Gotu kola, tseem hu ua Centella asiatica, yog ib tsob nroj uas muaj hnub nyoog uas tau siv los ua tshuaj rau ntau pua xyoo, tshwj xeeb hauv Ayurvedic thiab Suav tshuaj. Cov nroj tsuag no tau txais kev saib xyuas dav dav rau nws cov txiaj ntsig kho mob, suav nrog nws lub peev xwm ua kom muaj peev xwm txhim kho daim tawv nqaij noj qab haus huv thiab zoo li qub.Gotu kola extract, muab tau los ntawm nplooj thiab stems ntawm cov nroj tsuag, tau kawm ntau heev rau nws cov active compounds thiab lawv muaj peev xwm yuav absorbed los ntawm daim tawv nqaij.
Kev sib xyaw ua ke thiab cov tshuaj nquag
Gotu kola extract yog nplua nuj nyob rau hauv ntau yam bioactive tebchaw, nrog rau triterpenoids, saponins, thiab flavonoids. Lub luag haujlwm tseem ceeb hauv lub luag haujlwm rau cov txiaj ntsig ntawm daim tawv nqaij ntawm gotu kola extract yog cov triterpenoids, xws li asiatic acid, madecassic acid, thiab asiaticoside (Bylka li al., 2013). Cov triterpenoids ntseeg tau tias muaj cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob antioxidant, thiab qhov txhab kho qhov txhab, ua rau lawv muaj kev txaus siab rau kev siv tshuaj pleev ib ce (Hashim li al., 2011).
Tsis tas li ntawd, cov saponins pom nyob rau hauv gotu kola extract, xws li centelloside thiab madecassoside, kuj tau kawm txog lawv lub peev xwm los txhim kho daim tawv nqaij permeability thiab pab txhawb kev nqus ntawm cov khoom xyaw nquag (Tenni li al., 1988). Cov tebchaw no tuaj yeem cuam tshuam nrog daim tawv nqaij lipid bilayer, uas tuaj yeem txhim kho daim tawv nqaij ua haujlwm tsis zoo thiab tso cai rau kev nkag mus zoo dua ntawm cov tshuaj nquag.
Kev tshawb fawb ntawm daim tawv nqaij
Ntau qhov kev tshawb fawb tshawb fawb tau tshawb xyuas lub peev xwm ntawm gotu kola extract thiab nws cov tshuaj nquag nkag mus rau ntawm daim tawv nqaij barrier. Hauv kev tshawb fawb los ntawm Bian et al. (2012), lub in vitro daim tawv nqaij permeation ntawm asiatic acid thiab madecassic acid los ntawm ib tug gel-raws li formulation raug soj ntsuam. Cov txiaj ntsig tau pom tias ob lub tebchaw tuaj yeem nkag mus rau ntawm daim tawv nqaij, nrog rau asiatic acid ua kom pom qhov permeation ntau dua. Cov kev tshawb pom zoo sib xws tau tshaj tawm los ntawm Mallavarapu li al. (2019), leej twg tshawb xyuas daim tawv nqaij nqus ntawm cov tshuaj pleev ib ce gotu kola extract-muaj formulation nyob rau hauv ib qho kev kawm ex vivo siv porcine daim tawv nqaij. Txoj kev tshawb no tau qhia tias cov tshuaj nquag, tshwj xeeb tshaj yog asiaticoside, tuaj yeem nkag mus rau ntawm daim tawv nqaij zoo.
Mechanisms ntawm Absorption
Lub peev xwm mechanisms uasgotu kola extractthiab nws cov active compounds tej zaum yuav absorbed los ntawm daim tawv nqaij nrog ib tug ua ke ntawm passive diffusion thiab carrier-mediated thauj. Lub lipophilic xwm ntawm triterpenoids, xws li asiatic acid thiab madecassic acid, tso cai rau lawv faib mus rau hauv lub stratum corneum, txheej txheej ntawm daim tawv nqaij, thiab ces diffuse los ntawm daim tawv nqaij barrier (Tenni li al., 1988). Tsis tas li ntawd, cov saponins tam sim no nyob rau hauv gotu kola extract tuaj yeem txhim kho daim tawv nqaij permeability los ntawm kev cuam tshuam nrog daim tawv nqaij lipid bilayer, muaj peev xwm tsim cov pores ib ntus lossis cov channel uas pab txhawb kev nkag mus ntawm cov tshuaj nquag (Bian li al., 2012).
Permeation Enhancers thiab Formulation Factors
Txhawm rau txhim kho daim tawv nqaij nkag mus ntawm gotu kola extract, ntau yam kev txhim kho permeation thiab cov tswv yim tsim tau raug tshawb nrhiav. Cov kev tshawb fawb tau tshawb fawb txog kev siv tshuaj ua kom muaj zog, xws li propylene glycol thiab dimethyl sulfoxide (DMSO), txhawm rau ua kom cov tawv nqaij permeability thiab pab txhawb kev nqus ntawm gotu kola cov tshuaj nquag (Rani et al., 2011). Tsis tas li ntawd, kev koom ua ke ntawm gotu kola extract rau hauv kev xa khoom sib txawv, xws li microemulsions, liposomes, thiab nanoparticles, tau pom tias txhim kho nws cov tawv nqaij nkag mus thiab bioavailability (Mallavarapu li al., 2019; Panchal li al., 2014).
