Puas yog quillaia extract muaj kev nyab xeeb: Siv, Cov Teeb Meem, thiab Txwv

Quillaja Bark Extractyog muab los ntawm lub puab tawv ntawm lubTsob ntoo tsob ntoo (Quillaja saponaria Molina). Raws li ib txwm muaj cov nroj tsuag-raws li surfactant nplua nuj nyob rau hauv triterpenesaponins, nws ua lub luag haujlwm tseem ceeb uas yog tus neeg sawv cev foaming thiab emulsifier hauv kev lag luam zaub mov thiab dej haus, thiab tseem tau nce ntxiv rau hauv cov qauv ntawm cov khoom tu tus kheej hauv cov tshuaj pleev ib ce sector. Thaum siv nyob rau hauv cov zaub mov pom zoo -qib txwv,Quillaja saponaria extractsuav tias yog kev nyab xeeb; nws qhov profile kev nyab xeeb tau txais kev lees paub kev tshawb fawb los ntawm lub koom haum tswj hwm thoob plaws ntau lub tebchaws. Txawm li cas los xij -raws li cov ntaub ntawv uas muaj ntau yam khoom siv ntuj tsim- ua rau muaj kev pheej hmoo ntau ntxiv (tshwj xeeb yog los ntawm loj - noj tshuaj ntawm qhov ncauj lossis kev tswj xyuas parenteral) tuaj yeem ua rau muaj kev phom sij txog kev nyab xeeb.

CovQuillaja Saponaria Extract hmoovtsim los ntawmKINTAIBIO^®nruj me ntsis ua raws li cov kev cai tswj hwm uas tsim los ntawm ob qho tib si thoob ntiaj teb thiab cov tub ceev xwm hauv tebchaws, yog li ua kom muaj kev nyab xeeb thiab kev tswj hwm ntawm peb cov khoom thiab tso lub hauv paus ruaj khov rau koj cov khoom lag luam thoob ntiaj teb kev txhim kho. Yog tias koj xav tau cov lus pom zoo tshwj xeeb lossis cov qauv rau kev sim, thov koj xav tiv tauj peb rau kev txhawb nqa ntxiv thiab cov ntaub ntawv khoom:sales@kintaibio.com.

Cov txheej txheem tseem ceeb hauv qab qhov qis qhov ncauj toxicity ntawmSaponins

Lub plab microbiota tuaj yeem hydrolyze saponins rau hauv aglycones thiab qab zib. Hemolytic saponins tsis tuaj yeem hla txoj hnyuv mucosa; Qhov tshwm sim no tuaj yeem raug ntaus nqi los ntawm kev tshem tawm sai ntawm cov plab hnyuv mucosal los ntawm cov txheej txheem ntawm epithelial turnover. Qhov ncauj toxicity tsawg ntawm saponins kuj tuaj yeem ua rau thaj tsam loj ntawm cov tsiaj nyeg plab hnyuv, uas ua rau kom muaj txiaj ntsig zoo ntawm kev noj cov saponins. Cov txheej txheem no piav qhia tias yog vim li cas tib yam tshuaj - uas ua rau muaj kev toxicity siab heev thaum noj cov tshuaj intravenously los yog subcutaneously - ua kom pom kev zam tau zoo thiab kev nyab xeeb thaum noj qhov ncauj.

Empirical Evidence for the Oral Safety ofQuillaja Saponaria Extract hmoov

Nws yog ib qho tseem ceeb uas yuav tsum tau hais qhia tias qhov tshuaj lom ntawm cov zaub mov - qibQuillaja bark extractFeem ntau txwv nws txoj kev siv raws li kev txhaj tshuaj adjuvant; Txawm li cas los xij, thaum siv qhov ncauj, qhov tshuaj lom no zoo li txo qis heev. Raws li kev tshawb fawb luam tawm, qhov mob qhov ncauj LD₅₀ rau nas yog 1625 mg / kg ntawm lub cev hnyav; Nyob rau hauv tib cov ntaub ntawv, qhov mob LD₅₀ qhov tseem ceeb rau cov hlab ntsha, intraperitoneal, thiab subcutaneous tswj tau raug tshaj tawm raws li 275, 275, thiab 650 mg / kg ntawm lub cev hnyav, raws li.

