Txo Glutathione Hmoov

Txo Glutathione Hmoov(Glutathione, GSH) yog ib qho me me molecule tripeptide muaj li ntawm glutamic acid, cysteine, thiab glycine. Tib neeg tuaj yeem tsim cov glutathione hauv cov hlwb. Nws yog dav faib nyob rau hauv ntau yam hauv nruab nrog cev ntawm lub cev thiab plays lub luag hauj lwm tseem ceeb nyob rau hauv kev tswj cov roj ntsha functions ntawm hlwb.

Nws yog ib pawg prosthetic ntawm glyceraldehyde phosphate dehydrogenase thiab coenzyme ntawm glyoxalase thiab triose dehydrogenase. Nws koom nrog hauv lub voj voog tricarboxylic acid thiab qabzib metabolism hauv lub cev, thiab tuaj yeem qhib ntau yam enzymes, yog li txhawb cov piam thaj, rog, thiab Protein metabolism tuaj yeem cuam tshuam cov txheej txheem metabolic ntawm cov hlwb. Nws tuaj yeem ua ke nrog cov dawb radicals hauv lub cev los ntawm cov pab pawg sulfhydryl los hloov lawv mus rau hauv cov kua qaub yooj yim metabolized kom nrawm cov tawm ntawm cov dawb radicals.

Yuav luag txhua lub cell hauv tib neeg lub cev muaj GSH. Nws qhov kev faib tawm hauv lub cev yog qhov thib ob tsuas yog cov dej molecules. GSH yog thiol nrog cov ntsiab lus siab tshaj plaws hauv cov tsiaj hlwb. Feem ntau, cov concentration hauv hlwb yog nyob nruab nrab ntawm 0.5 mus rau 2 mM. Raws li qhov loj tshaj plaws detoxification lub cev nyob rau hauv tib neeg lub cev, cov ntsiab lus GSH yog siab li 10 mM. Extracellular GSH concentrations sib txawv hauv zos, thiab plasma GSH yog nyob rau hauv micromolar ntau.

Glutathione kuj ua lub luag haujlwm tseem ceeb hauv lwm yam tsiaj thiab nroj tsuag. Cov ntsiab lus nyob rau hauv baker cov poov xab, hom qoob mog, thiab tsiaj lub siab yog 100 ~ 1000 mg / 100g, nqaij qaib cov ntshav muaj 58 ~ 73 mg / 100g, thiab cov ntshav npua muaj 10 ~ 15 mg / 100g.

Glutathione muaj peb lub luag haujlwm tseem ceeb los tiv thaiv oxidation, detoxification, thiab kev tiv thaiv kab mob.

(1) Antioxidant
Kev sib sau ntawm ntau cov pa oxygen dawb radicals thiab peroxides hauv tib neeg lub cev yuav ua rau oxidation ntawm cov proteins, lipids, thiab DNA, thiab oxidative kev nyuaj siab feem ntau cuam tshuam nrog cov kab mob xws li mob caj dab, pulmonary fibrosis, Parkinson's, ntau yam sclerosis, cancer, thiab kev laus. Yog li ntawd, nws yog ib qho tsim nyog yuav tau noj cov tshuaj antioxidants txaus los tawm tsam cov kev puas tsuaj los ntawm cov dawb radicals.

Glutathione yog cov khoom siv dav tshaj plaws thiab cov ntsiab lus siab tshaj plawsantioxidant nyob rau hauv tib neeg lub hlwb. Glutathione tuaj yeem tshem tawm cov peroxides hauv cov cell thiab cov pa dawb radicals, tiv thaiv cell membrane lipids, DNA, thiab sulfhydryl enzymes los ntawm oxidation, thiab xyuas kom meej qhov kev ua tau zoo ntawm molecular physiological functions. Qhov kev ua haujlwm no tsuas yog ua tiav los ntawm kev ua haujlwm ntawm pawg sulfhydryl hauv cysteine.

2 GSH + R2O2 → GSSG plus 2 ROH (R=H, alkyl)

GSH plus R. → 0.5 GSSG plus RH

GSH kuj tau koom nrog ntau yam kev cuam tshuam redox hauv cov hlwb, tshem tawm cov kev puas tsuaj ntawm oxidants rau cov txheej txheem membrane ntawm cov qe ntshav liab, thiab tswj kev ruaj ntseg ntawm cov qauv membrane ntawm cov qe ntshav liab.

(2) Detoxification
Cov pab pawg mercapto ntawm GSH tuaj yeem chelate cov co toxins xws li cov hlau hnyav, fluoride, thiab mustard gas, thiab feem ntau yog siv los ua ke nrog tshuaj lom lossis tshuaj tua kab mob thiab cov kev mob tshwm sim. Yog li ntawd, cov ntsiab lus ntawm GSH nyob rau hauv daim siab hlwb yog ntau dua li nyob rau hauv lwm lub hlwb.

