Xi'an Kintai Biotech Inc yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm Citicoline CDP Choline Powder hauv Suav teb. Thov koj xav tias dawb rau cov lag luam wholesale siab zoo Citicoline CDP Choline hmoov rau muag ntawm no los ntawm peb lub hoobkas. Rau nqe kev sab laj, tiv tauj peb.
Citicoline CDP Choline Powder Chaw tsim tshuaj paus
Raws li cov chaw tsim khoom lag luam mob siab rau R&D thiab tsim cov khoom zoo ntawm - zoo cog extract hmoov,KINTAIBIO®'s Citicoline (CDP-Choline) hmoovqhia tau tias muaj nuj nqis tseem ceeb hauv kev noj qab haus huv ntawm lub hlwb. Citicoline-tseem hu uacytidine diphosphate -cholinelos yogCDP{0}}choline- yog ib qho endogenous mononucleotide ib txwm muaj nyob hauv cov hlwb ntawm tib neeg thiab tsiaj cov ntaub so ntswg, muaj li ntawm ribose, cytosine, pyrophosphate, thiab choline.Lub mechanism ntawm kev txiav txim ntawm citicolineyog pom zoo los ntawm kev tshawb fawb dav dav pom tias nws txhim kho kev ua haujlwm ntawm lub paj hlwb ascending reticular activating system, txhim kho pyramidal system muaj nuj nqi, thiab txhawb cerebral metabolism los ntawm kev txo cerebrovascular tsis kam thiab nce cerebral ntshav txaus.
Peb Citicoline raw cov ntaub ntawv yog muab nyob rau hauv hmoov daim ntawv, nrog specifications nruj me ntsis adhering rau lub monographs ntawm lubUSP43/NF38tshuaj kho mob. Txheeb xyuas los ntawm kev ywj pheej thib peb -kev sim thib peb, qhov purity tsis tu ncua ntau dua98% , xyuas kom cov uniformity thiab stability ntawm txhua ntau lawm batch. Peb siv cov txheej txheem biosynthetic siab heev los ua kom muaj siab -purityCiticoline (CDP-Choline) hmoov, precisely mimicking cov qauv molecular ntawm endogenous compound kom lav superior bioavailability thiab kev nyab xeeb.
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Hauv kev siv tswv yim, cov khoom no ua haujlwm tseem ceeb hauv cov khoom noj khoom haus; Nws yog siv dav hauv cov qauv tsim los txhawb kev kho mob hlwb hauv nruab nrab- cov neeg laus thiab cov neeg laus, txhim kho kev txawj ntse hauv cov tub ntxhais kawm thiab cov kws tshaj lij ua haujlwm, thiab pab txhawb kev noj zaub mov zoo rau kev rov qab los tom qab raug mob neurological.
Yuav Ua Li Cas Citicoline CDP Choline hmoov?
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Txoj kev ua kom muaj zog thiab kev npaj noob kab lis kev cai
Bacillus subtilis yog inoculated rau hauv kab lis kev cai nruab nrab uas muaj 0.1-5% qabzib, 0.5-5% nqaij nyuj extract, 1-10% peptone, 0.5-5% poov xab extract, thiab 0.5-1% sodium chloride. Cov kab lis kev cai yog incubated ntawm qhov kub tsis tu ncua ntawm 32℃kom txog thaum cov piam thaj depleted, yog li yielding lub activated hom. Tom qab ntawd, cov kab lis kev cai no tau hloov mus rau hauv cov noob kab lis kev cai nruab nrab ntawm qhov sib piv ntawm 5 wt%. Cov noob kab lis kev cai nruab nrab muaj cov tshuaj aqueous uas muaj cov pa roj carbon, cov khoom siv nitrogen, thiab cov kab mob, ntxiv nrog 0.1-3% phosphate. Cov sib tov yog cog nyob rau hauv co los yog aeration tej yam kev mob ntawm 30-35℃rau 5-25 teev kom tau ib tug kab lis kev cai broth uas muaj ib tug siab ceev ntawm microorganisms A, uas yog ces siv rau cov tom ntej biotransformation txheej txheem.
