Ergothioneine Skincare: Cov txiaj ntsig, siv, thiab nws ua haujlwm li cas

Raws li cov neeg siv khoom txaus siab rau kev saib xyuas tawv nqaij antioxidant, kev tiv thaiv kev yees duab, thiab kev noj qab haus huv ntawm daim tawv nqaij txuas ntxiv, Ergothioneine (EGT) tau tshwm sim los ua ib qho tseem ceeb ntawm cov khoom xyaw hauv tshuaj pleev ib ce R & D. Reactive Oxygen Species (ROS)-tsim los ntawm UV raug, ib puag ncig muaj kuab lom, thiab cov txheej txheem ntawm cov cellular metabolic- tuaj yeem ua rau oxidative kev nyuaj siab. Qhov no cuam tshuam qhov kev ua haujlwm ntawm daim tawv nqaij thiab cov kab mob extracellular, ua rau muaj teeb meem xws li kev yees duab, kev hloov ntawm daim tawv nqaij, thiab kev puas tsuaj rau daim tawv nqaij barrier. Yog li ntawd, cov khoom xyaw uas muaj peev xwm koom nrog hauv kev tiv thaiv cellular antioxidant muab txoj hauv kev zoo rau kev txhim kho cov tshuaj tiv thaiv tawv nqaij tshiab.

Raws li ib tug kws muab khoom ntawmErgothioneine hmoov, KINTAIBIO^®muab cov ntaub ntawv khoom thiab kev txhawb nqa rau B2B cov neeg siv khoom thoob ntiaj teb. Cov npe tshuaj pleev ib ce, cov tsim qauv tsim, thiab cov neeg yuav khoom nyoos raug caw tuaj koomsales@kintaibio.comthov cov ntaub ntawv qhia txog L-Ergothioneine, suav nrog Daim Ntawv Pov Thawj Kev Ntsuam Xyuas (COA), cov khoom tshwj xeeb, Cov Ntaub Ntawv Cov Ntaub Ntawv (TDS), thiab Cov Ntaub Ntawv Kev Nyab Xeeb (SDS).

Ergothioneine yog ib txwm tshwm sim, muaj sulfur-muaj derivative ntawm cov amino acid histidine, pom abundantly nyob rau hauv edible fungi xws li nceb. Tsis zoo li qee cov antioxidants uas ua haujlwm feem ntau los ntawm kev tshem tawm cov dawb radicals ncaj qha, ergothioneine muaj cov txheej txheem tshwj xeeb ntawm cov cellular thauj. Kev tshawb fawb qhia tias nws muaj peev xwm tswj tau cellular antioxidant tiv thaiv txoj hauv kev; Piv txwv li, ib txoj kev tshawb nrhiav pom tias ergothioneine tuaj yeem txo qhov sib xyaw ntawm cov pa oxygen reactive (ROS), mitochondrial dysfunction, thiab qee hom kev puas tsuaj ntawm tes raug cuam tshuam los ntawm UVA cuam tshuam nrog rau kev ua kom Nrf2 / ARE antioxidant tiv thaiv txoj hauv kev. Thaum cov kev tshawb pom no muab lub hauv paus rau kev tshawb fawb ntxiv rau kev sivergothioneine hmoovhauv kev tu tawv nqaij, nws qhov kev ua tau zoo tiag tiag yuav tsum tau soj ntsuam los ntawm kev tshawb fawb ntawm cov tshuaj pleev ib ce thiab tib neeg cov ntsiab lus.

