Echinacea yog perennial herbaceous nroj tsuag nyob rau hauv lub genusEchinaceanyob rau hauv tsev neeg Asteraceae; ib txwm nyob rau North America, nws muab nws lub npe los ntawm nws qhov txawv ntshav, lub khob hliav qab - zoo li paj paj. Raws li thaum ntxov li ob peb centuries dhau los, Cov Neeg Qhab Asmeskas tau siv nws los kho qhov txhab, hais txog kab tom, thiab txo qhov o - keeb kwm nplua nuj ntawm kev siv tshuaj ntsuab uas tau tsim lub hauv paus rau nws txoj kev loj hlob hauv cov khoom tu tawv nqaij niaj hnub.Echinacea extract hmoovyog tsim los ntawm kev rho tawm cov nroj tsuag cov khoom xyaw nquag siv cov kuab tshuaj-xws li ethanol- ua raws li kev ua kom huv thiab ziab kom ua tiav cov hmoov zoo.
Covechinacea purpurea extract hmoovtsim los ntawmKINTAIBIO®yog muab rho tawm los ntawm cov zaub mov -qib cov kuab tshuaj- xws li ethanol thiab cov dej huv huv - dhau ntawm cov txheej txheem kub reflux. Tom qab ntawd nws dhau mus pom, concentration, thiab tshuaj tsuag - kom qhuav kom tau txais cov hmoov txheem. Cov khoom nthuav tawm raws li cov hmoov zoo xws li xim ntawm lub teeb xim av mus rau xim av. Ntau yam kev qhia tshwj xeeb muaj los ua kom tau raws li cov neeg siv khoom xav tau, suav nrog tag nrho cov ntsiab lus phenol ntawm2%( kuaj pom ntawmHPLC) lub4%( kuaj pom ntawmUV), thiab chicoric acid cov ntsiab lus ntawm1%, 2%, los yog4%( kuaj pom ntawmHPLC). Cov khoom no yog siv dav hauv kev lag luam xws li kev tu tawv nqaij thiab tshuaj pleev ib ce.thov tiv tauj peb pab pawg muag khoom:sales@kintaibio.com.
Yuav ua li cas Echinacea Extract ua haujlwm rau daim tawv nqaij: Mechanisms of Action and Chemical Targets
Inhibition ntawm Lipoxygenase thiab Cyclooxygenase
Echinacea extract ncaj qha inhibits qhov kev ua ntawm 5-lipoxygenase (5-LOX), yog li txo cov synthesis ntawm muaj zog inflammatory mediators xws li leukotrienes. Ib txhij, nws inhibits cyclooxygenase (COX) kev ua haujlwm-txo prostaglandin synthesis-yog li thaiv ntau txoj hauv kev ntawm lawv qhov chaw enzymatic. Cov kev tshawb fawb hauv vitro tau pom tiasEchinacea Purpurea Extract hmoovtuaj yeem txo cov qib IL-6 tso tawm los ntawm cov kab mob inflammatory los ntawm 30% -50%.
Kev txo qis ntawm Pro-inflammatory Cytokine Expression thiab tso tawm hauv Keratinocytes
Echinacea extracttxo qis ob qho tib si mRNA qhia theem thiab cov protein tso tawm ntawm pro-inflammatory cytokines IL-6 thiab IL-8 hauv poly(I:C)-stimulated keratinocytes. Hauv cov qauv pob txuv, microbial stimulation induces copious secretion ntawm IL-6 thiab IL-8; echinacea purpurea extract hmoov ua kom rov qab cov txiaj ntsig no, rov ua kom cov qib cytokine rau lawv cov kab hauv qab.