Hais txog kev mob toxicity ntev, ib txoj kev tshawb fawb uas muaj cov nas noj cov zaub mov ntxiv nrog 3.0% Quillaja bark extract rau 108 lub lis piam qhia tsis muaj qhov txawv txav hauv hematological lossis urinalysis tsis muaj, thiab tsis muaj pov thawj ntawm carcinogenicity. Ib yam li ntawd, ib txoj kev tshawb fawb txog TO- lim nas noj cov zaub mov ntxiv nrog 1.5%Quillaja Saponaria Extractrau 84 lub lis piam qhia tsis muaj kev hloov pauv hauv histopathological; Qhov Tsis Tau-Saib xyuas-Qhov Teeb Meem (NOEL) tau tsim los ntawm 0.5% ntawm cov khoom noj. Hauv 13-lub lim tiam kev tshawb fawb rov ua dua ntawm cov nas, NOEL tau txiav txim siab tias yog 0.6% ntawm cov khoom noj, tsis muaj kev hloov pauv histopathological pom tias yog vim li cas rau cov tshuaj ntsuam xyuas.

Saponins: Natural Constituents of the Human Diet

Saponins yog ib qho tseem ceeb tshaj plaws nyob rau hauv cov nroj tsuag, tshwm sim nyob rau hauv ntau tshaj 500 ntau hom nroj tsuag. Cov tebchaw no tshwm sim nyob rau hauv ntau yam nroj tsuag uas tib neeg noj txhua hnub-xws li qos yaj ywm, txiv lws suav, dos, legumes, tshuaj yej, thiab qee yam tshuaj ntsuab thiab txuj lom- nrog rau ntau cov qoob loo siv rau tsiaj pub. Tsis muaj cov ntaub ntawv qhia txog qhov tsis zoo ntawm kev yug menyuam uas tshwm sim los ntawm kev noj cov zaub mov uas muaj saponins; qhov no ntxiv txhawb kev soj ntsuam kev nyab xeeb ntawmsoapbark extractntawm zaub mov- qib kev siv qib.

Cov ntaub ntawv pov thawj ntawm Tsis yog -mutagenicity ntawmQuillaja saponaria bark extract

Ntau yam kev tshawb fawb mutagenicity muab ntxiv corroboration rau kev nyab xeeb ntawmQuillaja saponaria extract. Hauv kev ntsuam xyuas kab mob Salmonella cov kab mob hloov pauv, ntau cov tshuaj saponins uas tau muab rho tawm los ntawm alfalfa tsis pom muaj qhov nce ntxiv hauv cov cheeb tsam rov qab, txawm tias nyob rau hauv lub xub ntiag los yog tsis muaj kev ua kom metabolic. Tsis tas li ntawd, ntau saponins cais los ntawm ntau qhov chaw cog tau pom tias tsis muaj peev xwm mutagenic hauv Salmonella / microsome kev soj ntsuam. Ua ke, cov txiaj ntsig no qhia tau tias soapbark extract tsis muaj peev xwm genotoxic.

US FDA: GRASKev txiav txim siab thiab kev tswj hwm lub hauv paus

CovUS Food and Drug Administration (FDA)tau xaivQuillaja bark extractRaws li ib yam khoom uas Feem ntau pom tau tias muaj kev nyab xeeb (GRAS) . 21 CFR 172.510 qhia meej tiasQuillaja Saponaria Extracttuaj yeem siv los ua cov khoom noj khoom haus hauv ntau hom zaub mov. FEMA Tsis Yog. 2973 tau muab tso rau hauv FEMA GRAS Tshaj Tawm Tsis Tau. 3. FDA's EAFUS database teev cov kev cuam tshuam ntawmQuillaja Saponaria Extract hmoovraws li hauv qab no: emulsifier los yog emulsifying ntsev, tsw enhancer, flavoring agent los yog adjuvant, processing aid, propellant, and deg-finishing agent. Tsis tas li ntawd,GRASCov ntawv ceeb toom xa hauv ob qho tib si 2005 thiab 2021 tau txais "tsis muaj kev tawm tsam" cov lus teb los ntawmFDA.