Enzymatic Biotransformation rau Cytidine 5'-diphosphocholine (CDP-}choline) Synthesis
Choline feedstock yog ntxiv rau cov kab lis kev cai hais saum toj no uas muaj cov kab mob A ntawm qhov concentration ntawm 0.5-3 wt% piv rau tag nrho qhov hnyav ntawm kab lis kev cai broth. Optionally, 0.005–0.05 wt% ntawm cov surfactant Tween-80 yuav raug ntxiv los pab txhawb kev sib cuag ntawm cov substrate thiab cov microbial hlwb. Cov tshuaj tiv thaiv kub yog khaws cia ntawm 20℃thiab 38℃rau lub sijhawm ntawm 10-72 teev, thaum acid-base regulators yog ua hauj lwm los tswj cov pH nyob rau hauv thaj tsam ntawm 6 txog 7. Nyob rau hauv cov xwm txheej no, cov kab mob siv lawv cov intrinsic de novo pyrimidine biosynthesis txoj hauv kev los tsim thiab tsim.CDP{0}}choline, siv choline ua tus thawj coj. Thaum ua tiav cov tshuaj tiv thaiv, qhov concentration ntawm CDP-choline nyob rau hauv fermentation broth nce mus txog qib siab; Kev nce qib ntawm cov tshuaj tiv thaiv yog saib xyuas siv High-Performance Liquid Chromatography (HPLC).
Extraction thiab Purification ntawm CDP-choline
Tom qab ua tiav ntawm fermentation, lub microbial hlwb thiab cellular khib nyiab yog thawj zaug muab tshem tawm ntawm tubular centrifugation los yog microfiltration los sau cov clarified fermentation supernatant. Tom qab ntawd tus supernatant tau dhau los ntawm cation - pauv resin kem rau adsorb CDP-choline. Tom qab ntawd cov impurities raug ntxuav tam sim ntawd siv cov dej deionized, ua raws li gradient elution siv cov tshuaj ammonia dilute los yog sodium chloride tov los sau cov eluate uas muaj CDP-choline. Lub resulting eluate undergoes decolorization kev kho mob siv activated carbon, ua raws li los ntawm concentration nyob rau hauv lub siab txo kom tshem tawm cov dej, yog li yielding ib tug concentrated khoom tov. Anhydrous ethanol los yog acetone yog ntxiv rau cov concentrate kom induce crystallization, thiab cov sib tov raug tso cai sawv ntsug rau precipitate dawb crystals. Tom qab centrifugation, cov muaju yog ntxuav nrog me me ntawm ethanol thiab thaum kawg nqus tsev vacuum- qhuav ntawm 40-50℃kom qhov hnyav tas li; Tom qab ntawd lub resulting khoom yog pulverized thiab sieved rau yieldCiticoline CDP-Choline hmoov.
Citicoline CDP Choline hmoov zoo rau dab tsi?
Citicoline CDP Choline hmoov rau kev nyuaj siab
Kev tshawb nrhiav preclinicalsiv tus txiv neej nas qauv ntawm mob neuropathic -induced ntawm sciatic paj ligation- soj ntsuam cov tshuaj anxiolytic thiab tshuaj tiv thaiv kev nyuaj siab -zoo li cov teebmeem ntawm citicoline. Cov txiaj ntsig tau lees paub tias kev tswj hwm intraperitoneal ntawmciticoline, ntawm ob qho tib si nruab nrab (50 mg / kg) thiab siab (100 mg / kg) koob tshuaj, ua rau muaj kev ntxhov siab ntau heev - thiab kev nyuaj siab- zoo li kev coj cwj pwm raug mob los ntawm paj hlwb. Kev tshawb nrhiav ntxiv tau qhia tias txawm tias qhov koob tshuaj tsawg (25 mg / kg) ntawm citicoline, thaum co- noj nrog ntau qhov sib txawv ntawm cov tshuaj tricyclic antidepressant imipramine, ua rau muaj txiaj ntsig zoo rau kev ntxhov siab thiab tshuaj tiv thaiv kev nyuaj siab -zoo li cov teebmeem ntawm imipramine.
