Sophocarpine hmoov

KINTAI 98%Sophoracarpine hmoovCov khoom lag luam yog muab los ntawm cov txiv hmab txiv ntoo qhuav ntawm cov nroj tsuag leguminous Sophora alopecuroides L. Los ntawm kev tshaj tawm thiab kev ua kom huv huv, KINTAI muaj peev xwm tsim cov purity sophoracarpine rau ntawm kev lag luam nrog kev ruaj ntseg zoo.

Sophora alopecuroides L.

98% Sophoracarpine

Nws muaj zog tiv thaiv kab mob, tiv thaiv qog, analgesic, tiv thaiv khaus thiab lwm yam teebmeem. Cov khoom yog ib rab koob dawb zoo li crystalline hmoov nrog lub melting point ntawm 54-55 degree . Nws yog soluble hauv cov kuab tshuaj organic xws li methanol, ethanol thiab benzene, thiab me ntsis soluble hauv dej. Nws cov teebmeem pharmacological ua rau nws muaj txiaj ntsig zoo rau cov tshuaj kho mob, tshwj xeeb tshaj yog nyob rau hauv kev kho mob qog noj ntshav, thiab tiv thaiv kab mob thiab tiv thaiv daim siab fibrosis.

KINTAI 98%Sophocarpine hmoovyog tsim los ntawm cov txheej txheem nruj. Peb xaiv cov noob taum iab loj hlob hauv Ningxia, Xinjiang thiab lwm qhov chaw hauv Suav teb sab hnub poob, uas muaj qhov zoo ntawm kev ua ntuj thiab tsis muaj tshuaj tua kab. Cov txheej txheem extraction feem ntau yog raws li cov kuab tshuaj extraction, ua ke nrog dej extraction thiab cawv extraction, thiab ces ntxiv surfactants los txhim kho tus nqi extraction. Cov tshuab no ua kom lub siab purity thiab ntau lawm efficiency ntawm sophocarpine.

Cov kauj ruam tseem ceeb ntawm kintai extraction yog kev siv lub zog acid cation txauv resin kem thev naus laus zis, uas tuaj yeem ua kom zoo adsorb alkaloid Cheebtsam thaum tsis suav nrog cov tsis-alkaloid compounds. Piv nrog rau cov txheej txheem rho tawm ib txwm muaj, cov txheej txheem no tuaj yeem tsis tsuas yog txhim kho cov txiaj ntsig ntawm sophocarpine, tab sis kuj muaj txiaj ntsig zoo rau kev lag luam. Lub cev thiab tshuaj lom neeg ruaj khov ntawm resin adsorption yog siab, qhov kev xaiv muaj zog, nws tsis cuam tshuam los ntawm cov tshuaj inorganic, thiab nws tuaj yeem rov tsim dua tshiab thiab siv ntau zaus, uas txuas ntxiv lub neej kev pabcuam ntawm cov khoom siv thiab txo cov nqi tsim khoom. Yog li, cov txheej txheem no yog siv dav hauv kev tsim khoom ntawm KINTAI's alkaloid series khoom.

Txhawm rau kom ntseeg tau tias qhov zoo thiab purity ntawm sophocarpine, KINTAI siv kev ua haujlwm siab ua kua chromatography (HPLC) thiab kua chromatography-mass spectrometry (LC-MS) rau kev kuaj. Qhov no tuaj yeem txheeb xyuas qhov tseeb thiab ceev nrooj hloov pauv hauv cov ntsiab lus ntawm sophocarpine, kom ntseeg tau tias qhov purity ntawm txhua pawg ntawm cov khoom nce mus txog ntau dua 98%. Qhov kev tswj xyuas nruj nruj no ua kom ntseeg tau tias KINTAI cov khoom lag luam sophocarpine ua tau raws li kev lag luam nruj heev rau cov alkaloids siab dawb huv.

1. Anti-inflammatory thiab analgesic teebmeem
Sophocarpine nthuav tawm cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob tseem ceeb los ntawm inhibiting inflammatory channels xws li TRPA1 thiab TRPV1. Cov kev tshawb fawb tau pom tias nyob rau hauv tus qauv nas tsis haum rau tus kab mob dermatitis, sophocarpine tuaj yeem txo qis tus cwj pwm thiab txo cov theem ntawm proinflammatory yam qog necrosis factor- (TNF- ) thiab interleukin -1 (IL-1) hauv tawv nqaij. Tsis tas li ntawd, sophocarpine txo qhov tshwm sim ntawm khaus thiab mob los ntawm kev cuam tshuam nrog kev ua haujlwm ntawm TRPA1 thiab TRPV1 raws.

Hauv kev sim tsiaj, nas tau muab faib ua 7 pawg los kawm txog kev cuam tshuam ntawm kev sib txawv ntawm cov tshuaj sophocarpine ntawm kev tsis haum tshuaj tiv thaiv kab mob dermatitis (ACD) pruritus. Cov tshuaj sophocarpine ntau npaum li cas (60 mg / kg) txo qis qhov khaus ntawm ze li ntawm 90 zaug mus txog 25 zaug, qhia tias sophocarpine muaj qhov cuam tshuam los tiv thaiv khaus khaus.