Alleviation ntawm tam sim Hypersensitivity Reactions
Cov roj tsis hloov pauv thiab cov khoom siv terpene ua rau cov hlwb mast inhibit qhov tso tawm ntawm -hexosaminidase (ib qho cim enzyme rau mast cell degranulation) thiab txo cov tshuaj histamine tso tawm. Qhov no ua rau muaj txiaj ntsig zoo rau cov tsos mob ua xua -xws li daim tawv nqaij liab, kub hnyiab, thiab khaus- ntawm lawv qhov chaw. Cov kev tshawb fawb tau qhia tiasEchinacea extracttuaj yeem txo qhov khaus thiab erythema tshwm sim los ntawm kev tso tawm histamine.
Qhov chaw:https://www.sciencedirect.com/science/article/pii/S2667142524000411
Kev txo qis ntawm TNF- thiab PGE-2 Kev nthuav qhia
Cov alkylamide Cheebtsam downregulate phosphorylation ntawm p38, ERK 1/2, thiab STAT 3, nrog rau cov NF-κB signaling pathway. Qhov no ua rau txo qis hauv kev qhia ntawm cyclooxygenase-2 (COX-2) thiab, yog li ntawd, txo qis hauv PGE-2 synthesis; Tib lub sijhawm, nws inhibits qhov kev qhia ntawm TNF- . TNF- ua haujlwm tseem ceeb ntawm cov kab mob inflammatory cascade, ua haujlwm sib koom ua ke nrog PGE-2 los tsav cov tawv nqaij o thiab mob rhiab heev.
Kev tshem tawm ntawm DPPH Dawb Radicals; Antioxidant thiab Anti-Photoaging Effects
Echinacea Purpurea Extract hmoovyog nplua nuj nyob rau hauv polyphenolic thiab flavonoid compounds. DPPH dawb radical scavenging kev soj ntsuam tau pom tias nws cov ORAC cov tshuaj tiv thaiv antioxidant muaj peev xwm ncav cuag li 15,000 μmol TE / g. Cichoric acid nws tus kheej muaj zog antioxidant zog; nws zoo neutralizes dawb radicals thiab mitigates DNA puas rau cov tawv nqaij hlwb tshwm sim los ntawm ultraviolet hluav taws xob thiab ib puag ncig muaj kuab paug. Tsis tas li ntawd, ethanolic extract tau muab los ntawmEchinaceanthuav tawm cov kev ua haujlwm antioxidant muaj zog dua li nws cov dej sib xyaw ua ke, ua kom pom qhov zoo tshaj plaws dawb radical scavenging muaj peev xwm thiab ferric -txo lub zog antioxidant (FRAP).
Txhim kho Epidermal Tag Nrho Lipid, Ceramide, thiab Cholesterol Cov ntsiab lus
Kev tshawb nrhiav ob - qhov muag tsis pom kev kho mob tau qhia tias tom qab 15 hnub ntawm kev siv cov tshuaj nplaum uas muajEchinacea extract, cov neeg kawm tau pom cov qib siab dua ntawm tag nrho cov epidermal lipids, ceramide EOS, thiab cov roj cholesterol piv rau cov qib hauv qab; Tsis tas li ntawd, tus naj npawb ntawm intercellular lipid lamellae nyob rau hauv qhov chaw intercellular tau nce ntau. Ex vivo tawv qauv kev tshawb fawb ntxiv qhia tiasechinacea purpurea extract hmoovupregulates qhov kev qhia ntawm nruj hlws ris protein Claudin-1 los ntawm kwv yees li 27%, yog li ntxiv ntxiv dag zog rau daim tawv nqaij lub cev barrier muaj nuj nqi.
