Cytisine yog ib qho alkaloid rho tawm los ntawm legumes, feem ntau los ntawmThermopsis lanceolatathiabSophora alopecuroides. Raws li ib feem ntawm agonist ntawm 4 2 nicotinic acetylcholine receptor, cytisine sib tw khi rau cov nicotine receptors, ua kom pom kev ua tau zoo thiab kev nyab xeeb zoo hauv kev pab cov neeg haus luam yeeb tawm nicotine. Nws cia siab tiasCytisiniclineyuav tau txais kev pom zoo los ntawm FDA hauv 2026, ua rau kev siv tshuaj kho mob thoob ntiaj teb.Kab lus no yuav muab cov kws kho mob thiab cov neeg siv khoom muaj peev xwm nrog cov ntaub ntawv ntawm cytisine, tshwj xeeb tshaj yog cov teeb meem tseem ceeb xws li kev noj tshuaj, contraindications, thiab kev sib cuam tshuam tshuaj.
Raws li tus kws tshaj lij cytisine raw khoom chaw tsim khoom,KINTAIBIO®tau cog lus los muab cov neeg siv khoom nrog siab -purity (99% HPLC) cytisine hmoov. Peb cov khoom siv cov txheej txheem extraction siab heev thiab ua tau raws li cov qauv thoob ntiaj teb. Yog koj tab tom nrhiav ibcytisine tus neeg muag khoomlos yog Hoobkas, thov hu rau peb ntawmsales@kintaibio.com.
Yuav ua li cas noj cytisine?
Standardized 25-hnub dosing regimen
| Hnub kho mob | Dosage zaus | Noj txhua hnub (ntawm 1.5 mg / units) | Lus hais | ||||||
| Hnub 1-3 | txhua 2 teev | 6 ntsiav tshuaj | Thawj zaug loading koob tshuaj | ||||||
| Hnub 4-12 | txhua 2.5 teev | 5 ntsiav tshuaj | Lub hom phiaj txiav tawm hnub teem rau hnub 5 | ||||||
| Hnub 13-16 | txhua 3 teev | 4 ntsiav tshuaj | Maj mam txo cov koob tshuaj | ||||||
| Hnub 17-20 | txhua 4-5 teev | 3 ntsiav tshuaj | Maj mam txo cov koob tshuaj | ||||||
| Hnub 21-25 | txhua 6 teev (1-2 zaug) | 2 ntsiav tshuaj | Kho koob tshuaj | ||||||
ORCA-2 Clinical Trial
ORCA-2 randomized tswj kev sim, luam tawm hauvJAMAhauv 2023, soj ntsuam cov tshuaj pharmacokinetic tshiab -raws li kev noj tshuaj. Qhov no yog peb pawg - pab pawg, ob npaug - qhov muag tsis pom, randomized tswj kev sim uas suav nrog 810 tus neeg haus luam yeeb txhua hnub, sib piv cov txiaj ntsig ntawm 6-lub lim tiam lossis 12-lub lim tiam kev kho mob (3 mg peb zaug ib hnub) nrog cov placebo.
Qhov chaw:https://pubmed.ncbi.nlm.nih.gov
Cov txiaj ntsig tau pom tias pab pawg kho mob 6 lub lis piam tau ua tiav biochemically validated tus nqi ntawm kev haus luam yeeb txuas ntxiv ntawm25.3%nyob rau hauv plaub lub lis piam dhau los ntawm kev kho mob (lub lis piam 3-6), ho siab tshaj qhov 4.4%hauv pawg placebo. Pab pawg kho mob 12 lub lis piam tau ua tiav qhov kev haus luam yeeb txuas ntxiv ntawm 32.6%nyob rau hauv plaub lub lis piam dhau los ntawm kev kho mob (lub lis piam 9-12), ntau dua li qhov7.0%hauv pawg placebo.
Qhov no qhia tau hais tias, ntxiv rau cov txheej txheem 25-hnub classic, cov kev kho mob ntev dua (6-12 lub lis piam) kuj qhia tau tias muaj txiaj ntsig zoo thiab ua kom ntev, muab ntau txoj hauv kev rau cov neeg haus luam yeeb nrog cov kev xav tau sib txawv.
Cytisine Drug Interactions
Sparteine hmoovfeem ntau yog excreted tsis hloov ntawm ob lub raum thiab yuav luag tag nrho bypassed los ntawm lub siab CYP450 enzyme system; Yog li ntawd, qhov kev pheej hmoo ntawm kev sib cuam tshuam tshuaj kho los ntawm CYP enzymes tsawg. Txawm li cas los xij, cov tshuaj hauv qab no tseem xav tau kev saib xyuas:
- Nrog nicotine thiab NRT cov khoom:Raws li txoj cai, kev siv cov tshuaj nicotine hloov pauv lossis lwm yam kev haus luam yeeb (xws li varenicline) tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob tshwm sim (xws li xeev siab thiab palpitations) vim muaj cov txheej txheem zoo sib xws, thiab yuav tsum zam.
- Nrog cov tshuaj antiretroviral: Ib daim ntawv tshaj tawm txog 2024 tau pom tias tsis muaj cov xwm txheej tsis zoo lossis kev hloov pauv hauv cov kab mob kis tau tshwm sim thaum twgCytisinicline hmoovtau siv ua ke nrog cov tshuaj HIV xws li bicretiva. Qhov no qhia tau hais tias qhov ua tau ntawm kev kho mob tseem ceeb cuam tshuam nrog cov tshuaj tiv thaiv kab mob metabolized los ntawm CYP450 enzymes tsawg.