Sophocarpine kuj tseem cuam tshuam qhov kev tso tawm ntawm lwm yam khaus los ntawm kev txo cov kev qhia ntawm proinflammatory yam, uas muab kev txhawb nqa ntau dua rau nws cov tshuaj tiv thaiv.

2. Cov nyhuv tiv thaiv qog
Sophocarpine muaj qhov cuam tshuam loj heev rau ntau hom qog nqaij hlav, tshwj xeeb tshaj yog rau cov qog nqaij hlav. Cov kev tshawb fawb tau pom tias sophocarpine tuaj yeem cuam tshuam qhov kev loj hlob, kev tsiv teb tsaws thiab kev cuam tshuam ntawm cov qog nqaij hlav cancer thiab txhawb lawv cov apoptosis los ntawm ntau yam txheej txheem. Piv txwv li, sophocarpine muaj qhov cuam tshuam loj heev rau kev loj hlob ntawm cov qog nqaij hlav hauv tsev menyuam HeLa hlwb hauv vitro thiab tuaj yeem ua rau muaj kev cuam tshuam ntawm cov qog hlwb. Tsis tas li ntawd, sophocarpine kuj muaj cov nyhuv immunomodulatory, tuaj yeem ua rau cov qe ntshav dawb nce ntxiv, thiab txo cov tsos mob ntawm cov neeg mob qog noj ntshav, uas ua rau nws muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav.

3. Anti-cancer nyhuv
Lub in vitro proliferation inhibitory nyhuv ntawm sophocarpine ntawm daim siab mob hlwb HepG2 thiab qog nqaij hlav qog noj ntshav HeLa tau kawm dav. Cov kws tshawb fawb tau siv MTT txoj hauv kev los txiav txim qhov muaj sia nyob ntawm cov qog nqaij hlav cancer ntawm qhov sib txawv ntawm sophocarpine, thiab kuaj pom cov cell apoptosis induced los ntawm sophocarpine los ntawm cytometry ntws.

Cov txiaj ntsig Sophocarpine tuaj yeem cuam tshuam loj heev ntawm HepG2 thiab HeLa hlwb nyob rau hauv cov koob tshuaj, thiab ua rau apoptosis ntawm cov qog nqaij hlav cancer ntawm qhov siab. Piv nrog rau pab pawg tswj hwm, cov cell ciaj sia taus ntawm cov pab pawg kho mob sophocarpine poob li ntawm 60%. Sophocarpine tswj txoj hauv kev Bcl-2/Bax apoptosis, txhawb kev nthuav qhia ntawm apoptosis-hais txog cov proteins, thiab inhibits kev loj hlob thiab tsiv teb tsaws ntawm cov qog nqaij hlav cancer los ntawm kev txo qis PI3K / Akt signaling pathway. Tsis tas li ntawd, sophocarpine ntxiv inhibits kev loj hlob ntawm cov qog nqaij hlav cancer los ntawm inhibiting qog angiogenesis thiab txo cov khoom noj khoom haus ntawm cov qog hlwb.

4. Kev kho mob khaus khaus thiab khaus tawv nqaij
Sophocarpine tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm daim tawv nqaij. Los ntawm inhibiting TRP channel, sophocarpine tuaj yeem txo cov tsos mob khaus khaus los ntawm kev tsis haum rau dermatitis (ACD). Cov kev tshawb fawb tau pom tias sophocarpine tuaj yeem txo qis cov qog necrosis factor- (TNF- ) thiab interleukin -1 (IL-1 ) hauv daim tawv nqaij, inhibit qhov overexpression ntawm inflammatory yam, thiab txo tus cwj pwm khawb. ntawm nas, qhia tau zoo los tiv thaiv kab mob. Cov nyhuv no ua rau cov tshuaj sophocarpine rau kev kho mob ntawm daim tawv nqaij khaus khaus, tshwj xeeb tshaj yog rau kev kho mob ntawm daim tawv nqaij kab mob xws li eczema thiab dermatitis.

5. Kev tiv thaiv zoo ntawm cov hlab plawv
Kev txhaj tshuaj ntawm cov tshuaj sophocarpine tuaj yeem ua rau cov ntshav siab ntawm cov tsiaj ua ntej thiab tom qab ntawd poob, thiab muaj kev cuam tshuam rau lub plawv thiab vascular system. Nws muaj cov txiaj ntsig zoo inotropic rau lub plawv, tuaj yeem ua rau lub plawv dhia, thiab tshwj xeeb tshaj yog tsim nyog rau kev kho mob ntawm lub plawv tsis ua haujlwm. Cov kev sim qhia tau hais tias sophocarpine muaj qhov cuam tshuam tseem ceeb rau ntau yam qauv uas ua rau muaj kev mob arrhythmias, tshwj xeeb tshaj yog ventricular arrhythmias.

Sophocarpine kuj tseem tuaj yeem nthuav cov hlab ntsha peripheral, txo cov vascular tsis kam, thiab qhia txog cov nyhuv antihypertensive. Nws cov txheej txheem antihypertensive feem ntau yog cuam tshuam nrog vasodilation, thaiv kev sympathetic ganglia, thiab tsis ncaj qha cuam tshuam ntawm lub paj hlwb ntawm lub plawv.