Isobolographic tsom xam tau qhia tias citicoline thiab imipramine muaj cov txiaj ntsig sib txawv hauv kev hloov pauv ntawm kev ntxhov siab thiab kev nyuaj siab. Txoj kev tshawb no xaus li ntawdCiticoline CDP-choline hmoov, raws li kev noj haus ntxiv, tsis yog tsuas yog siv tau los txo kev ntxhov siab - thiab kev nyuaj siab- zoo li kev coj cwj pwm thaum siv ib leeg, tab sis kuj tseem txhim kho kev kho mob ntawm imipramine thaum siv ua ke. Cov pov thawj preclinical no muab lub hauv paus ruaj khov rau kev sivCiticoline CDP-choline hmoovhauv kev txhawb nqa kev xav txog kev xav.
Citicoline CDP Choline hmoov rau lub hlwb
Citicoline (CDP{0}}choline) hmoovtuav tus nqi tseem ceebnyob rau hauv kev hais txog cov hyper- cov xeev inflammatory tshwm sim los ntawm COVID-19 kis thoob qhov txhia chaw-nrog rau lawv cov kev puas tsuaj rau cov hlab ntsha neurovascular-thiab hauv kev tswj cov kev paub tsis meej thiab lwm yam teeb meem hauv paj hlwb uas tshwm sim tom qab kis kab mob. Cov qauv tshuaj lom neeg ntawm citicoline zoo ib yam li cov metabolite phosphatidylcholine's precursor; yog li ntawd, nws muaj txiaj ntsig zoo tswj cov txheej txheem kev ncaj ncees ntawm phospholipids hauv hlwb hlwb thiab ua kom lawv cov haujlwm ua haujlwm zoo.
Kev tshuaj xyuas dav dav tau piav qhia cov txheej txheem muaj peev xwm ntawm kev ua haujlwm uas citicoline ua haujlwm raws li kev kho mob thiab kev tiv thaiv tus neeg sawv cev. Los ntawm kev tsim txiaj ntawm nws cov khoom siv tshuaj kho mob ntau yam-xws li tshuaj tiv thaiv- mob, tshuaj tiv thaiv kab mob, neuroprotective, thiab neurorestorative cuam tshuam, nrog rau nws lub peev xwm los txhawb kev sib txuas ntawm neurotransmitter acetylcholine-citicoline qhia tau cog lus hauv qhov zoo ameliorating qhov kev nkag siab tsis zoo cuam tshuam nrog kev tsis sib haum xeeb com-1s.
Citicoline CDP Choline hmoov rau tsom
Kev ua tau zoo ntawmCiticoline CDP-choline hmoov hauv kev txhim kho tib neeg psychomotor ceeb toom thiab ua kom pom tseeb tau raug lees paub los ntawm randomized, placebo- tswj kev sim tshuaj. Cov txiaj ntsig ntawm kev tshawb fawb pom tau tias tom qab ob - kev cuam tshuam lub lim tiam, pawg placebo tsis muaj kev hloov pauv tseem ceeb hauv kev ceeb toom lossis pom kev ua haujlwm nco (P> 0.05); hloov pauv, pawg Citicoline tau ua tiav qhov kev txhim kho tseem ceeb thoob plaws feem ntau ntawm cov kev ntsuas ntsig txog kev ua haujlwm ntawm psychomotor thiab kev ua haujlwm nco (P <0.01).
Citicoline muaj peev xwm thim rov qab txoj kev nce siab ntawm oxidative kev ntxhov siab vim yog siab - siv lub siab xav ua haujlwm, qhia tias nws tsis tsuas yog txhawb kev paub txog kev ua tau zoo tab sis tseem tiv thaiv kev ncaj ncees ntawm lub paj hlwb ntawm qib cellular. Yog li ntawd, raws li ib tug nootropic nucleotide,Citicoline hmoovtxhim kho psychomotor ceeb toom, lub xeev ntawm arousal, thiab pom kev ua hauj lwm nco nyob rau hauv cov tib neeg noj qab nyob zoo, thaum zoo mitigating oxidative kev nyuaj siab puas los ntawm siab -xav tau kev txawj ntse kev ua ub no- yog li muab ib tug scientific hauv paus rau kev txhim kho kev tsom xam txhua hnub thiab kev txawj ntse endurance.