Kev tiv thaiv zoo tiv thaiv ultraviolet hluav taws xob
Echinacoside, ib qho tseem ceeb ntawm Echinacea, tuaj yeem ua rau UVB- ntxias cov tawv nqaij puas tsuaj los ntawm kev xaiv inhibiting TRPV3 raws hauv daim tawv nqaij.Echinacea extract hmoovtxo DNA strand lov nyob rau hauv daim tawv nqaij hlwb, txo txoj kev pheej hmoo ntawm post-sunburn erythema thiab hyperpigmentation, thiab ib txhij tiv thaiv dermal collagen los ntawm oxidative degradation. Cichoric acid nws tus kheej kuj ua lub luag haujlwm tiv thaiv UV- ua rau cov tawv nqaij puas thiab txhawb cov tawv nqaij cov txheej txheem tiv thaiv ntuj.
echinacea purpurea extract cov txiaj ntsig ntawm daim tawv nqaij
Anti-Kev Tiv Thaiv Kev Laus thiab Kev Tiv Thaiv Thaum Ntxov
Flavonoid cov ntsiab lus nyob rau hauvEchinacea purpurea extract hmoovinhibit qhov kev ua ntawm collagenase thiab elastase, yog li txo qis collagen. Nws cov khoom siv polysaccharide txhawb nqa fibroblast proliferation thiab txhim kho daim tawv nqaij elasticity. Nws muaj kev tiv thaiv dual tiv thaiv kev yees duab los ntawm cov dawb radical scavenging thiab los tiv thaiv - cov txheej txheem inflammatory, thiab muab kev tiv thaiv neuroprotection ntawm TRPV3 channel txoj kev.
Daim tawv nqaij Barrier Kho
Echinacea extractnce cov ntsiab lus epidermal ntawm tag nrho cov lipids, ceramides, thiab cov roj cholesterol. Nws txhim kho kom muaj nuj nqis ntawm intercellular lipid lamellae thiab upregulates qhov kev qhia ntawm nruj hlws ris proteins. Nws cov polysaccharide molecules, structurally zoo ib yam li daim tawv nqaij lub ntuj moisturizing yam, tsim ib tug tiv thaiv zaj duab xis locks nyob rau hauv noo noo. Qhov kev ua no tiv thaiv kev ruaj ntseg ntawm sebum zaj duab xis thiab txo cov dej tsis zoo (TEWL).
Qhov chaw:https://www.sciencedirect.com/science/article/pii/S2950306X2500055X
Soothing thiab Anti-Inflammatory Effects
Echinacea purpurea hmoovExtract kuj inhibits lipoxygenase kev ua haujlwm thiab tso tawm histamine. Nws txo qis kev qhia ntawm IL-6, IL-8, TNF- , thiab PGE-2. Nyob rau hauv cov ntaub so ntswg kab lis kev cai qauv, Echinacea extract tau pom tias yuav alleviate inflammatory edema nyob rau hauv ib tug npaum li cas ntawm koob tshuaj. Nws yog tsim rau siv rau ntawm daim tawv nqaij rhiab heev los txo qhov liab, txo qhov khaus, thiab pab tswj kev mob ntev.
Dej-Oil Balance and Acne Control
Cov phenolic acid Cheebtsam ntawmEchinacea extract hmoovtswj sebum secretion thiab inhibit qhov kev loj hlob ntawm cov kab mob xws li Propionibacterium acnes. Nws cov khoom siv polysaccharide muab hydration thiab moisturization, yog li tswj cov tawv nqaij cov dej - roj sib npaug. Echinacea extract tuaj yeem thim rov qab pob txuv tag nrho- cuam tshuam txog kev tso tawm ntawm IL-6 thiab IL-8, kho cov qib cytokine mus rau lawv cov hauv paus ntsiab lus.
Txhawb Txoj Kev Kho Hniav thiab Kho daim ntaub so ntswg
Echinacoside, uas yog ib qho tseem ceeb, txhawb nqa keratinocyte proliferation thiab tsiv teb tsaws los ntawm kev ua kom ERK signaling pathway; in vitro khawb kev soj ntsuam tau pom tias nws ua kom lub qhov txhab kaw los ntawm 20-30% piv rau pawg tswj hwm. Cov kev tshawb fawb tau lees paub tiasEchinacea ethanol extractTxhim kho qhov txhab kho qhov txhab muaj peev xwm hauv cov qauv tsiaj, thaum tib lub sijhawm txo qis IL-6 qhia, txhawb nqa IL-10 kev qhia, thiab txhawb nqa angiogenesis thiab collagen deposition. Tsis tas li ntawd, nws tiv thaiv fibroblasts los ntawm kev puas tsuaj oxidative thiab txhawb kev tsim cov ntaub so ntswg granulation.
