Part1. Dab tsi yogGlabridin hmoov?
Glabridin yog flavonoid, muab rho tawm los ntawm cov nroj tsuag muaj txiaj ntsig hu ua licorice glabra. Glabridin yog lub npe hu ua "whitening gold" vim nws cov nyhuv whitening muaj zog, uas tuaj yeem tshem tawm cov dawb radicals thiab melanin hauv daim tawv nqaij. Nws yog daim tawv nqaij whitening thiab anti-aging dawb huv yam.
Ntu 2. Lub ntsiab mechanism ntawm kev txiav txim ntawm glabridin inhibit melanin yog raws li
raws li nram no:
1. Inhibition ntawm tyrosinase
Tib neeg tyrosinase yog ib qho tseem ceeb enzyme, uas tuaj yeem tsim melanin tsis tu ncua thiab tig daim tawv nqaij lossis ob lub qhov muag los ntawm xim av mus rau dub. Peb paub tias qhov raug ntawm daim tawv nqaij rau lub teeb ultraviolet tuaj yeem ua rau qee qhov kev tshwm sim (xws li mob). Txij li thaum phospholipid daim nyias nyias ntawm daim tawv nqaij puas lawm los ntawm reactive oxygen hom induced los ntawm ultraviolet lub teeb, qhov kev hloov histological yog manifested li erythema thiab hyperpigmentation. Active oxygen yog ib yam khoom uas tuaj yeem ua rau cov tawv nqaij pigmentation, yog li inhibiting nws cov khoom tuaj yeem inhibit zus tau tej cov melanin. Glabridin yog qhov kim tshaj plaws thiab muaj txiaj ntsig zoo ntawm cov khoom xyaw whitening. Raws li "Materia Medica", cov nyhuv whitening ntawm glabridin yog 232 npaug ntawm cov vitamin C zoo tib yam, thiab 16 npaug siab dua li ntawm hydroquinone. "Arbutin" 1164 zaug, yog li Glabridin hu ua "whitening kub".
2. Anti-inflammatory nyhuv
Kev tiv thaiv kev ua haujlwm ntawm glabridin tau txheeb xyuas los ntawm kev sim. Cov npua guinea tau irradiated nrog ultraviolet rays ua rau pigmentation, thiab ces 0.5 feem pua glabridin tov tau siv rau nws. Nws tau pom tias glabridin txo cov tawv nqaij mob los ntawm ultraviolet stimulation. Erythema ntawm daim tawv nqaij yog sawv cev los ntawm tus nqi. Los ntawm kev sau tus nqi (xim meter nyeem) ntawm glabridin ua ntej thiab tom qab irradiation, cov qib ntawm o tuaj yeem raug xam. Cov kws tshawb fawb tau kawm txog cov haujlwm ntawm glabridin hauv inhibiting cyclooxygenase. Cyclooxygenase yog cov enzyme uas hloov arachidonic acid mus rau hauv prostaglandins, uas yog pro-inflammatory yam. Piv nrog rau pawg tswj hwm (siv tam sim no cyclooxygenase inhibitor, indomethacine), glabridin tuaj yeem ua tiav cov txiaj ntsig ntawm inhibiting cyclooxygenase. Nws ntseeg tau tias glabridin cuam tshuam rau kev tsim cov arachidonic acid los ntawm inhibiting cyclooxygenase, yog li txo qhov mob.
3. Antioxidant nyhuv
Glabridin muaj cov txiaj ntsig zoo ntawm kev tshem tawm cov dawb radicals. Vitamin C, vitamin E thiab -carotene tau lees paub tias yog peb tus huab tais ntawm kev tiv thaiv oxidation thiab tiv thaiv kev laus. Glabridin lub peev xwm los tiv thaiv kev laus yog piv rau cov vitamin E. Oxidant, nws tau tshaj tawm tias cov nyhuv antioxidant ntawm nws cov antioxidant yog qhov zoo dua li ntawm BHA thiab BHT. [3] Nws tau raug tshaj tawm hauv cov ntaub ntawv hais tias licorice tuaj yeem siv los txo corticosteroids hauv cov kab mob ntawm daim tawv nqaij thiab tuaj yeem txhim kho cov nyhuv ntawm steroids.
Ntu 3. Kev siv tshuaj pleev ib ce
Glabridin muaj cov tshuaj tiv thaiv zoo heev, tiv thaiv oxidative thiab tiv thaiv melanin tsim cov teebmeem, yog li nws yog siv los ua cov khoom siv hauv ntau yam tshuaj pleev ib ce thiab cov khoom kho mob (xws li lub ntsej muag cream, tshuaj pleev ib ce, da dej gel, thiab lwm yam). Nws tuaj yeem ua rau lub ntsej muag dawb, thiab twb muaj cov khoom lag luam patented ntawm lub khw.
Kev noj tshuaj:Hauv cov tshuaj pleev ib ce, txhawm rau ua tiav cov nyhuv whitening, patent pom zoo koob tshuaj yog {{0}}}001-3 feem pua glabridin, nyiam dua 0.001-1 feem pua . Nrog glycerol 1: 10, ntxiv ntawm qhov kub thiab txias. Glabridin rau kev siv sab nraud tuaj yeem inhibit qhov tsim ntawm melanin. Nws muaj kev ua haujlwm zoo tyrosinase inhibitory thiab tuaj yeem tiv thaiv daim tawv nqaij tanning, kab me ntsis thiab tshav kub. Cov koob tshuaj pom zoo yog 0 0007-0 05 feem pua . Cov kev tshawb fawb tau pom tias ntev li 0.05 feem pua glabridin, 0.3 feem pua aloe hmoov, 1 feem pua nicotinamide, thiab 1 feem pua AA2G tuaj yeem inhibit melanin tyrosinase los ntawm 98.97 feem pua, yog tias nws yog txhawm rau inhibit txiv neej cov tshuaj hormones thiab kho pob txuv, lub teeb pom kev zoo ntawm Glycyrrhizin yog 0. .01-0.5 feem pua .
Hauv Suav teb, cov kws tshawb fawb kuj tau kawm txog kev npaj ntawm glabridin liposome thiab nws daim ntawv thov hauv tshuaj pleev ib ce. Cov txiaj ntsig tau pom tias glabridin liposomes tuaj yeem npaj tau zoo los ntawm kev siv liposome qauv thiab kev npaj technology. Lub phospholipid bilayer daim nyias nyias ntawm glabridin liposome zoo ib yam li cov kab mob lom, uas yooj yim rau fuse nrog cov kab mob lom, txhawb kev nkag mus ntawm cov khoom xyaw ua haujlwm rau cov kab mob lom, thiab ua rau kev xa khoom zoo ntawm cov khoom xyaw ua haujlwm thoob plaws ntawm daim tawv nqaij thiab biomembrane siab dua. Nws muaj cov txiaj ntsig zoo ntawm kev txhim kho nws cov tawv nqaij dawb thiab tshem tawm cov pob txha thiab lwm yam kev pabcuam.
