Aconite hauv paus Aconitum Kusnezoffii Extract

Xi'an Kintai Biotech Inc yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm aconite cag aconitum kusnezoffii extract hauv Suav teb. Thov koj xav tias dawb rau cov lag luam wholesale zoo aconite cag aconitum kusnezoffii extract rau muag ntawm no los ntawm peb lub hoobkas. Rau nqe kev sab laj, tiv tauj peb.

KINTAIBIO^®tshwj xeeb hauv kev tshawb fawb, kev tsim kho, kev tsim khoom, thiab kev muab khoom zoo ntawm - zooAconite hauv paus Aconitum Kusnezoffii Extract, muab tau los ntawm qhuav hauv paus tubers ntawmAconitum kusnezoffii Reichb., ib tsob nroj hauv tsev neeg Ranunculaceae. Cia siab rau cov txheej txheem rho tawm cov txheej txheem thiab kev tswj hwm kev ua tau zoo, peb tau cog lus los muab cov tuam txhab tshuaj, cov chaw tshawb fawb, thiab cov khoom tsim kho ntuj tsim nrog kev nyab xeeb, txhim khu kev qha, thiab batch- cog ruaj khov-raws li cov khoom xyaw.Aconite extractyog nplua nuj nyob rau hauv ntau yam diterpenoid alkaloids, suav nrog diester-hom, monoester- hom, thiab lwm yam alkaloids yam ntxwv, muab nws cov tshuaj tseem ceeb thiab kev tshawb fawb.

Cog Base ntawm Aconitum sinomontanum Nakai

Cov hauv paus hniav ntawm Aconitum sinomontanum Nakai

Qhuav Aconite hauv paus

Lappaconitine Hydrobromide

Raws li qhov no,KINTAIBIO^®ntxiv enriches thiab npaj cov khoom xyaw tseem ceeb siv kev sib cais thiab purification technologies, muab tshuaj raw cov ntaub ntawv xws lilappaconitine hydrobromidenrog purity txog li96%. Thaum lub sij hawm cov txheej txheem ntau lawm, peb nruj me ntsis tswj cov ntsiab lus thiab kev faib ua feem ntawm cov tseem ceeb diterpenoid alkaloids kom paub meej cov khoom zoo stability, zoo batch sib xws, thiab txhim khu kev qha zoo.

Aconite hauv paus Aconitum Kusnezoffii Extract qauv

Aconite hauv paus Aconitum Kusnezoffii Extract cov ntsiab lus

Nrog advanced extraction, purification, thiab crystallization txheej txheem, muaj kev tswj kom zoo, thiab ruaj khov muaj peev xwm,KINTAIBIO^®tuaj yeem muab customizedLappaconitine Hydrobromide hmoovcov khoom sib txawv ntawm cov kev qhia tshwj xeeb thiab txuas ntxiv, kev txhawb nqa ruaj khov raws li cov neeg siv khoom xav tau, ua haujlwm ntau yam xws li kev tsim tshuaj, kev tshawb fawb ntawm cov khoom ntuj tsim, thiab kev txhim kho cov tshiab uas tsis yog -kev quav tshuaj quav cawv thiab lwm yam tshuaj. Kev cia siab rau qhov kawg-rau- xaus qhov zoo ntawm kev taug qab los ntawm cov khoom siv raw mus rau siab -purity active cov khoom xyaw, Peb tau cog lus los ua tus neeg muag khoom ntseeg siab ntawm aconite- muab cov khoom xyaw ntuj rau cov neeg siv khoom thoob ntiaj teb. Xav tias dawb hu rau peb online ntawmsales@kintaibio.com. 