Nws yog ib qho tseem ceeb los hais txog qhov ntawdGRASraws li txoj cai thiab ua ntej- kev tso cai ua lag luam rau cov khoom noj khoom haus ntxiv sawv cev rau ob txoj hauv kev ua raws cai. CovFDAqhia meej tias aGRASkev txiav txim siab tsis tas yuav muaj kev pom zoo ua ntej - khw; Txawm li cas los xij, nws yuav tsum tau lees paub los ntawm cov ntaub ntawv kev nyab xeeb thiab cov kws tshaj lij pom zoo.

EU EFSA: Tso cai raws li E 999 thiab ADI Tsim

Hauv European Union,Quillaja bark extracttau txais kev tso cai raug cai raws li kev tsim khoom noj khoom haus ntxiv E 999. Nyob rau xyoo 2019, Pawg Neeg Saib Xyuas Khoom Noj thiab Khoom Noj Khoom Haus (FAF Panel) ntawm European Food Safety Authority (EFSA) rov- soj ntsuam E 999 thiab tsim kom muaj Kev Tau Txais Txhua Hnub (ADI) ntawm 3 mg saponins ib kg ntawm lub cev hnyav ib hnub. Hauv xyoo 2024,EFSAtau tawm tswv yim ntxiv txog qhov no rov- kev ntsuam xyuas, pom zoo rau kev hloov kho rau EU specifications uas twb muaj lawm -tshwj xeeb, txo cov kev txwv rau txhuas, mercury, thiab arsenic; qhia txog kev txwv siab tshaj plaws rau cadmium thiab calcium oxalate; thiab nthuav tawm cov kev txwv no ntawm saponin hauv paus.

Tsis tas li ntawd, hauv 2023 thiab 2024,EFSAntsuas qhov kev thov txuas ntxiv ntawm kev siv rauQuillaja Saponaria Extract hmoovraws li ib qho emulsifier hauv ob qho tib si khoom noj khoom haus thiab kua zaub. Lub Tuam Txhab tau txiav txim siab tias, yog tias daim ntawv thov tshiab no tau tso cai, qhov tsim ADI yuav tsis pub dhau ib pawg neeg. Qhov kev ntsuam xyuas no ntxiv qhia txog kev nyab xeeb ntawmQuillaja Saponaria Extractthaum siv rau hauv cov tshuaj noj tshuaj.

JECFA: Kev soj ntsuam los ntawm Koom Haum FAO/WHO Cov Kws Tshaj Lij Choj

Lub Koom Haum Koom Tes FAO/WHO Cov Kws Tshaj Lij Tshaj Lij rau Khoom Noj Ntxiv (JECFA) kuj tau ua qhov kev ntsuam xyuas ntawm cov khoom no. Xyoo 2005,JECFAtau tsim ib pab pawg Txais Kev Tau Txais Txhua Hnub (ADI) rau ob hom tshwj xeebQuillaja saponaria extract-Hom 1 thiab Hom 2; Qhov tseem ceeb, tus nqi ADI tsim rau Hom 2 txawv los ntawm qhov kev txiav txim ntawm qhov loj ntawm ADI tsim los ntawmEFSA. Cov neeg siv yuav tsum ua raws li cov kev cai tshwj xeeb uas siv tau rau thaj tsam uas cov khoom tsim los ua lag luam, thiab yuav tsum sab laj cov kev ntsuam xyuas qhov tseeb los ntawm JECFA thiabEFSAkom tau txais cov ntaub ntawv tseeb tshaj plaws.

Health Canada thiab lwm lub koom haum

Health Canada tau suav nrogquillaja saponaria extract hmoovnyob rau hauv nws cov npe tso cai emulsifiers, Gelling Agents, Stabilizers, thiab Thickeners; Tsis tas li ntawd, Food Directorate of Health Canada tau ua tiav cov ncauj lus kom ntxaws txog kev nyab xeeb ntawm cov khoom.

Tsis tas li ntawd, ib tug pharmacopoeial monograph rauQuillaja (xab npum) tau suav nrog hauv British thiab Fabkis Pharmacopoeias, ntxiv rau underscoring nws ib txwm daim ntawv thov thiab raug lees paub nyob rau hauv cov kws tshuaj.