Nyob rau hauv cov ntsiab lus ntawm cov tshuaj pleev ib ce, ergothioneine ua hauj lwm raws li ib tug muaj peev xwm antioxidant muaj peev xwm siv nyob rau hauv serums, cream, lotions, thiab lwm yam kev tu tawv nqaij formulations. Txawm li cas los xij, kev ua haujlwm lom neeg ntawm cov khoom siv raw tsis sib npaug rau kev kho mob ntawm cov khoom tiav. Qhov kev ua tau zoo kawg yog nyob ntawm yam xws li qhov zoo ntawm cov khoom siv raw, nws cov concentration, tag nrho cov txheej txheem tsim, nws muaj peev xwm xa mus rau hauv daim tawv nqaij, thiab cov xwm txheej hauv qab cov khoom siv.

OCTN1-tseem hu ua ergothioneine transporter thiab encoded los ntawm SLC22A4 gene-pab txhawb kev nkag ntawm ergothioneine rau hauv cov hlwb tshwj xeeb. Kev tshawb fawb qhia tias qhov kev thauj mus los no ua rau tib neeg cov ntaub so ntswg tuaj yeem nqa thiab khaws ergothioneine, thaum tseem cuam tshuam rau nws txoj kev faib tawm hauv lub cev. Txawm li cas los xij, vim hais tias theem ntawm cov khoom thauj no sib txawv ntawm ntau hom cell, nws tsis tuaj yeem xav tias txhua lub cell ntawm daim tawv nqaij muaj peev xwm ua tau tib yam.

Lwm qhov chaw tseem ceeb ntawm kev tshawb fawb txog ergothioneine hauv daim tawv nqaij txhawj xeeb txog Nrf2/ARE antioxidant tiv thaiv txoj hauv kev. Nrf2 yog ib qho tseem ceeb transcriptional regulator koom nrog hauv cellular antioxidant teb; nws tswj hwm qhov kev qhia ntawm ntau yam noob uas cuam tshuam nrog kev tiv thaiv antioxidant, xws li HO-1 thiab NQO-1. Ib txoj kev tshawb fawb xyoo 2015 uas siv tib neeg keratinocyte qauv qhia tau hais tias kev kho ua ntej nrog ergothioneine tau cuam tshuam nrog kev txo qis ntawm UVA-induced reactive oxygen hom (ROS), txo qis cellular puas, thiab txhim kho Nrf2-mediated antioxidant teb.

Ergothioneine hmoovyog ntau tshaj li qhov sib xyaw ua ke uas qhia tau tias muaj peev xwm tshem tawm cov dawb radicals hauv kev sim; nws cov ntaub ntawv lom neeg muaj feem xyuam rau cov khoom thauj tshwj xeeb thiab cov txheej txheem uas cov hlwb teb rau oxidative kev nyuaj siab. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias thaum lub hlwb muaj peev xwm noj ergothioneine ntawm OCTN1, qhov no tsis tau lees tias ergothioneine hauv cov khoom siv tshuaj pleev ib ce tuaj yeem nkag mus rau daim tawv nqaij tiv thaiv kom ncav cuag dermis. Kev xa tawm dermal cuam tshuam los ntawm cov khoom xws li cov khoom siv hauv lub cev, lub tsheb tsim, qhov xwm txheej ntawm daim tawv nqaij, thiab txoj kev siv.

Antioxidant tiv thaiv Oxidative Stress

Oxidative stress yog hais txog qhov tsis sib xws ntawm kev tsim cov oxidizing cov neeg ua haujlwm-xws li cov pa oxygen reactive (ROS)- thiab cov cellular tiv thaiv kab mob. Thaum cov tawv nqaij raug ultraviolet (UV) hluav taws xob, cov pa phem, lossis lwm yam kev ntxhov siab ib puag ncig, cov qib ROS hauv lub cev tuaj yeem nce siab, ua rau muaj kev puas tsuaj rau cov roj ntsha xws li lipids, cov protein, thiab DNA. Ergothioneine tau txais kev saib xyuas vim nws cov tshuaj sulfur-muaj cov qauv tshuaj thiab cov khoom antioxidant. Cov kev tshawb fawb soj ntsuam tau pom tias nws tuaj yeem tshem tawm qee yam reactive oxygen thiab nitrogen hom, yog li txo oxidative kev puas tsuaj hauv cov qauv cellular.

