Matrineyog ib txwm tshwm sim alkaloid compound nrog ntau yam kev ua haujlwm lom neeg. Nws yog ib qho tetracyclo-quinolizine alkaloid pom feem ntau hauv ntau hom nroj tsuag uas yog Sophora genus. Matrine tau txais txiaj ntsig zoo vim nws cov kev siv tshuaj kho tau zoo hauv cov tshuaj suav tshuaj (TCM) thiab kev tshawb fawb tshuaj niaj hnub.
Matrine muaj ob peb yam tshuaj, suav nrog kev txo qis, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab kev cuam tshuam immunomodulatory. Cov khoom no tau ua matrine ib qho kev kawm ntawm kev tshawb fawb dav hauv cov tshuaj, kws tshuaj, thiab cov khoom siv tshuaj lom neeg.
Botanical Qhov Chaw ntawm Matrine
Matrine muaj nws lub hauv paus hauv cov tshuaj suav tshuaj (TCM), qhov twg nws tau siv sijhawm ntev los kho cov kab mob sib txawv. Thawj qhov chaw botanical ntawm matrine yog cov nroj tsuag hom Sophora flavescens (Kushen) thiab Sophora subprostrata (Shandougen).
- Sophora flavescens (Kushen)
Sophora flavescens, ib txwm hu ua Kushen, yog ib tsob ntoo hauv zos rau Tuam Tshoj, Kaus Lim Kauslim, thiab Nyiv. Nws tau siv dav hauv TCM rau nws cov tshuaj tua kab mob, txo qhov mob, thiab txo cov khoom.
Kushen yog qhov chaw nplua nuj ntawmmatrine, muaj txog li 1% ntawm alkaloid hauv nws cov hauv paus hniav.
- Sophora subprostrata (Shandougen)
Sophora subprostrata, tseem hu ua Shandougen, yog lwm hom nroj tsuag uas muaj qib siab ntawm matrine. Nws yog cov txuj lom uas kav ntev tau taug qab nyob rau hauv ntau lub zos ntawm Tuam Tshoj, tshwj xeeb tshaj yog nyob rau sab qaum teb thiab sab qaum teb thaj tsam.
Geographical Distribution thiab Cultivation
Hom Sophora nplua nuj nyob rau hauv matrine feem ntau pom nyob rau sab hnub tuaj Asia, suav nrog Tuam Tshoj, Kauslim Teb, thiab Nyiv. Cov nroj tsuag no tau cog qoob loo rau ntau pua xyoo vim lawv cov nqi tshuaj hauv TCM. Nyob rau hauv xyoo tas los no, kev lag luam cog qoob loo ntawm Sophora hom tau nthuav dav kom ua tau raws li qhov kev thov loj hlob rau matrine thiab nws cov khoom tau los.
Chemical Composition ntawm Matrine
Matrine yog ib tus neeg los ntawm tsev neeg alkaloid, uas muaj nitrogen-muaj cov khoom sib xyaw ua ke hauv cov nroj tsuag sib txawv. Nws yog thawj active ingredient lub luag hauj lwm rau lub pharmacological kev ua ub no ntawm Sophora hom.
- Alkaloids hauv Matrine
Matrine yog ib qho tetracyclo-quinolizine alkaloid, uas txhais tau hais tias nws muaj ib lub nplhaib complex uas muaj plaub fused rings thiab quinolizine moiety. Ntxiv nrog rau matrine, lwm cov alkaloids xws li oxymatrine, sophocarpine, thiab oxysophocarpine kuj muaj nyob hauv hom Sophora.
- Cov yam ntxwv zoo thiab cov qauv molecular
Matrine hmoovCov mis mos molecular C15H24N2O thiab molecular hnyav 248.37 g/mol. Nws cov qauv tshuaj muaj xws li ob lub nplhaib fused, lub nplhaib quinolizine, thiab lub nplhaib piperidine, nrog rau ntau yam hloov pauv txuas rau lub nplhaib.
- Pharmacological Activities thiab muaj peev xwm pab tau
Matrine tau kawm dav dav rau nws cov kev siv tshuaj kho mob. Nws nthuav tawm ntau yam kev ua haujlwm tshuaj, suav nrog tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, immunomodulatory, tiv thaiv kab mob plawv, thiab cov teebmeem neuroprotective. Cov khoom no ua rau matrine yog ib tus neeg sib tw zoo rau kev txhim kho cov tshuaj tshiab thiab cov kev pabcuam kho mob.
