Icariinyog ib qho bioactive compound muab rho tawm los ntawm ntau hom tshuaj suav tshuaj, tshwj xeeb tshaj yog Horny tshis Weed (Epimedium spp.). Raws li lub ntuj phytochemical los ntawm tsev neeg flavonoid, icariin tau dhau los ua cov tshuaj ntsuab nrov ntxiv vim muaj kev txaus siab rau kev tshawb fawb hauv nws cov khoom siv kho mob dav dav thiab cov teebmeem kev noj qab haus huv. Cov kws tshawb fawb tau txheeb xyuas cov txiaj ntsig bioactivities ntawm icariin suav nrog kev ua haujlwm ntawm kev sib deev, kev loj hlob ntawm pob txha, kev noj qab haus huv ntawm lub plawv, kev tiv thaiv kab mob, thiab kev tiv thaiv kab mob ntawm lwm tus. Tab sis dab tsi tshwj xeeb no intriguing molecule ua nyob rau hauv tib neeg lub cev? Yuav ua li cas thiaj ua tau cov txiaj ntsig zoo li multi-modal physiological? Kab lus no yuav tshawb txog icariin lub hauv paus chiv keeb hauv cov nroj tsuag thaum ub, cov txheej txheem ntawm kev ua haujlwm, cov kev tshawb fawb tseem ceeb, cov ntaub ntawv kev nyab xeeb, thiab cov peev xwm rau tus kheej cov tshuaj.
Keeb kwm thiab ib txwm siv
Icariin cov peev txheej ntuj, Epimedium spp. perennial nroj tsuag, muaj keeb kwm dav dav ntawm kev siv tshuaj hauv Suav teb, Nyiv, thiab lwm qhov chaw ntawm Asia. Kuj tseem hu ua Yin Yang Huo los yog Horny tshis Weed, ntau hom Epimedium loj hlob ntawm qhov siab siab thoob plaws sab hnub tuaj Asia thiab tau ua kev kho mob pej xeem rau ntau pua xyoo. Cov ntawv Suav thaum ub hais txog cov tshuaj ntsuab no thaum ntxov li 400 AD rau kev txhawb nqa kev ua menyuam yaus thiab rov ua kom cov hluas muaj zog. Cov nroj tsuag kuj tau txais cov yeeb yuj lub npe uas tshwm sim los ntawm cov dab neeg ntawm tshis grazing ntawm Epimedium nthuav tawm randy, tus cwj pwm kev sib deev. Cov tshuaj suav tshuaj (TCM) cov lus qhuab qhia categorizes cov tshuaj ntsuab raws li lub raum thiab yang tonic. Cov kws kho mob tau sau tseg ntev Epimedium extracts raws li ntuj aphrodisiacs los txhawb libido, ameliorate impotence thiab txhim kho fertility, muaj peev xwm ua me nyuam thiab hnov. Tshaj li kev siv kev sib deev, TCM tau siv cov botanicals no los txhawb cov pob txha thiab pob qij txha, txhawb kev ncig, thiab txhawb kev tiv thaiv kab mob los yog kab mob. Niaj hnub nimno analytical txoj kev tam sim no tau txheeb xyuas qhov kos npe flavonoid constituents, tshwj xeeb tshaj yog icariin, uas yog thawj bioactives imparting cov khoom kho mob.
Cov tshuaj ntsuab twg muaj Icariin?
Txawm hais tias ntau yam tshuaj ntsuab hauv tsev neeg Berberidaceae tau kuaj pom zoo rau icariin, cov nroj tsuag hauv Epimedium genus tseem yog cov khoom lag luam zoo tshaj plaws thiab muaj txiaj ntsig zoo. Hom kab mob xws li Epimedium sagittatum, E. brevicornum thiab E. koreanum muaj qhov tshwj xeeb siab txog li 2% ntawm tag nrho qhov hnyav qhuav. Cov khoom siv dav hlau (nplooj, stems, paj) ua cov khoom tseem ceeb rau kev rho tawm icariin. Siv cov txheej txheem chromatographic fractionation, cov tuam txhab tam sim no tuaj yeem tsim cov tshuaj icariin purified nrog rau cov txheej txheem Epimedium extracts lav kom muaj feem pua ntawm cov hom phiaj molecule. Dhau li Epimedium spp., lwm hom icariin-cov kabmob muaj xws li Achyranthes bidentata (Niu Xi), Caulophyllum robustum (xiav cohosh) thiab qee yam Clematis vines. Tab sis cov tshuaj Epimedium tam sim no tswj hwm thoob ntiaj teb cov khoom ntawm cov flavonoid tshwj xeeb no.
Cov teebmeem ntawm Icariin yog dab tsi?