Muaj peev xwm tiv thaiv UV-Induced tawv nqaij puas

UV hluav taws xob yog ib qho tseem ceeb ntawm ib puag ncig cuam tshuam rau kev noj qab haus huv ntawm daim tawv nqaij. UVA rays, tshwj xeeb tshaj yog, tuaj yeem nkag mus rau hauv cov epidermis thiab cuam tshuam cov hlwb thiab cov kab mob extracellular hauv lub dermis. Kev sib sau ntawm ROS tshwm sim los ntawm UVA raug tuaj yeem ua rau collagen degradation, hloov pauv hauv cellular muaj nuj nqi, thiab cov txheej txheem ntawm kev yees duab. Kev tshawb fawb soj ntsuam cov teebmeem ntawm ergothioneine ntawm UVA-vim kev puas tsuaj tau pom tias, nyob rau hauv qhov kev sim siab thiab irradiation tej yam kev mob kuaj, kho nrogergothioneine hmoovNws cuam tshuam nrog qis ROS qib, kev ua haujlwm ntawm tes ntau dua, txo qis apoptosis, thiab txhim kho mitochondrial muaj nuj nqi. Tsis tas li ntawd, kev txhim kho hauv Nrf2/ARE-mediated antioxidant tiv thaiv teb kuj tau pom.

Ergothioneine thiab tawv nqaij laus: Cov kab zoo, Wrinkles, thiab Collagen

Matrix metalloproteinase-1 (MMP-1) koom nrog hauv kev degradation ntawm hom I thiab hom III collagen. Ultraviolet (UV) hluav taws xob induces zus tau tej cov reactive oxygen hom (ROS), uas muaj peev xwm cuam tshuam cov kev taw qhia txoj kev-xws li lub AP-1 txoj kev-thiab txhawb cov kev ua ntawm tej yam matrix metalloproteinases. Yog li ntawd, txo oxidative kev nyuaj siab thiab kev hloov pauv txoj hauv kev cuam tshuam nrog collagen degradation tau dhau los ua qhov tseem ceeb ntawm kev tsom mus rau kev tshawb fawb ntawm cov khoom siv los tiv thaiv kev yees duab. Kev tshawb fawb siv tus qauv UVA-exposure nyob rau hauv tib neeg dermal fibroblasts tau qhia tias kev kho mob nrog ergothioneine yog txuam nrog attenuated AP-1 signaling, inhibited MMP-1 kev ua, txo degradation ntawm hom I procollagen, thiab ib qho kev txhim kho Nrf2-mediated antioxidant tiv thaiv teb.

Ergothioneine puas tuaj yeem pab ua kom tawv nqaij?

Kev hloov pauv ntawm daim tawv nqaij thiab kev loj hlob ntawm hyperpigmentation koom nrog ntau yam txheej txheem, suav nrog kev sib txuas, thauj, faib, thiab cov metabolism ntawm melanin. UV hluav taws xob tuaj yeem ua rau cov tawv nqaij hloov pauv los ntawm kev cuam tshuam melanocytes thiab inducing oxidative tshua; o thiab hauv zos cellular signaling kuj yuav pab tau rau qee hom hyperpigmentation. Kev tshawb fawb qhia tias ergothioneine tuaj yeem cuam tshuam kev ua haujlwm ntawm tyrosinase hauv kev sim. Tsis tas li ntawd, nws tau raug pom tias daim ntawv thov kev tsim muaj 0.1% ergothioneine ua rau kev txhim kho ntawm UV-induced tawv nqaij pigmentation markers nyob rau plaub lub lis piam.