Cov txiaj ntsig zoo rau daim tawv nqaij noj qab haus huv
Cov txiaj ntsig zoo ntawm gotu kola extract rau cov tawv nqaij noj qab haus huv feem ntau yog vim nws cov tshuaj nquag, tshwj xeeb yog triterpenoids. Cov tebchaw no tau cuam tshuam nrog ntau yam kev pab cuam ntawm daim tawv nqaij, xws li txhim kho qhov txhab zoo, txo qhov mob, thiab txhim kho collagen synthesis (Bylka li al., 2013; Hashim li al., 2011). Ntxiv thiab,gotu kola extracttau kawm txog nws lub peev xwm los txhim kho daim tawv nqaij elasticity, txo qhov pom ntawm wrinkles, thiab muab kev tiv thaiv antioxidant tiv thaiv ib puag ncig kev ntxhov siab (Tenni li al., 1988).
Kev txiav txim siab txog kev nyab xeeb thiab ceev faj
Thaum gotu kola extract feem ntau pom tias muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce, muaj qee qhov kev xav txog kev nyab xeeb kom paub txog. Kev ua xua, xws li khaus tawv nqaij lossis tiv thaiv kab mob dermatitis, tau tshaj tawm rau qee tus neeg (Mallavarapu li al., 2019). Nws yog ib qho tseem ceeb uas yuav tau ua qhov kev ntsuam xyuas thaj thiab sab laj nrog cov kws kho mob ua ntej siv cov khoom muaj txiaj ntsig ntawm gotu kola, tshwj xeeb tshaj yog rau cov tib neeg uas paub txog rhiab heev lossis ua xua. Tsis tas li ntawd, cov poj niam cev xeeb tub los yog pub niam mis yuav tsum tau ceev faj, vim tias kev nyab xeeb ntawm cov tshuaj pleev gotu kola extract thaum cev xeeb tub thiab lactation tsis zoo-tsim (Bylka et al., 2013).
Kev siv tswv yim thiab cov qauv tsim khoom
Gotu kola extractFeem ntau pom muaj nyob rau hauv ntau yam khoom tu tawv nqaij, suav nrog cov tshuaj pleev, tshuaj pleev, tshuaj pleev, thiab roj. Cov khoom no feem ntau yog muag rau lawv lub peev xwm los txhim kho daim tawv nqaij noj qab haus huv, txo cov tsos ntawm cov kab zoo thiab wrinkles, thiab txhawb nqa lub ntsej muag hluas dua. Thaum xaiv gotu kola extract-muaj cov khoom, nws yog ib qho tseem ceeb uas yuav tau xav txog cov formulation thiab cov concentration ntawm cov active compounds kom paub tseeb tias zoo haum thiab cov kev pab cuam.
Cov Lus Qhia Txog Kev Tshawb Fawb Yav Tom Ntej
Thaum cov kev tshawb fawb uas twb muaj lawm ntawm daim tawv nqaij nqus ntawm gotu kola extract tau cog lus, tseem muaj qhov chaw rau kev tshawb nrhiav ntxiv. Cov kev tshawb fawb yav tom ntej tuaj yeem tsom mus rau kev soj ntsuam cov txiaj ntsig ntev thiab kev nyab xeeb ntawm tshuaj pleev gotu kola extract hauv tib neeg kev sim tshuaj, nrog rau kev tshawb nrhiav cov txiaj ntsig muaj txiaj ntsig ntawm kev sib txuas ntawm gotu kola extract nrog rau lwm cov khoom siv tawv nqaij. Tsis tas li ntawd, kev tshawb fawb txog kev txhim kho cov txheej txheem xa tawm tshiab, xws li kev hloov pauv hloov pauv lossis cov txheej txheem iontophoretic, tuaj yeem pab txhim kho cov tawv nqaij nkag mus thiab bioavailability ntawm gotu kola cov tshuaj nquag.
Xaus
Hauv kev xaus, cov pov thawj tam sim no qhia tiasgotu kola extracttuaj yeem nqus tau zoo los ntawm daim tawv nqaij, feem ntau yog vim lipophilic xwm ntawm nws cov nquag triterpenoid tebchaw thiab lub peev xwm permeability-txhim kho cov khoom ntawm saponins. Txawm hais tias xav tau kev tshawb fawb ntxiv kom nkag siab txog cov txheej txheem thiab cov txiaj ntsig ntev ntawm cov tshuaj pleev gotu kola extract, cov kev tshawb fawb muaj qhia tias nws muaj peev xwm los ua cov khoom muaj txiaj ntsig hauv cov tshuaj pleev ib ce, muab ntau yam txiaj ntsig zoo rau cov tawv nqaij noj qab haus huv thiab zoo nkauj. .
PebCentella Asiatica Extract Powder Bulktau txais kev qhuas zoo los ntawm cov neeg siv khoom. Yog tias koj xav paub ntau ntxiv txog cov khoom no, thov hu rau dawbSales@Kintaibio.Com.
Cov ntaub ntawv
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