Pharmacological teebmeem ntawm lappaconitine hydrobromide

Gao aconite yog ib hom tshuaj suav tshuaj ntsuab siv los ntawm cov neeg nyob rau sab qaum teb sab hnub poob ntawm Tuam Tshoj rau qhov mob nyem. Lappaconitine (LA), tseem hu ua aconitine thiab aconitine, yog alkaloid rho tawm thiab cais tawm ntawm cov hauv paus hniav ntawm Ranunculaceae cog, aconitine. Nws yog C18 hom diterpenoid, thiab nws daim ntawv thov kev kho mob tseem ceeb Nws yog octoprene hydrobromide. Cov kev tshawb fawb tau pom tias clathrin muaj cov tshuaj ua kom tsis haum, tiv thaiv - mob, detumescent, thiab tshuaj tiv thaiv kab mob, thiab tseem muaj qhov zoo ntawm kev tsis yog - kev quav tshuaj thiab cov tshuaj tiv thaiv tsis zoo.

Lappaconitine Hydrobromideyog hydrobromide monohydrate ntawm laba aconitine muab rho tawm los ntawm cov hauv paus hniav ntawm Ranunculaceae nroj tsuag, thiab nws yog thawj zaug uas tsis yog - qaug zog hauv nruab nrab paj hlwb hauv Suav teb. Cov tshuaj analgesic tshiab yog ib qho tshuaj tua kab mob me me uas tau sau tseg hauv "Cov Cai Qhia Txog Peb -theem Pain Relief Therapy for Cancer Patients" los ntawm Ministry of Health. Nws qhov kev siv tshuaj loog yog 7 npaug ntawm aminopyrine, uas yog sib npaug rau cov nyhuv analgesic ntawm pethidine, tsis muaj cov teebmeem teratogenic thiab mutagenic, thiab muaj cov tshuaj loog hauv zos, cua txias thiab tshuaj tua kab mob, thiab tseem ceeb tiv thaiv - inflammatory thiab detumescent teebmeem.Lappaconitine Hydrobromide HBrmuaj cov nyhuv analgesic los ntawm kev sib txawv ntawm kev tswj hwm.

Qhov pib ntawm kev txiav txim qeeb qeeb dua li ntawm pethidine, thiab lub sijhawm ntawm kev ua xua yog ntev dua li pethidine. Nws tsis muaj kev vam khom, tsis muaj teebmeem teratogenic, thiab tsis muaj teebmeem teratogenic. Tshuaj lom yuav sib sau. Tsis tas li ntawd, nws kuj muaj cov haujlwm ntawm cov tshuaj loog hauv zos, txias, antipyretic thiab detumescence. Qee tus neeg mob qog nqaij hlav tuaj yeem txhim kho cov kab mob hauv lub cev thaum lub sijhawm thov, xws li kev noj qab haus huv ntxiv, txhim kho tus ntsuj plig, txhim kho kev tiv thaiv kab mob, thiab hloov cov duab ntshav.

Cov nyhuv analgesic

Lappaconitine Hydrobromideyog ib yam uas tsis yog- yeeb tshuaj, tsis yog - opioid analgesic pioneered nyob rau hauv kuv lub teb chaws, thiab tau raug teev raws li "peb-kauj ruam" tshuaj analgesic rau cov neeg mob qog noj ntshav hauv Suav teb. Cov nyhuv analgesic ntawm LA tsis zoo li ntawm morphine, tab sis sib npaug ntawm pethidine, thiab 7 npaug ntawm cov tshuaj tua kab mob analgesic aminopyrine. LA muaj qhov pib qeeb ntawm kev ua xua tab sis ntev ntev ntawm kev ua tau zoo, thiab yog ib qho kev siv ntau dua rau tramadol.

Cov kev tshawb fawb tau pom tiasAconite hauv paus Aconitum Kusnezoffii Extracttuaj yeem cuam tshuam cov kab mob ectopic uas tshwm sim los ntawm kev raug mob axonal los ntawm kev cuam tshuam rau qhov hluav taws xob- nyob ntawm sodium thiab calcium ion channels hauv nruab nrab paj hlwb, thiab ua lub luag haujlwm hauv kev thaiv cov paj hlwb; los ntawm inhibiting lub presynaptic daim nyias nyias ntawm norepinephrine Lub reuptake ntawm serotonin thiab serotonin tsub kom cov ntsiab lus ntawm ob nyob rau hauv lub synaptic cleft, yog li inhibiting tso cov tshuaj P thiab somatostatin nyob rau hauv afferent paj fibers, thiab exerting ib tug muaj zog thiab kav ntev analgesic nyhuv; nws tuaj yeem inhibit qhov periaqueductal grey teeb meem ntawm lub hlwb. thiab calcium influx ntawm cortical hlwb thiab kev qhia ntawm nuclear factor κB, ua si analgesic nyhuv.