Muaj peev xwm tiv thaiv kab mob rau cov tawv nqaij rhiab heev

Muaj ib qho kev sib txuas ntawm oxidative kev nyuaj siab thiab inflammatory teb. Cov hluav taws xob ultraviolet (UV) thiab lwm yam kev ntxhov siab ib puag ncig tuaj yeem ua rau cov khoom sib xyaw ntawm cov pa oxygen reactive (ROS) thiab cuam tshuam rau cellular signaling pathways-xws li AP-1 thiab MAPK-yog li ua rau muaj kev cuam tshuam txog kev mob. Muab hais tias ergothioneine tau pom cov teebmeem antioxidant hauv qee qhov kev tshawb fawb ntawm tes, cov kws tshawb fawb tseem tab tom tshawb nrhiav nws lub luag haujlwm tseem ceeb hauv kev hloov kho cov teeb meem ntsig txog mob. Ntau qhov kev tshuaj xyuas tau sau tseg cov kev tshawb fawb lom neeg ntawm ergothioneine hauv cov ntsiab lus ntawm daim tawv nqaij, sib tham txog nws txoj kev sib txuas rau oxidative kev nyuaj siab, inflammatory signaling, thiab kev tiv thaiv ntawm daim tawv nqaij hlwb.

Kev koom ua ke ntawm ergothioneine rau hauv cov khoom siv tshuaj pleev ib ce yuav tsum tau ua tib zoo xav txog ntau yam, suav nrog kev npaj ua tau zoo, cov khoom siv raw, cov qauv sib xws, kev ruaj ntseg, thiab kev xa khoom ntawm daim tawv nqaij. Tam sim no, ergothioneine yog siv nyob rau hauv ntau hom tshuaj pleev ib ce, qhov twg nws feem ntau ua hauj lwm pab raws li ib tug auxiliary antioxidant muaj.

Ergothioneine hauv Serums, Creams, thiab lwm yam khoom kom zoo nkauj

Ergothioneine ua haujlwm zoo li cov tshuaj tiv thaiv antioxidant rau kev siv hauv cov tshuaj pleev ib ce, tshuaj pleev, tshuaj pleev ib ce, cov khoom kho qhov muag, thiab lwm yam kev kho mob ntawm daim tawv nqaij. Thaum tsim cov tshuaj tiv thaiv kab mob antioxidant, cov neeg tsim khoom yuav tsum tsom rau yam xws li ergothioneine lub solubility hauv aqueous systems, kev saib xyuas ntawm nws cov concentration, thiab nws compatibility nrog rau lwm yam khoom xyaw. Rau cov tshuaj pleev ib ce thiab tshuaj pleev ib ce, ntxiv kev xav-nrog rau cov txheej txheem emulsification, cov roj thiab cov theem aqueous, cov txheej txheem preservative, thiab kev xaiv ntawm cov khoom ntim-yuav tsum tau soj ntsuam rau lawv cov kev cuam tshuam rau qhov zoo ntawm cov khoom kawg.

Ergothioneine hmoovKuj tseem tuaj yeem muab tso rau hauv cov qauv ua ke nrog cov khoom xyaw xws li vitamin C (thiab nws cov derivatives), niacinamide, thiab ntau yam humectants. Muab hais tias vitamin C, niacinamide, thiab ergothioneine muaj cov tshuaj lom neeg sib txawv thiab tau txais kev txhawb nqa los ntawm ntau lub cev ntawm kev tshawb fawb txog tawv nqaij, kev sib xyaw ua ke yuav ua rau muaj ntau hom kev ua haujlwm. Txawm li cas los xij, qhov ua tau zoo ntawm cov kev sib xyaw ua ke no yuav tsum raug txheeb xyuas los ntawm kev sib raug zoo, kev ruaj ntseg, thiab kev ntsuas kev ua tau zoo ntawm cov khoom tiav.