Qhov tsis muaj GSH yuav ua rau apoptosis ntawm daim siab hlwb, ua rau lub siab rog. GSH supplementation tuaj yeem ua rau cov ntshav protein ntau, enzyme, thiab bilirubin qib hauv cov neeg mob uas muaj lub siab rog ntev, thiab GSH tso rau hauv cov hlab ntsha tuaj yeem txo cov qib ntawm malondialdehyde, qhov cim ntawm daim siab puas.

(3) Txhim khu kev tiv thaiv
GSH tsis tsuas yog tiv thaiv lub cev tiv thaiv kab mob los ntawm kev puas tsuaj, tab sis kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tswj hwm qhov sib npaug ntawm lub cev tiv thaiv kab mob, thiab nws qhov kev xav ncaj qha yog kev tiv thaiv ntawm lub cev tiv thaiv kab mob telomeres.

Cov nyhuv ntawm GSH ntawm lub cev tiv thaiv kab mob kuj tshwm sim hauv kev ua haujlwm ntawm kev txhawb nqa T cell ua kom muaj zog, kev loj hlob, thiab kev sib txawv, thiab ua lub luag haujlwm tseem ceeb hauv kev tswj T cell tiv thaiv.

GSH kuj tseem muaj kev tiv thaiv kab mob ncaj qha. GSH-enhanced adjuvant therapy rau COVID-19 cov neeg mob tuaj yeem txhim kho tus neeg mob lub cev tiv thaiv kab mob thiab txo qhov kev pheej hmoo ntawm tus kab mob hnyav.

Ntxiv rau peb lub ntsiab lus saum toj no, GSH kuj tseem koom nrog hauv cov txheej txheem xws li kev tswj hwm cov metabolism, kev hloov pauv paj hlwb, kev loj hlob ntawm tes, thiab apoptosis, yog li nws tuaj yeem hais tias yog txhua qhov kev sib tw. GSH tuaj yeem txo kev mob caj dab thiab txo qhov mob, thiab cov nyhuv whitening coj los ntawm nws cov antioxidant thiab detoxification muaj peev xwm tau ntev tau nthuav dav.

Kev laus, mob qog noj ntshav, cystic fibrosis, hlab plawv, o, kev tiv thaiv kab mob tsis txaus, kab mob neurodegenerative, thiab lwm yam yuav dhau-deplete lub cev ntawm GSH. Kev noj zaub mov tsis zoo, kab mob ntev, kev kis kab mob, thiab kev ntxhov siab tas li tuaj yeem ua rau kom tsis muaj glutathione. Qhov tsis muaj GSH yuav ua rau muaj cov dawb radicals, co toxins, thiab lwm yam, ua rau nws muaj kev cuam tshuam rau cov kab mob thiab kab mob, cov tshuaj tiv thaiv kab mob, thiab kev laus ntxov ntxov, thiab lwm yam, poob rau hauv lub voj voog vicious.

Tib neeg GSH poob qis dua 70 feem pua ​​​​ntawm cov qib ib txwm muaj, thiab nws yuav nyuaj rau kev tswj hwm lub cev zoo li qub.

Txhawm rau tswj hwm qib GSH ruaj khov hauv lub cev, tib txoj hauv kev yog "qhib qhov chaw" thiab "txhim kho kev siv nyiaj".

"Throttling" yog hais txog kev tswj kom noj qab haus huv tus cwj pwm, txo cov tiam ntawm cov dawb radicals, thiab txo cov co toxins nyob rau hauv ib puag ncig, xws li cawv, khoom qab zib, nitrite, hluav taws xob hluav taws xob, huab cua paug, thiab lwm yam, yog li txo qis GSH noj ntau dhau.

"Qhib qhov chaw" yog muab cov peev txheej tiv thaiv oxidation thiab detoxification txaus rau tib neeg lub cev los ntawm kev ntxiv GSH los txhim kho lub cev tiv thaiv kab mob. Hais txog kev noj zaub mov, ntxiv rau kev noj zaub mov uas muaj GSH, koj tuaj yeem noj ntau cov zaub mov uas muaj leej faj, vitamins C, D, E, thiab selenium.

Txawm li cas los xij, qhov teeb meem loj tshaj plaws nrog glutathione tam sim no yog nws qhov ncauj tsis tshua muaj bioavailability, thiab nws feem ntau yog hydrolyzed nyob rau hauv lub plab zom mov thiab tsis tuaj yeem nkag mus rau cov hlwb los ua lub luag haujlwm. Yog li ntawd, GSH tau noj los ntawm cov zaub mov yog qhov nyuaj rau kev nqus thiab siv, thiab cov khoom noj ntxiv yuav tsum tau ua kom tau txais kev txhim kho thaum nws tsis muaj. Thaum xaiv cov tshuaj ntxiv, kev saib xyuas yuav tsum tau them rau daim ntawv ntau npaum. Feem ntau, cov cuab yeej siv tshuaj xws li liposomes thiab microphospholipid bilayer encapsulation tuaj yeem xa cov tshuaj zoo dua rau lub hom phiaj, txhawm rau ua kom lawv cov txiaj ntsig zoo.

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