Siv:https://www.sciencedirect.com/science/article/pii/S2667242124000939
Citicoline CDP Choline hmoov siv rau dab tsi?
Citicoline CDP Choline hmoov ntxiv
Hauv kev tsim cov khoom noj khoom haus,Citicoline CDP-Choline hmoovmuaj peev xwm ua tau ntau yam, tso cai rau nws los tsim ua ntau hom ntawv ntau npaum li cas -nrog rau tus qauvciticolinethiabCDP-cov tshuaj choline. Tshwj xeeb, nws tuaj yeem tsim tau raws licdp choline ntsiav tshuaj, ntsiav tshuaj, thiab lwm yam qauv tsim nyog rau kev saib xyuas txhua hnub.CDP-choline sodiumtau txais txiaj ntsig zoo rau nws lub peev xwm kev txawj ntse - txhim kho cov khoom thiab nws cov txiaj ntsig rau tag nrho lub hlwb kev noj qab haus huv. Cov tshuaj no nquag txhawb nqa los ntawm kev pab txhim kho kev nco, ua kom pom tseeb, mloog zoo, thiab kev paub txog kev ua haujlwm.
Citicoline CDP Choline hmoov zog haus
Citicoline (CDP-Choline) hmoov kuj tseem tuaj yeem muab tso rau hauv cov dej haus kom tsim tauciticoline zog haus, yog li ua tau raws li cov kev xav tau tam sim ntawm cov tub ntxhais kawm thiab cov kws tshaj lij ua haujlwm rau kev ua kom pom tseeb thiab pom tseeb ntawm lub hlwb. Ib txoj kev tshawb fawb soj ntsuam tau lees paub tias kev ntxiv nrog 500 mg ntawm citicoline txhua hnub rau ob lub lis piam sib law liag tuaj yeem txhim kho psychomotor vigilance thiab pom kev ua haujlwm nco.
Citicoline CDP Choline hmoov qhov muag tee
Tsis tas li ntawd, muab nws lub luag haujlwm tshwj xeeb hauv kev kho cell membrane thiab neurotransmission,Citicolinekuj qhia tau hais tias muaj peev xwm rau kev siv nyob rau hauv lub teb ntawm ophthalmology, qhov twg nws muaj peev xwm yuav formulated rau hauvqhov muag pooblos pab txhawb optic paj hlwb noj qab haus huv. Hauv cov ntsiab lus, txawm tias lub hom phiaj yog txhawm rau txhim kho kev nco, kev xav, thiab tag nrho kev paub txog kev ua haujlwm, lossis ua kom lub hlwb noj qab haus huv hauv nruab nrab - cov neeg laus thiab cov neeg laus,Citicoline CDP-Choline hmoovtsim los ntawmKINTAIBIO®muaj kev tshawb fawb lub suab thiab ntau yam raw khoom tov.
Formula Development Support Services:
- Formulation Compatibility Research:Muab kev solubility (Ntau dua lossis sib npaug li 50mg / mL), kev ruaj ntseg kev sib raug zoo (cov ntaub ntawv ntsuas nrawm), thiab lwm cov ntaub ntawv tshawb fawb ua ntej.
- Instant Solubility Technology:Microencapsulation thev naus laus zis txo cov sij hawm tawg mus rau<15 seconds (USP<701>txheem).
- Taste Masking Solutions:-Cyclodextrin encapsulation txo qhov kev nkag siab ntawm iab iab los ntawm 72% (kev ntsuas ntsuas ntsuas ntsuas ISO 13299).
- Cov ntaub ntawv ruaj ntseg: 36-month accelerated testing at 40°C/75% RH shows content retention >97%.