6. Antiasthmatic nyhuv
Sophocarpine kuj qhia tau hais tias muaj zog antiasthmatic thiab tiv thaiv kev ua xua. Cov kev tshawb fawb tau pom tias sophocarpine tuaj yeem txo cov bronchospasm zoo los ntawm kev txhawb nqa lub hauv paus receptors thiab muaj cov nyhuv antitussive. Qhov kev tshawb pom no muab kev txhawb nqa theoretical rau kev siv cov tshuaj sophocarpine hauv kev kho mob hawb pob thiab lwm yam kab mob ua pa.

7. Central paj hlwb cuam tshuam
Kev sim tau pom tias sophocarpine tuaj yeem cuam tshuam qhov kev ua haujlwm ntawm cov nas, txhim kho cov teebmeem ntawm lub hauv nruab nrab lub paj hlwb kev nyuaj siab xws li sodium pentobarbital, thiab antagonize lub psychomotor excitement ntawm nas los ntawm amphetamine. Nws kuj tseem tuaj yeem txo qhov writhing cov tshuaj tiv thaiv ntawm nas los ntawm acetic acid thiab txo lub cev kub ntawm nas, qhia tias nws muaj sedative, analgesic thiab txias los.

Tsis tas li ntawd, sophocarpine tseem tuaj yeem tswj hwm dopamine metabolites hauv nas hlwb, nce cov ntsiab lus ntawm dihydroxyphenylacetic acid (DOPAC) thiab homovanillic acid (HVA), thiab qhia zoo li lub hauv paus paj hlwb cuam tshuam rau tag nrho cov alkaloids ntawm Sophora alopecuroides.

98% yogSophocarpine hmoovua los ntawm KINTAI ua kom lub siab purity thiab ruaj khov ntawm nws cov khoom nrog nws cov txheej txheem rho tawm tau zoo thiab kev tswj xyuas nruj. Hauv kev tsim khoom, cation txauv resin adsorption tshuab yog siv los txhim kho cov txiaj ntsig zoo ntawm sophocarpine thiab txo cov nqi tsim khoom. Tsis tas li ntawd, kev tiv thaiv ib puag ncig thiab kev lag luam ntawm cov txheej txheem ua rau KINTAI muab cov nqi sib tw ntau dua thiab txhawb nqa kev siv ntau ntawm sophocarpine hauv ntau qhov chaw.

Nrog rau kev siv dav ntawmSophocarpine hmoovhauv kev tshawb fawb pharmacological, nws txoj kev lag luam xav tau kuj nce ntxiv. Raws li ib tug natural alkaloid, lub pharmacological mechanism ntawm sophocarpine koom nrog ntau txoj kev taw qhia molecular, xws li TRPA1 thiab TRPV1 raws, Bcl-2/Bax apoptosis pathway, PI3K / Akt signaling pathway thiab calcium ion channel. Sophocarpine tsis tsuas yog muaj peev xwm ncaj qha cuam tshuam cov kab mob pathological, tab sis kuj tuaj yeem txhim kho lub cev kho tus kheej lub peev xwm los tua cov kab mob los ntawm kev tswj hwm lub cev. Yog li ntawd, nws tsis tsuas yog tseem ceeb daim ntawv thov nqi nyob rau hauv lubchaw kws tshuaj, tab sis kuj yog dav siv nyob rau hauv lubcov khoom kho mobthiabtshuaj pleev ib ce kev lag luam. Piv txwv li, nyob rau hauv cov tshuaj pleev ib ce, sophocarpine feem ntau yog siv nyob rau hauv high-end khoom tu tawv nqaij vim nws anti-inflammatory, antioxidant thiab daim tawv nqaij-soothing zog los pab txo cov tawv nqaij o thiab ua xua.

Feem ntau, KINTAI's 98% sophocarpine hmoov cov khoom tau qhia ntau yam ntawm daim ntawv thov kev cia siab nrog nws cov purity siab, ruaj khov zoo thiab ntau yam tshuaj. Raws li tib neeg them nyiaj ntau dua thiab ntau dua rau cov nroj tsuag ntuj, sophocarpine, ua ntau yam tshuaj ntuj, yuav muaj tseeb ua lub luag haujlwm tseem ceeb hauv kev kho mob thiab kev noj qab haus huv yav tom ntej. KINTAI yuav txuas ntxiv muab cov khoom lag luam zoo sophocarpine rau lub ntiaj teb kev lag luam thiab txhawb kev txhim kho kev noj qab haus huv kev lag luam los ntawm kev vam khom cov thev naus laus zis thev naus laus zis thiab kev tswj hwm nruj.

★ Yog tias koj xav tau cov khoom zooSophocarpine hmoov, thov koj xav tiv tauj peb ntawmsales@kintaibio.comlos yog tawm tswv yim nyob rau nplooj ntawv tom ntej.

Cim npe nrov: Tuam Tshoj sophocarpine hmoov manufacturers, lwm tus neeg, Hoobkas