- Nrog cov tshuaj antiepileptic:Cov kev tshawb fawb tsiaj tau pom tiasSophora Alopecuroides Extract CytisineTej zaum yuav inhibit qhov kev ua ntawm qee yam tshuaj tiv thaiv kab mob (xws li phenytoin, lamotrigine, thiab levetiracetam), thiab yuav tsum tau ceev faj thaum siv nws hauv tsev kho mob.
- Nrog hormonal contraceptives:Nws raug pom zoo tias cov poj niam uas muaj hnub nyoog me nyuam yaus siv cov tshuaj tiv thaiv zoo heev thaum noj cov tshuaj no. Rau cov neeg siv cov tshuaj tiv thaiv kab mob hormonal, nws raug nquahu kom siv cov txheej txheem kev tiv thaiv kab mob ntxiv kom ntseeg tau tias muaj txiaj ntsig zoo.
- Nrog varenicline:Ob leeg yog ib nrab 4 2 receptor agonists nrog cov txheej txheem zoo sib xws ntawm kev ua, thiab yuav tsum tau zam thaum siv ua ke.
Cytisine contraindications
Tsis muaj contraindications
- Cov poj niam cev xeeb tub thiab lactating:Vim tias cov nicotine receptors muaj nyob rau theem pib ntawm tib neeg lub hlwb kev loj hlob thiab kev nyab xeeb cov ntaub ntawv tsis muaj,Thermopsis Lanceolata Extract cytisineNws yog contraindicated thaum cev xeeb tub thiab lactation.
- Cov neeg mob uas muaj mob hnyav:Contraindicated nyob rau hauv cov neeg mob uas tsis ruaj tsis khov angina, tsis ntev los no myocardial infarction, kev kho mob tseem ceeb arrhythmias, tsis ntev los no stroke, advanced atherosclerosis, thiab uncontrolled hypertension.
Cov cim ceeb toom
- Mob raum mob hnyav:Vim hais tias cov tshuaj feem ntau yog tawm los ntawm ob lub raum, nws yog contraindicated nyob rau hauv cov neeg mob uas mob raum mob hnyav.
- Mob hlwb:Txoj kev txiav luam yeeb nws tus kheej yuav cuam tshuam nrog kev hloov mus ob peb vas; Cov neeg mob uas muaj teeb meem kev puas siab puas ntsws hnyav yuav tsum siv nws nyob rau hauv kev saib xyuas kev kho mob ze.
- Epilepsy:Contraindicated nyob rau hauv cov neeg mob uas muaj mob vwm.
Cytisine thiab cawv
Ntau qhov kev tshawb fawb tsiaj tau pom tias cytisine tuaj yeem txo qis kev haus cawv thiab "kev haus dej cawv" (tus qauv rov qab los) hauv cov nas, qhia txog nws lub peev xwm los kho kev haus cawv.Cawv thiab nicotine ob leeg ua rau tib yam nicotinic acetylcholine receptors (tshwj xeeb tshaj yog cov 4 2 subtype) nyob rau hauv lub hlwb nqi zog txoj kev (xws li ventral tegmental cheeb tsam). Raws li ib feem agonist ntawm no receptor,Sparteine hmoovtuaj yeem txo qhov kev ntshaw rau ob qho tib si nicotine thiab cawv los ntawm kev hloov txoj hauv kev no.
Tam sim no, thawj qhov qhia rau sparteine sulfate tseem haus luam yeeb. Nws txoj kev siv los kho kev haus cawv yog tseem nyob rau theem kev tshawb fawb thiab tseem tsis tau pom zoo. Nws raug pom zoo kom zam los yog txwv tsis pub haus cawv thaum nojSophora Alopecuroides Extract Cytisine.
Cytisine Adverse Reactions
Kev tsis zoo tshwm sim:Xws li kev hloov hauv qab los noj mov, kiv taub hau, chim siab, hloov mus rau hauv lub siab, ntxhov siab vim, pw tsaug zog cuam tshuam, mob taub hau, tachycardia, kub siab, qhov ncauj qhuav, xeev siab, kub hnyiab, cem quav, tawm pob, myalgia, thiab qaug zog.
Feem ntau cov tshuaj tiv thaiv me me
Cov tshuaj tiv thaiv no feem ntau yog me me mus rau nruab nrab thiab ib ntus, thiab qee cov tsos mob yuav cuam tshuam txog kev tshem tawm nicotine nws tus kheej.
qhov twg yuav cytisine hmoov?
Cytisinicline, nrog rau nws qhov zoo -txhais cov tshuaj pharmacological, cov txheej txheem ntau npaum li cas, thiab tsis tu ncua hloov kho siab - cov pov thawj kho mob, tau dhau los ua tus nqi - kev xaiv tshuaj noj haus kom zoo thiab nyab xeeb. Nws cov khoom tshwj xeeb pharmacokinetic ua rau muaj kev pheej hmoo tsawg ntawm kev sib cuam tshuam ntawm cov tshuaj.
Raws li cov neeg tsim khoom,KINTAIBIO®tsim tawmcytisine hmoovtau los ntawmThermopsis lanceolata/Sophora alopecuroidesnrog purity txog li99%. Peb tau cog lus tias yuav muab siab - zooThermopsis Lanceolata Extractthiab txuas ntxiv txhawb kev tshawb fawb-raws li cov txheej txheem kev thov kev kho mob. Peb pom zoo kom cov kws kho mob soj ntsuam tag nrho cov neeg mob cov tshuaj contraindications thiab cov tshuaj sib xyaw ua ke thaum sau ntawv, xaiv cov tshuaj noj kom tsim nyog, thiab ntxiv dag zog rau cov neeg mob kev kawm thiab ua raws li- kom ua kom muaj txiaj ntsig zoo tshaj plaws. Thov koj xav tiv tauj peb ntawmsales@kintaibio.comrau tus nqi thiab cov ntaub ntawv ntawm cov khoom.