Extraction thiab ntau lawm txoj kev
Txhawm rau kom tau txais matrine los ntawm nws cov khoom siv botanical, ntau yam kev rho tawm tau ua haujlwm, xws li los ntawm cov txheej txheem ib txwm siv mus rau cov txheej txheem kev lag luam niaj hnub.
- Tsob Ntoo Extraction Techniques
Hauv cov tshuaj suav tshuaj, matrine tau muab rho tawm los ntawm Sophora hom siv dej-raws li decoctions lossis infusions. Cov hau kev no cuam tshuam nrog boiling los yog steeping cov khoom cog hauv dej kom rho tawm cov khoom xav tau.
- Niaj hnub nimno Extraction Method
1. Cov kuab tshuaj Extraction
Niaj hnub nimno extraction txoj kev raumatrinefeem ntau koom nrog kev siv cov kuab tshuaj organic, xws li methanol, ethanol, los yog sib xyaw ntawm cov kuab tshuaj. Cov kuab tshuaj no muaj peev xwm ntawm kev rho tawm matrine thiab lwm yam alkaloids los ntawm cov khoom cog zoo dua li cov txheej txheem dej.
2. Supercritical Fluid Extraction
Supercritical fluid extraction (SFE) yog cov txheej txheem siab heev uas siv cov kua dej supercritical, xws li cov pa roj carbon dioxide, kom rho tawm matrine los ntawm cov khoom cog. Txoj kev no yog suav tias yog ib puag ncig tus phooj ywg thiab tuaj yeem ua tiav cov txiaj ntsig siab extraction nrog cov kuab tshuaj tsawg tsawg.
- Muaj ntau lawm thiab ua lag luam muaj
Nrog rau kev xav tau ntau ntxiv rau matrine thiab nws cov khoom siv, ntau lub tuam txhab tau tsim cov chaw tsim khoom lag luam. Cov chaw no siv cov txheej txheem niaj hnub rho tawm thiab ua kom huv huv kom tau txais matrine los ntawm Sophora hom nyob rau hauv tus nqi-zoo thiab ruaj khov. Matrine thiab nws cov tshuaj muaj feem xyuam yog muag rau kev tshawb fawb thiab kev siv tshuaj.
Kev kho mob thiab kho mob siv Matrine
- Ib txwm siv hauv TCM
Matrine tau siv rau hauv cov tshuaj suav tshuaj rau ntau pua xyoo los kho ntau yam mob, suav nrog kub taub hau, mob, arrhythmia. Nws tau raug suav hais tias yog tshuaj ntsuab muaj txiaj ntsig hauv TCM vim nws qhov dav ntawm cov khoom kho mob.
- Immunomodulatory Effects thiab Anti-inflammatory Activity
Ib qho tseem ceeb tshaj plaws pharmacological kev ua ub no ntawm matrine yog nws lub peev xwm los hloov kho lub cev tiv thaiv kab mob thiab muaj cov tshuaj tiv thaiv kab mob.Matrine hmoovtau pom tias inhibit zus tau tej cov inflammatory mediators, xws li cytokines thiab prostaglandins, ua rau nws muaj peev xwm kho tau tus kab mob inflammatory.
Matrine kuj tau ua kom pom cov cuab yeej immunomodulatory, txhim kho lossis tiv thaiv lub cev tiv thaiv kab mob nyob ntawm qhov tshwj xeeb. Cov khoom no tau coj mus rau kev tshawb fawb txog kev siv cov matrine hauv kev kho mob autoimmune, kev kis kab mob.
Kev nyab xeeb, kev phiv, thiab kev ceev faj
- Toxicity Studies thiab Safety Profile
Thaum matrine feem ntau suav hais tias muaj kev nyab xeeb rau kev siv, nws cov ntaub ntawv kev nyab xeeb tau raug kawm ntau. Cov kev tshawb fawb tsiaj tau pom tias matrine muaj cov tshuaj toxicity tsawg thaum noj cov tshuaj uas tsim nyog. Txawm li cas los xij, kev siv tshuaj ntau lossis siv ntev yuav ua rau muaj kev phiv.
