Lub npe thev naus laus zis: Ib qho khoom siv thev naus laus zis thiab kev npaj ntawm Lappaconitine Hydrobromide
Daim ntawv thov (patent): XI'AN KINTAI BIOTECH INC.
Chaw Nyob: 3rd Floor, Unit 3, Building 16, Zhongnan Hi tech Airport Industrial Port, Airport New City, Xixian New Area, Shaanxi Province, China.
Invention (tsim): Zou Yuchi, Chen Jinfeng, Wang Pan
Patent tswv: XI'AN KINTAI BIOTECH INC.
Abstract:
1. Qhov kev tsim khoom muaj feem xyuam rau ib txoj kev npaj ntawm Lappaconitine Hydrobromide, suav nrog cov kauj ruam hauv qab no:
2. tsoo lub hauv paus ntawm Aconitum sinomontanum, ntxiv rau ethanol hnyav rau immersion thiab percolation;
3. Cov kua permeability hauv lub tshuab nqus tsev 0.050 ~ 0.070 MPa, kub 60 ~ 80 degree thev naus laus zis rau kev tsom xam;
4. Recycling ethanol, tau txais cov cawv muaj zog;
5. Concentrated cawv ntawm qhov kub thiab txias ntawm 20 ~ 60 degree technology, siv acidification tus neeg sawv cev acidification rau pH1 ~ 2, lim, tau acidification kua;
6. Acidification kua nrog alkaline tus neeg sawv cev rau alkalization pH9 ~ 10, tau txais alkaline kua;
7. Alkaline kua thiab chloroform extraction, ntxiv dehydrant dehydration, recycling chloroform, tau txais cov kua extract;
8. Extracting kua ntxiv ethanol stalling, crystallization, ntxuav nrog ethanol, tau txais 93 feem pua Lappaconitine crystallization (kuaj los ntawm acid-base titration);
9. siv cov txheej txheem rau Lappaconitine crystallization los ua hydrobromide, tau txais 96 feem pua -98 feem pua Lappaconitine Hydrobromide (kuaj los ntawm HPLC).
Qhov kev tsim no yog kev siv hluav taws xob tsawg, tsawg impurities, siab purity; Rau loj scale industrial ntau lawm.
