm zoo thiab cov tshuaj tiv thaiv.

 

• Environmentally tus phooj ywg thiab muaj txiaj ntsig:Peb cov txheej txheem tshiab tsis yog tsuas yog txhim kho kev tsim khoom thiab cov khoom lag luam zoo, tab sis kuj tseem them nyiaj rau kev tiv thaiv ib puag ncig, txo cov emissions ntawm pov tseg thiab cov pa phem, thiab yog nyob rau hauv txoj kab nrog lub tswv yim tshiab ntsuab ntau lawm.

Cov txheej txheem saum toj no ua rau peb tsim cov khoom siab - zoo, siab - purityLappaconitine Hydrobromide hmoov, uas ua tau raws li peb cov neeg siv khoom xav tau rau cov khoom lag luam zoo thiab purity, thaum tseem txhim kho peb cov kev tsim khoom thiab txo cov nqi tsim khoom.

Yog tias koj xav yuav siab - zoo Aconitum cag extract Lappaconitine hydrobromide, thov koj xav tiv tauj peb ntawmsales@kintaibio.comlos yog tawm tswv yim nyob rau nplooj ntawv tom ntej.

Cim npe nrov: Tuam Tshoj lappaconitine hydrobromide manufacturers, lwm tus neeg, Hoobkas