Cov tshuaj loog hauv zos-zoo li cov nyhuv

Thaum twgAconite hauv paus Aconitum Kusnezoffii Extractyog txhaj rau hauv qhov chaw epidural, nws ua ncaj qha rau ntawm cov hlab ntsha hauv cov hauv paus hniav, thaiv qhov tsis muaj zog stimulation los ntawm ntu phais. Nws nkag mus rau hauv qhov chaw subarachnoid thiab tuaj yeem ua rau "morphine-zoo li receptors" los pib cov txheej txheem neurohumoral analgesic. Tsis tas li ntawd, nws tuaj yeem nkag mus ncaj qha rau hauv cov ntshav ncig los ntawm venous plexus hauv qhov chaw epidural. Cov tshuaj loog hauv zos cov nyhuv ntawm 0.1%Lappaconitine Hydrobromideyog sib npaug rau cov nyhuv ntawm 0.84% ​​cocaine, thiab cov conduction thaiv cov nyhuv ntawm cov hlab ntsha sciatic hauv nas yog 5.25 thiab 13 npaug ntawm cov yeeb yaj kiab thiab procaine, feem; rau cov nyhuv analgesic ntawm infiltration tshuaj loog Stronger dua cocaine thiab procaine.

Los tiv thaiv - cov teebmeem inflammatory thiab deumescent

Lappaconitine Hydrobromidemuaj cov teebmeem inhibitory ntawm qhov nce capillary permeability, exudation, thiab o tshwm sim los ntawm ntau yam inflammatory qauv, xws li tshem tawm o ntawm auricles, ntiv taw, pob qij txha, thiab qis qis, thiab inhibiting tsim ntawm intrabulbar buds. Cov tshuaj tiv thaiv -cov nyhuv ntawm kev txhaj tshuaj subcutaneous ntawm LA 1.5 mg / kg yog 66 npaug ntawm cov tshuaj aspirin. Kev txhaj tshuaj Intraperitoneal ntawm LA 4 mg / kg tau pom muaj kev tiv thaiv - inflammatory thiab detumescent nyhuv sib npaug rau 50 mg / kg aminopyrine.

Antipyretic nyhuv

Lappaconitine HydrobromideFeem ntau nce cov ntsiab lus ntawm norepinephrine nyob rau hauv lub synaptic cleft los ntawm thaiv cov sodium ion raws, inhibiting paj hlwb conduction thiab reuptake ntawm norepinephrine los ntawm lub presynaptic daim nyias nyias, yog li inhibiting qhov tso tawm ntawm cov tshuaj P, uas muaj peev xwm tsub kom lub thermogenic chaw, thiab exert nws cov nyhuv. Antipyretic nyhuv.

Antiarrhythmic nyhuv

Cov kev tshawb fawb tau pom tias tsawg - koobAconite hauv paus Aconitum Kusnezoffii Extractmuaj kev tiv thaiv -arrhythmic teebmeem, thaum siab - siv koob tshuaj tuaj yeem ua rau arrhythmia. Nws cov txheej txheem ntawm kev ua: los ntawm kev tswj cov kev qhia ntawm qhov hluav taws xob- nyob ntawm sodium / potassium ion channels thiab cov noob protein muaj feem xyuam rau ntawm cov channel, txo qis myocardial contractility, nce myocardial excitation pib, qeeb lossis nres lub plawv dhia; ncaj qha los yog indirectly inhibiting lub depolarization ntawm myocardial hlwb, kom txo tau lub excitability ntawm lub plawv conduction system los tua arrhythmias.

Cov teebmeem ntawm kev tiv thaiv thiab kev ntxhov siab

Lappaconitine HydrobromideTsis tsuas yog txhawb kev loj hlob ntawm cov hlwb reticuloendothelial, tab sis kuj txhim kho lub peev xwm phagocytic ntawm leukocytes thiab mononuclear macrophages. Nws tseem tuaj yeem ua rau tus neeg mob qab los noj mov, txhim kho tus ntsuj plig, thiab txhim kho kev tiv thaiv kab mob ntawm lub cev; ntxiv rau,Aconite hauv paus Aconitum Kusnezoffii Extractmuaj kev tswj xyuas cov txiaj ntsig ntawm ob leeg cellular thiab humoral tiv thaiv, thiab thaum kawg ua lub luag haujlwm hauv kev txhim kho lub cev tiv thaiv kab mob thiab txhim kho kev tiv thaiv kab mob. Lappaconitine Hydrobromide kuj tseem inhibits cov lus teb kev ntxhov siab los ntawm kev txo cov kev mob siab rau kev ua siab ntev thiab ua kom muaj kev sib haum xeeb -adrenal axis kev ua haujlwm.