- Muaj peev xwm cuam tshuam nrog cov tshuaj
Matrine tuaj yeem cuam tshuam nrog qee yam tshuaj, tshwj xeeb yog cov metabolized los ntawm cytochrome P450 enzyme system. Nws yog ib qho tseem ceeb uas yuav tau sab laj nrog tus kws kho mob ua ntej noj matrine, tshwj xeeb tshaj yog tias koj noj lwm yam tshuaj los yog muaj mob hauv qab no.
- Pom zoo noj thiab ceev faj
Qhov pom zoo noj ntawmmatrineNws txawv nyob ntawm seb tus mob twg raug kho thiab cov qauv siv. Feem ntau, nws raug nquahu kom ua raws li cov lus qhia ntau npaum li cas los ntawm cov kws kho mob lossis cov chaw muaj npe nrov. Cov poj niam cev xeeb tub thiab pub niam mis yuav tsum tau ceev faj thiab sab laj nrog lawv cov kws kho mob ua ntej siv cov khoom siv matrine.
Xaus
Matrine yog ib qho khoom muaj txiaj ntsig zoo nrog ntau yam kev ua haujlwm tshuaj thiab kho lub peev xwm. Nws cov peev txheej botanical, feem ntau yog hom Sophora, tau siv hauv cov tshuaj suav tshuaj rau ntau pua xyoo. Los ntawm niaj hnub rho tawm thiab ntau lawm txoj kev, matrine tau dhau los ua kom yooj yim rau kev tshawb fawb thiab kev siv tshuaj muaj peev xwm.
Thaum matrine tuav cov lus cog tseg hauv ntau qhov chaw kho mob, xws li mob, kho immunomodulation, kev tshawb fawb ntxiv yog tsim nyog kom nkag siab tag nrho nws cov txheej txheem ntawm kev ua, kev nyab xeeb profile, thiab cov tshuaj muaj peev xwm sib cuam tshuam. Kev tshawb nrhiav txuas ntxiv ntawm matrine thiab nws cov derivatives tuaj yeem ua rau kev txhim kho cov tshuaj kho tshiab thiab pab txhawb kev nce qib ntawm cov tshuaj suav tshuaj hauv kev kho mob niaj hnub no.
Txais tos xa email rau peb yog tias koj txaus siab rauMatrine hmoovNtawmSales@Kintaibio.Com.
Cov ntaub ntawv:
1. Guo, B., Kai, G., & Jin, H. (2021). Matrine: Kev tshuaj xyuas dav dav ntawm nws cov haujlwm tshuaj thiab cov txheej txheem. Biomedicine & Pharmacotherapy, 141, 111899.
2. Wang, C., Zhang, D., Ma, H., & Liu, J. (2017). Membrane rov qab demulsification ntawm matrine los ntawm ethanol extract ntawm Sophora flavescens Ait los ntawm ob theem demulsification. Separation and Purification Technology, 175, 326-334.
3. Yin, X., Gao, L., Liu, K., Lu, C., & Zhai, G. (2021). Matrine thiab nws cov derivatives: Kev hloov kho cov qauv thiab lawv cov kev siv tau. European Journal of Medicinal Chemistry, 215, 113254.
4. Xu, G., Zhao, X., Fu, J., Zhou, S., Li, J., & Zhou, L. (2017). Matrine: Kev tshuaj xyuas ntawm nws cov haujlwm pharmacological thiab pharmacokinetics. Yav tom ntej Medicinal Chemistry, 9(8), 895-913.
5. Guo, B., Kai, G., Jin, H., & Tang, K. (2021). Matrine: Ib qho kev piav qhia ntawm nws cov haujlwm pharmacological thiab cov peev txheej. Phau ntawv Journal of Ethnopharmacology, 268, 113634.
6. Liao, P., Luo, L., Xiao, W., Zeng, J., & Wei, X. (2020). Matrine: Kev tshuaj xyuas ntawm nws cov kev ua haujlwm pharmacological thiab cov ntawv thov muaj peev xwm hauv cov tshuaj niaj hnub. Suav Tshuaj, 15(1), 1-14.
7. Li, W., Fan, T., Zhang, Y., Zhang, Y., & Zhang, W. (2019). Matrine-type alkaloids thiab lawv cov kev ua haujlwm pharmacological. Frontiers hauv Chemistry, 7, 499.
8. Qiu, Y., Zheng, Y., Jiang, W., & Ouyang, X. (2020). Kev nce qib hauv kev rho tawm ntawm matrine thiab nws cov analogues ntawm Sophora flavescens. Tam sim no Pharmaceutical Analysis, 16(5), 568-579.