Khoom noj khoom haus thiab dej haus

Hauv kev siv tswv yim, kev siv ntawmQuillaja saponaria bark extractyuav tsum nruj me ntsis ua raws li kev cai txwv. Qhov Kev Pom Zoo Txhua Hnub (ADI) pom zoo los ntawm EFSA yog 3 mg saponins ib kg ntawm lub cev hnyav ib hnub; qhov no yog ib qho tseem ceeb rau kev ntsuas kev nyab xeeb ntawm kev sib kis. Hauv Tebchaws Meskas, GRN 000165 qhia txog qib siab tshaj plaws ntawm 500 mg / kg (nyob rau hauv qhuav- qhov hnyav) hauv cov dej haus concentrates, thaum GRN 000903 tso cai siv qib ntawm 30 txog 185 mg / 100g thoob plaws ntau yam khoom noj.

Tsiaj Pub

Nyob rau hauv cov tsiaj pub tsiaj, Lub Tswv Yim Txog Kev Tshawb Fawb tau muab los ntawm EU FEEDAP Vaj Huam Sib Luag xaus lus tias, raws li cov kev xav tau ntawm kev siv,quillaja saponaria extract hmoovmuaj kev nyab xeeb raws li pub additive rau hom hom phiaj, cov neeg siv khoom, thiab ib puag ncig. Tshwj xeeb, nws pom tau tias muaj kev nyab xeeb rau cov qaib broiler ntawm qib 250 mg / kg ntawm cov khoom noj tiav, nrog rau kev nyab xeeb ntawm 20 (xav tias cov tshuaj ntxiv muaj 3.58% saponins).

Veterinary Vaccine Adjuvants

Nyob rau hauv veterinary tshuaj,tshuaj saponinsnthuav tawm cov khoom immunostimulatory, thiab lawv thawj daim ntawv thov yog raws li tshuaj tiv thaiv adjuvants. Lub adjuvant tivthaiv muaj purifiedQuillaja saponaria extract-ib yam khoom sib xyaw ua ke- feem ntau hu ua "Quil A." Ib koob tshuaj rau txhaj tshuaj muaj 350 mg ntawm saponins. nyuj, yaj, thiab npua feem ntau ua rau pom kev ua siab ntev rau kev txhaj tshuaj subcutaneous ntawm 1 mg ntawm Quil A; Cov kev phiv tshwm sim feem ntau txwv rau cov mos mos- cov ntaub so ntswg o thiab ib ntus nce hauv lub cev kub, ob qho tib si feem ntau daws tsis pub dhau ob hnub. Tsis tas li ntawd, thaum saponins raug tswj hwm los ntawm Immunostimulating Complex (ISCOM), cov haujlwm hemolytic cuam tshuam nrog cov tshuaj tiv thaiv tuaj yeem txo qis.

Txoj Cai Tsav Tsheb: EU txwv tsis pub tshuaj tua kab mob hauv tsiaj pub

Raws li EU cov cai, cov tshuaj tiv thaiv kab mob yuav tsis raug siv rau hauv cov tsiaj txhu los txhawb kev loj hlob lossis nce cov qoob loo; Tsis tas li ntawd, cov tshuaj tiv thaiv kab mob tshwj xeeb rau kev kho mob ntawm tib neeg cov kab mob yuav tsis raug siv los kho tsiaj. Raws li ib tug natural feed additive,quillaja saponaria extract hmoovtau ua kom pom kev ua tau zoo hauv kev tswj cov hnyuv thiab txhim kho kev ua haujlwm ntawm cov nqaij qaib loj hlob, xws li broilers. Yog li ntawd, raws li ib tug natural pub additive pab raws li ib tug lwm txoj rau tshuaj tua kab mob, nws yuav tsum tau muaj ib tug tseem ceeb surge nyob rau hauv kev thov.