Ergothioneine tau ua cov ntsiab lus tseem ceeb ntawm kev tshawb fawb hauv paus, nrog ntau yam kev tshuaj xyuas cov ntsiab lus ntawm nws cov antioxidant zog, cellular uptake mechanisms, thiab muaj peev xwm siv tau. Txawm li cas los xij, kev tshawb fawb txog kev siv tshuab thiab * hauv vitro * kev sim tsis tuaj yeem hloov pauv rau kev ntsuas kev nyab xeeb ntawm cov khoom siv tshuaj pleev ib ce tshwj xeeb. Cov tuam txhab npaj tsim cov khoom tshiab yuav tsum ua tib zoo tshuaj xyuas ntawm cov khoom siv raw zoo, ntsuas cov ntaub ntawv toxicological, thiab ua kev ntsuam xyuas kev nyab xeeb ntawm cov khoom tiav, raws li cov kev cai ntawm lub hom phiaj kev lag luam thiab cov khoom tshwj xeeb.

Cov teebmeem ntawm Ergothioneine hauv Skincare

Nws tsis tuaj yeem xav tias cov khoom tu tawv nqaij uas muaj ergothioneine yog qhov tshwm sim tsis yog khaus raws li cov khoom muaj cov tshuaj antioxidant. Kev ua siab ntev ntawm daim tawv nqaij tiag tiag tuaj yeem cuam tshuam los ntawm kev ua kom tiav, txoj kev thov, tus neeg mob ntawm daim tawv nqaij, thiab muaj lwm yam khoom xyaw. Rau cov neeg siv cov khoom uas muaj ergothioneine thawj zaug, nws raug nquahu kom ua raws li cov lus qhia ntawm cov khoom thiab, yog tias tsim nyog, ua qhov ntsuas patch. Yog tias mob liab liab, khaus khaus, kub hnyiab, lossis lwm yam kev tsis xis nyob tshwm sim, tsis txhob siv thiab nrhiav kev tawm tswv yim raws li cov tsos mob. Cov tib neeg uas paub txog kev ua xua rau cov khoom tsim tshwj xeeb yuav tsum ua tib zoo tshuaj xyuas cov npe tag nrho.

Ergothioneine yog sulfur-muaj histidine derivative tus yam ntxwv los ntawm ib tug tshwj xeeb cellular thauj mechanism thiab lub hauv paus ntawm kev tshawb fawb txog nws cov antioxidant zog. Cov kev tshawb fawb uas twb muaj lawm qhia tias nws muaj peev xwm txo tau UVA-induced oxidative cellular puas, tswj Nrf2-mediated antioxidant tiv thaiv, thiab cuam tshuam txoj hauv kev cuam tshuam nrog kev yees duab. Rau cov khoom xyaw kom zoo nkauj procurers, kev soj ntsuam kev tshawb fawb ntawmergothioneine hmoovyuav tsum mus dhau nws cov teebmeem antioxidant; nws tseem yuav tsum suav rau cov khoom siv raw zoo, cov txheej txheem kev sim, batch-to-batch zoo ib yam, cov ntaub ntawv kev txawj ntse, thiab kev sib raug zoo nrog cov qauv tshwj xeeb.

Pleurotus citrinopileatus Extract 1% Ergothioneine Powder

Pleurotus citrinopileatus Extract 1% Ergothioneine Powder

Raws li ib tug kws muab khoom ntawmergothioneine hmoov, KINTAIBIO^®muab cov ntaub ntawv cov khoom lag luam thiab kev txhawb nqa rau cov neeg siv khoom txawv teb chaws, cov npe tshuaj pleev ib ce, thiab cov khoom tsim tawm. Raws li cov kev cai siv tau thiab cov kev xav tau tshwj xeeb, kev siv ergothioneine tuaj yeem raug soj ntsuam rau cov ntawv thov hauv cov tshuaj pleev ib ce, cov khoom noj khoom haus, khoom noj khoom haus, thiab lwm yam khoom muaj feem xyuam. Thov koj xav tiv tauj peb ntawmsales@kintaibio.comyog xav paub ntxiv.