Lub ntsiab active Cheebtsam ntawmAconite hauv paus Extractyog diterpenoid alkaloids, suav nrog:

• Diester -diterpenoid alkaloids:xws li aconitine, hypaconitine, thiab mesaconitine. Cov tebchaw no nthuav tawm cov haujlwm lom neeg tseem ceeb tab sis kuj yog qhov tseem ceeb ntawm toxicity.
• Monoester -diterpenoid alkaloids:xws li benzoylaconine, uas muaj toxicity tsawg dua piv rau diester -hom alkaloids.
• Lwm yam alkaloids:los ntawm Aconitum kusnezoffii, ntxiv alkaloids xws li deoxyaconitine, beiwutine, thiab 1,15-dimethoxy-3-hydroxy-14-benzoyl-16-ketooline tau raug cais tawm.

Cov lus: Cov khoom tseem ceeb Alkaloid hauv Aconite hauv paus thiab lawv cov khoom

Los ntawm cov txheej txheem txheem, peb cov khoom siv -96% Lappaconite Hydrobromide- xyuas kom muaj kev tswj hwm nruj ntawm cov ntsiab lus thiab qhov sib piv ntawm peb qhov tseem ceeb diester -diterpenoid alkaloids. Qhov no tau lees paub cov khoom sib xws - rau- batch stability thiab cov khoom zoo, txhim khu kev ua tau zoo thiab kev nyab xeeb.

Key Component Control
Cov khoom xyaw nquag: Benzolaconitine: 40.0% -55.0%; Lwm yam Monoester Alkaloids: 15.0% -25.0%
Toxic Component Limits:Aconitine:<0.005%; Mesaconitine: <0.004%  Hypaconitine: <0.003%

Cov khoom no siv cov txheej txheem tshiab detoxification kom tshem tawm cov tshuaj lom tag nrho thaum khaws cov khoom xyaw nquag ntawmAconitum paus. Qhov no muab siab - cov ntaub ntawv zoo rau kev nyab xeeb ntawm lappaconitine hydrobromide. Peb tos ntsoov yuav tsim kom ntev - lub sij hawm, ruaj khov kev koom tes nrog cov tuam txhab tshuaj loj los koom ua ke ua kom muaj kev kho tshiab ntawm cov tshuaj botanical.

Primary Extraction thiab Component Enrichment

Cov khoom no siv cov txheej txheem optimized ethanol reflux rau thawj extraction. Los ntawm kev tswj xyuas cov khoom ua tau zoo- rau- kua piv (1:10), ethanol concentration (75%), thiab lub sij hawm rho tawm (2 teev), kev ua kom zoo ntawm diterpenoid alkaloids tiav. Tom qab ntawd, cov extract yog raug rau gradient elution tshaj NKA-II thiab X-4 macroporous adsorption resins rau thawj purification thiab enrichment ntawm tej yam. Cov kauj ruam no tsis yog tsuas yog ua kom muaj cov ntsiab lus ntawm tag nrho cov alkaloid los ntawm thawj 5.87% mus rau 60.3%, tab sis kuj tseem cais cov alkaloids ntawm qhov sib txawv polarity, nteg lub hauv paus ruaj khov rau tom qab high-purity purification.

Multi-theem Purification thiab Refining

Raws li kev ua kom huv huv thawj zaug, peb siv thim rov qab -theem npaj chromatography rau kev ua kom huv ntxiv. Cov txheej txheem no siv C18 bonded silica raws li theem nyob ruaj khov thiab ib qho acetonitrile-phosphate buffer system raws li lub sijhawm txawb, sib cais cov qauv zoo ib yam li alkaloid Cheebtsam. Los ntawm cov kauj ruam no kom huv si, peb ua kom muaj kev coj dawb huv ntawm cov khoom xyaw tseem ceeb tshaj li 85%, ua tiav kev hloov pauv ntawm cov khoom siv raw mus rau siab -purity intermediates, ua kom tau raws li cov kev cai nruj rau cov khoom siv raw khoom.