Kev Lag Luam Loj thiab Kev Loj Hlob Trends

Kev ua lag luam thoob ntiaj teb rausoapbark extracttuav cov lus cog tseg loj heev, nthuav qhia ntau txoj hauv kev loj hlob thoob plaws ntau qhov chaw, suav nrog zaub mov thiab dej haus, tshuaj, kev saib xyuas tus kheej thiab tshuaj pleev ib ce, thiab tsiaj pub tsiaj. Cov ntsiab lus tseem ceeb uas ua rau kev loj hlob ntawm kev lag luam no suav nrog qhov puas tau - qhov kev thov ntau ntxiv rau cov neeg ua npuas dej, nws daim ntawv thov nthuav dav hauv cov qauv tshuaj pleev ib ce, thiab kev nyiam cov neeg siv khoom loj hlob rau cov nroj tsuag - muab cov khoom xyaw. Hauv cheeb tsam, Tebchaws Europe thiab Tebchaws Meskas yog thawj tus neeg siv khoom lag luam rauQuillaja saponaria extract.

Cov lus qhia yav tom ntej rau R & D

Nyob rau hauv lub neej yav tom ntej, kev tshawb fawb thiab kev loj hlob kev siv zog hais txogOrganic Quillaja saponaria Extractcia siab tias yuav txuas ntxiv mus rau ob qhov loj: kev ua liaj ua teb thiab tshuaj. Hauv kev ua liaj ua teb,quillaja saponaria extract hmoovtuav txoj kev tshawb fawb dav dav hauv thaj chaw ntawm kev tswj cov kab mob fungal thiab kho av; nws lub hauv paus surfactant thiab cov khoom siv tshuaj tua kab mob tiv thaiv ntxiv hauv - kev txhim kho tob. Hauv kev lag luam tshuaj, purified feem ntawmtshuaj saponins-tshwj xeeb yog QS-21-tau tshwm sim los ua cov khoom siv tseem ceeb hauv ntau yam tshuaj tiv thaiv tus nqi siab (xws li cov rau COVID-19, malaria, thiab shingles), nrog rau lawv txoj kev nyab xeeb thiab kev tiv thaiv kab mob tsis tu ncua tau raug lees paub los ntawm tib neeg kev sim tshuaj.

Txhua qhov kev ntsuam xyuas ntawm kev nyab xeeb yog kwv yees raws li kev siv tsim nyog thiab ntau npaum li cas.Quillaja Saponaria Extract hmoovraug suav hais tias muaj kev nyab xeeb thaum siv nyob rau hauv kev tso cai ntau npaum li cas rau kev siv zaub mov thiab tshuaj pleev ib ce; Txawm li cas los xij, kev noj ntau dhau lossis siv cov tshuaj tsis huv tuaj yeem ua rau muaj kev phom sij.Saponaria tawvmuaj ntau ntau tannins thiab oxalates; Kev noj ntau ntau yuav ua rau lub raum thiab lub siab puas tsuaj, nrog rau kev mob plab hnyuv. Yog li ntawd, kev nyab xeeb sivQuillaja Saponaria Extracttso siab tsis tau tsuas yog nyob rau hauv kev ntsuam xyuas tag nrho los ntawm cov kev cai lij choj lub cev tab sis kuj nyob rau hauv lub collective adherence ntawm tag nrho cov tog neeg nyob rau hauv lub mov saw rau tsim kev cai txwv.

Raws li ib tugtsim tawmntawmSaponaria bark extract hmoov, KINTAIBIO^®tseem cog lus los muab peb cov neeg muas zaub nrog cov khoom uas muaj kev nyab xeeb, ua raws, thiab tag nrho traceable. Peb ua tib zoo xaiv premium-zoo rawSaponariacov ntaub ntawv los xyuas kom meej tias qib saponin nyob rau hauv ib qho chaw ruaj khov. Tsis tas li ntawd, peb tswj cov impurities- xws li tshuaj tua kab residues, hnyav hlau, tannins, thiab oxalates- ncaj qha ntawm qhov chaw, yog li lav qhov zoo ib yam ntawm peb cov khoom. Peb siv cov txheej txheem kev rho tawm, ua raws li kev ua kom huv huv thiab ua kom zoo dua qub, kom ntseeg tau tias qhov purity thiab sib xws ntawm cov khoom kawg. Tsis tas li ntawd, peb ua nruj, batch - los ntawm - batch kuaj rau cov hlau hnyav, cov kab mob microbial, thiab physicochemical parameters los xyuas kom meej tias txhua batch ua tau raws li tag nrho cov kev cai. Thov hu rau peb ntawmsales@kintaibio.com.