- Compound Formula Database:suav nrog 32 cov khoom xyaw uas muaj kev sib koom ua ke (xws li DHA, PS).
Common Bulk Citicoline Powder formula:
- Citicoline + alpha-GPC: Alpha-GPC yog ib qho khoom siv ntuj tsim uas ntseeg tau los txhim kho kev txawj ntse. Cov qauv no ua ke nrog CDP choline sodium hmoov nrog alpha-GPC los tsim ib qho ntxiv uas yuav pab txhawb lub hlwb kev noj qab haus huv thiab kev txawj ntse.
- Citicoline + caffeine: Caffeine yog ib qho stimulant uas yuav pab tau kom ceev faj thiab ua kom pom tseeb. Cov qauv no ua ke nrog CDP choline sodium hmoov nrog caffeine los tsim ib qho ntxiv uas yuav pab txhim kho kev puas siab puas ntsws thiab qib zog.
- Citicoline + L-theanine: L-theanine yog ib qho amino acid uas muaj nyob rau hauv cov tshuaj yej ntsuab thiab ntseeg tau tias muaj cov nyhuv calming ntawm lub hlwb. Cov qauv no ua ke nrog CDP choline sodium hmoov nrog L-theanine los tsim ib qho ntxiv uas yuav pab txo qis kev ntxhov siab thiab txhawb kev so.
- Citicoline + B- cov vitamins: B- cov vitamins yog cov khoom noj tseem ceeb uas tseem ceeb rau kev tsim hluav taws xob thiab kev paub txog kev ua haujlwm. Cov qauv no ua ke nrog CDP choline sodium hmoov nrog B- cov vitamins los tsim ib qho ntxiv uas yuav pab txhawb nqa tag nrho lub zog thiab lub hlwb noj qab haus huv.
- Citicoline + acetyl-L-carnitine: Acetyl-L-carnitine yog ib qho amino acid uas tseem ceeb rau kev tsim hluav taws xob thiab kev txawj ntse. Cov qauv no ua ke nrog CDP choline sodium hmoov nrog acetyl-L-carnitine los tsim ib qho ntxiv uas yuav pab txhawb lub hlwb kev noj qab haus huv, qib zog, thiab kev txawj ntse.
Qhov twg yuav Citicoline CDP Choline hmoov?
Raws li lub ntiaj teb no renowned raw khoomtsim tawm, pebciticoline hmoovLub chaw ua haujlwm nruj me ntsis ua raws li USP43/NF38 cov qauv, tswj cov qib purity zoo ib yam ntawm ntau dua 98% nrog cov khoom zoo heev - rau -batch sib xws, tsis muaj impurities thiab cov khoom paug. Txawm koj tab tom nrhiavyuav citicolinesiv rau hauv capsules, ntsiav tshuaj, los yog kua formulations, los yog xav nug txogCDP choline nqirau bulk quotes, peb muab ib tug tag nrho traceable zoo tswj system backed los ntawm kev pab txhawb nqa.
Peb kuj txais tos ncaj qha nug; xaj rauyuav cdp choline muagtuaj yeem ntim tau yooj yim kom tau raws li koj cov kev xav tau tshwj xeeb. Los ntawm kev xaivKINTAIBIO®, koj tab tom xaiv ib qhov chaw rau Citicoline raw cov ntaub ntawv uas muaj siab purity, exceptional stability, thiab tag nrho traceability. Yog hais tias koj tab tom nrhiav ib tug txhim khu kev qha tsum ntawmCiticoline CDP Choline hmoov, thov koj xav tiv tauj peb ncaj qha ntawmsales@kintaibio.com.
Yog tias koj xav yuav siab - zooBulk Citicoline hmoovthov koj xav tiv tauj peb ntawmSales@Kintaibio.Comlos yog tawm tswv yim nyob rau nplooj ntawv tom ntej.
Cim npe nrov: Citicoline CDP Choline hmoov, Tuam Tshoj Citicoline CDP Choline hmoov manufacturers, lwm tus neeg, Hoobkas