Kev ntsuam xyuas cov teebmeem ntawm icariin qhia tias nws koom nrog ntau txoj hauv kev lom neeg txuas nrog kev sib deev kev noj qab haus huv, vascular muaj nuj nqi, kev tswj hwm cov tshuaj hormones, kev puas siab puas ntsws thiab lub neej ntev. Nov yog cov ntsiab lus ntawm kev tshawb fawb-txhawb bioactivities:
- Aphrodisiac Qualities - Txhawb kev muaj siab thiab kev ua tau zoo ntawm cov txiv neej thiab poj niam los ntawm kev txhawb nqa nitric oxide thiab dilating cov hlab ntsha kom txhawb kev ncig mus rau qhov chaw mos.
- Kev yug me nyuam - tswj kev ua haujlwm ntawm poj niam txiv neej, txhawb cov phev ntau lawm, kev loj hlob ntawm follicle thiab fertility biomarkers nyob rau hauv ob qho tib si poj niam txiv neej.
- Kev Tiv Thaiv Pob Txha - Txhawb kev loj hlob ntawm osteoblast pob txha hlwb thiab mineralization thaum suppressing pob txha resorption los ntawm osteoclasts kom pob txha ceev. Ua rau osteoporosis qeeb.
- Cognitive Boost - Stimulates neuronal kev loj hlob yam tseem ceeb BDNF thiab NGF los txhawb lub hlwb cell noj qab haus huv thaum pab txhawb kev mloog, kev kawm thiab nco consolidation.
- Cardiovascular Aid - Relaxes arteries, txo cov platelet aggregation peev xwm thiab exerts ib tug array ntawm kev tiv thaiv rau lub plawv thiab circulatory noj qab haus huv.
Mechanisms ntawm Action
Kev tshawb fawb Pharmacological txheeb xyuas ntau txoj hauv kev lom neeg uas hloov kho los ntawm icariin kom tshem tawm nws cov teebmeem kev kho mob. Ob txoj haujlwm tseem ceeb suav nrog:
• Inhibiting PDE5 enzyme-raws li pom nrog erectile kawg cov tshuaj-ua rau nce cGMP theem uas ua rau vasodilatory nitric oxide ntau lawm thiab qhov chaw mos cov ntshav khiav.
• Ua kom muaj kev qhia ntawm nitric oxide synthase noob ntxiv nce NO qib txhawb kev sib deev arousal.
Tsis tas li ntawd, icariin zoo nkaus li ua kom muaj zog testosterone ua haujlwm hauv cov hlwb los ntawm kev nthuav qhia ntawm androgen receptors hauv cov ntaub so ntswg thiab cov neural network tswj kev ua haujlwm ntawm kev sib deev. Qhov no testosterone mimetic nyhuv pab piav qhia nws cov tshuaj aphrodisiac ib txwm muaj. Kev txhawb nqa pob txha loj hlob los ntawm kev ua kom muaj kev sib txawv thiab kev loj hlob ntawm osteoblasts, ua kom cov collagen biosynthesis thiab txhawb nqa biomarker proteins zoo li RUNX2 txuas rau pob txha tsim thiab mineralization. Neuroprotective teebmeem tshwm sim los ntawm kev ua antioxidant thiab kev loj hlob ntawm cov khoom txhawb nqa kev noj qab haus huv neuronal thiab teeb liab. Ntau theem kev tiv thaiv kab mob kuj tseem pom tau zoo hauv ntau yam ntawm icariin cov dej num lom neeg.
Kev Tshawb Fawb thiab Kev Tshawb Fawb Txog Kev Tshawb Fawb
Kev tshawb nrhiav kev tshawb fawb muaj zog nyob rau kaum xyoo dhau los tseem txuas ntxiv kev siv cov kev siv ib txwm siv ntawm icariin thaum tseem nthuav tawm nws cov ntawv thov tshiab. Ob qhov muag tsis pom RCTs lees paub icariin qhov ua tau zoo thiab kev nyab xeeb rau kev txhim kho erectile muaj nuj nqi thiab kev noj qab haus huv ntawm kev sib deev. Ib qho kev soj ntsuam ntawm 17 txoj hauv kev nrog ntau dua 1500 cov ntsiab lus pom cov txiaj ntsig zoo sib xws rau arousal, erectile peev, orgasm, thiab kev sib deev txaus siab piv rau cov pab pawg placebo. Cov kws tshawb nrhiav kuj tseem ceeb rau cov teeb meem epariin nce pob txha thiab boosted bolrix calcification hauv kev coj noj coj ua. Kev tshawb fawb txog paj hlwb qhia icariin tiv thaiv amyloid beta plaque tsim txuas rau Alzheimer's kab mob thiab ua rau muaj kev cuam tshuam zoo li kev nyuaj siab piv rau cov tshuaj SSRI hauv cov qauv tsiaj. Kev tshawb nrhiav tsis tu ncua txuas ntxiv mus rau hauv cov tshuaj tiv thaiv neoplastic tiv thaiv prostate, zes qe menyuam, ntsws thiab lwm yam kab mob phenotypes. Lub compound tseem tuav cov lus cog tseg raws li cardioprotective, tiv thaiv kab mob thiab metabolic-regulating tus neeg sawv cev. Hauv qhov chaw tshuaj sib xyaw ua ke, kev kho tus kheej icariin qhia tau hais tias muaj peev xwm ua tau raws li daim ntawv thov ntawm tus neeg mob keeb kwm thiab kev pheej hmoo.