Whitening thiab Brightening
Cov ntaub so ntswg-culturedEchinacea extractmuaj peev xwm inhibit melanin synthesis nyob rau hauv B16 melanoma hlwb nyob rau hauv ib koob tshuaj -nyob rau tib lub sij hawm scavenging dawb radicals; Nws kuj inhibits tyrosinase kev ua haujlwm.
echinacea extract phiv thiab kev nyab xeeb
- Echinacea purpurea extract hmoovmuaj keeb kwm ntev ntawm daim ntawv thov kev nyab xeeb hauv cov khoom tu tawv nqaij thiab feem ntau lees paub tias muaj kev nyab xeeb (GRAS).
- Hauv kev sim tshuaj, cov tshuaj nplaum thiab cov gels uas muaj Echinacea extract tsis ua rau cov tawv nqaij khaus khaus, yog li lees paub tias lawv muaj kev nyab xeeb thiab tsis yog - khaus xwm.
- Nco tseg:Cov neeg uas muaj kev fab tshuaj rau cov nroj tsuag hauv tsev neeg Asteraceae (xws li ragweed, chrysanthemums, dandelions, thiab lwm yam) yuav tsum tau ceev faj thaum siv cov khoom no.
- Nws raug nquahu kom cov neeg siv khoom ua qhov ntsuas patch kom paub tseeb tias muaj kev nyab xeeb ua ntej tshaj tawm lawv cov khoom tiav.
- Cov tib neeg uas muaj cov tawv nqaij rhiab yuav tsum ua qhov me me - kuaj thaj chaw (xws li, qab pob ntseg lossis ntawm dab teg sab hauv) rau 48 teev ua ntej lawv pib siv.
- cev xeeb tubCov poj niam, niam pub niam mis, thiab cov neeg muaj kab mob autoimmune raug qhia kom sab laj nrog kws kho mob ua ntej siv.
Tuam Tshoj echinacea purpurea extract hmoov tsum / chaw tsim tshuaj paus
echinacea extract hmoovinfusestu tawv nqaijcov khoom uas muaj ntau-seem tus nqi los ntawm nws cov natural bioactivity. Nws cov txiaj ntsig tseem ceeb tsis yog nyob rau hauv qhov kev ua tau zoo ntawm tus kheej cov khoom, tab sis tseem ceeb dua hauv kev sib koom ua ke ntawm ntau yam khoom xyaw: isobutylamides phiaj CB2 receptors; chicoric acid scavenges dawb radicals thiab inhibits hyaluronidase; thiab polyphenols ua haujlwm hauv kev hais kwv txhiaj nrog alkylamides los tiv thaiv kev mob o - sib sau ua ke tsim kom muaj cov txheej txheem dav dav rau kev tswj cov tawv nqaij ecosystem.
Raws li qhov tshwj xeebtsim tawmntawmTuam Tshoj echinacea purpurea extract hmoov, KINTAIBIO®tau mob siab rau muab cov khoom siv zoo- zoo, cov khoom siv raw khoom zoo, ua tiav los ntawm "ib- nres" cov kev pabcuam kev pabcuam (nrog rau cov qauv tsim cov lus pom zoo, kev pabcuam kev sojntsuam, thiab ntau dua). Txawm koj xav taubulk Echinacea extract hmoovrau cov khoom noj khoom haus, kev tsim khoom noj khoom haus, lossis cov khoom xyaw kom zoo nkauj, peb muaj peev xwm muab cov khoom lag luam wholesale. Thov koj xav tiv tauj peb rau cov ntaub ntawv khoom tshiab:sales@kintaibio.com.