Puas yog Icariin nce Testosterone?
Txawm hais tias qee qhov kev lees paub tias icariin ncaj qha nce qib testosterone synthesis, cov pov thawj tam sim no zoo dua txhawb nqa nws ua haujlwm ntawm testosterone mimetic lossis sensitizer ntawm qib intracellular. Icariin zoo nkaus li ua kom pom kev ua haujlwm zoo ib zaug testosterone khi rau androgen receptors thaum kawg txhawb kev ua haujlwm ntawm qhov tseem ceeb tshaj plaws masculinizing hormone. Nws kuj tseem txhawb nqa cyclic GMP signaling twb tau txhawb los ntawm testosterone kev ua haujlwm ntxiv txhim kho nws cov teebmeem virilizing ntawm lub cev thiab lub hlwb. Yog li rau cov tib neeg uas tsis tshua muaj testosterone uas qhia cov tsos mob hypogonadic, icariin tuaj yeem muab cov tswv yim botanical rau amplifying lackluster testosterone yam tsis tas yuav nce net ntau lawm. Nco ntsoov sab laj tus kws kho mob txhawm rau txheeb xyuas qhov tsim nyog icariin koob tshuaj thiab saib xyuas qhov sib npaug ntawm cov tshuaj hormones.
Kev nyab xeeb thiab kev phiv
Cov ntaub ntawv tam sim no qhia tias icariin ua rau muaj kev phom sij tsawg tsawg nrog qee qhov kev phiv tshwm sim tau tshaj tawm txawm tias ntau dua (txog 200mg / hnub). Raws li cov flavonoids mus, icariin qhia tau hais tias bioavailability zoo heev thiab qhov ncauj nqus tau mus txog qib ntshav plasma hauv 1 teev tom qab noj. Kev mob plab me me lossis raws plab tau tshwm sim qee zaus tab sis sai sai thaum txiav tawm. Txawm li cas los xij, cov neeg siv tshuaj tiv thaiv coagulant lossis cov tshuaj tiv thaiv platelet yuav tsum zam kom tsis txhob muaj icariin supplementation vim muaj kev txhawj xeeb txog kev muaj peev xwm los ntshav txaus txawm tias tsis muaj kev cuam tshuam los ntawm kev kho mob tam sim no. Raws li qhov xav tau, cov neeg laus, cov menyuam yaus, cov poj niam cev xeeb tub lossis cov neeg muaj kev tiv thaiv kab mob yuav tsum tsis txhob noj icariin yam tsis muaj kev saib xyuas zoo. Kev tshuaj xyuas ua ntej los ntawm tus kws kho mob lossis kws kho mob tso cai rau tus kheej ntawm kev noj tshuaj thiab txo qis kev pheej hmoo. Feem ntau icariin qhia tau hais tias muaj kev nyab xeeb zoo nrog cov txiaj ntsig zoo-rau-kev pheej hmoo.
Xaus
Qhov tshwj xeeb flavonoid icariin cog lus tias muaj peev xwm kho tau zoo li lub cuab yeej hloov kho rau kev txhawb nqa kev sib deev kev noj qab haus huv, kev loj hlob, muaj peev xwm ua me nyuam, kev ua haujlwm ntawm lub paj hlwb thiab kev noj qab haus huv laus raws li ntau txhiab xyoo ntawm pej xeem siv tam sim no txhawb nqa los ntawm kev tshawb fawb niaj hnub. Kev tshawb nrhiav tus kheej icariin kev tswj hwm raws li kev taw qhia kev tshaj lij tuaj yeem muab kev nyab xeeb, kev txhawb nqa cog qoob loo tsim nyog rau ib qho kev noj qab haus huv tseem ceeb txawm hais tias lub hauv paus ntawm kev sib deev, kev txuag pob txha los yog dhau mus. Raws li kev tshawb fawb txuas ntxiv unraveling nws multi-modal bioactivities, diluted cov ntaub ntawv ntawm no lub hom phiaj Horny tshis Weed phytochemical tej zaum yuav nws thiaj li nrhiav tau daim ntawv thov raws li ntuj hloov rau tej yam tshuaj cuam tshuam. Muab nws lub hauv paus chiv keeb hauv TCM, icariin kho tau zoo kawg nkaus nrog cov tshuaj kho mob ib txwm muaj raws li niaj hnub biomedicine.
PebIcariin hmoovtau txais kev qhuas zoo los ntawm cov neeg siv khoom. Yog tias koj xav paub ntau ntxiv txog cov khoom no, thov hu rau dawbSales@Kintaibio.Com.
Cov ntaub ntawv:
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