Targeted Toxicity Reduction thiab tag nrho -Kev Tswj Xyuas Zoo

Txhawm rau kom muaj kev nyab xeeb ntawm qhov kawg ntawm cov khoom kawg, peb tau tsim cov patented gradient pH - tswj cov txheej txheem hydrolysis thiab tag nrho - txheej txheem tshuaj lom neeg taug qab qhov system. Cov txheej txheem hydrolysis, ua nyob rau ntawm qhov kub thiab txias ntawm 60-80℃thiab pH ntau ntawm 3.5-5.5, ua tau zoo thiab muaj txiaj ntsig zoo hloov pauv cov tshuaj lom diester alkaloids rau hauv cov tshuaj lom monoester alkaloids tsawg, ua tiav qhov diester alkaloid tshem tawm tus nqi kom siab dua 9% ntau dua los yog sib npaug. tshaj los yog sib npaug li 95%. Tsis tas li ntawd, peb siv HPLC-MS txuas thev naus laus zis (kev kuaj pom qhov txwv 0.1 ug / g) rau kev saib xyuas lub sijhawm ntawm aconitine, mesaconitine, thiab mesaconitine, nruj me ntsis xyuas kom meej tias tag nrho cov nqi ntawm diester alkaloids hauv cov khoom kawg yog tsawg dua 0.01%, ua kom muaj kev nyab xeeb ntawm cov chaw muag tshuaj.

Aconite hauv paus Extractmuaj ntau yam kev siv hauv cov tshuaj thiab tshuaj pleev ib ce:

• Kev siv tshuaj analgesic:Haum rau kev tswj cov mob ntev xws li mob caj dab rheumatoid, mob qog noj ntshav siab, khov lub xub pwg, lumbar leeg mob, mob nraub qaum, thiab sciatica.
• Kev tiv thaiv - Cov ntawv thov mob:Nws muaj cov txiaj ntsig zoo rau ntau yam kab mob xws li myofibrosarcoma, costochondritis, thiab herpes zoster.

• Kev npaj cov ntsiab lus:Peb cov kev tshawb fawb tau pom tias ib qho gel formulation ntawmAconite kusnezoffii standardized extractmuab cov txiaj ntsig zoo xws li kev tso tshuaj sai sai, daim ntawv thov tsis sib xws thiab du, thiab daim ntawv thov yooj yim. Nws kuj tseem muaj kev nyab xeeb dua li cov qauv kev daws teeb meem (cov qauv gel muaj qhov sib txawv ntawm 128-fold ntawm qhov siab tshaj plaws thiab cov koob tshuaj zoo, thaum lub LD50 ntawm cov tshuaj formulation tsuas yog kwv yees li 5-fold sib txawv ntawm cov koob tshuaj ua kom zoo).

• Transdermal Drug Delivery System: Cov tsim Aconite kusnezoffii standardized extract thaj yog ib daim nyias nyias -tswj tso tawm thaj, siv cov carbomer gel raws li ib tug reservoir, ib tug ethylene -vinyl acetate copolymer zaj duab xis raws li ib tug tswj - tso tawm daim nyias nyias, thiab ib tug silicone siab -sensitive adhesive txheej. Nws tuav tus nqi hloov pauv tsis tu ncua rau 48 teev.

KINTAIBIO^®'s Aconite hauv paus Aconitum Kusnezoffii Extractmuab cov kev txawj ntse ntawm cov tshuaj suav tshuaj suav nrog cov cuab yeej siv tshuaj niaj hnub los muab rau koj nrog siab -zoo, qauv, thiab nyab xeeb thiab txhim khu kev qhaAconitum kusnezoffii extract. PebLappaconitine Hydrobromide
cov khoom ua raws li cov qauv kev tswj xyuas nruj, tswj xyuas cov ntsiab lus thiab qhov sib piv ntawm cov khoom xyaw nquag kom ntseeg tau tias kev ua tau zoo thiab kev nyab xeeb ntawm batch mus rau batch.

Txawm siv nyob rau hauv kev tsim tshuaj formulation los yog tshuaj pleev ib ce formulation, peb muaj peev xwm muab rau koj zoo heevAconite hauv paus Aconitum Kusnezoffii Extractkhoom kev paub.Thov hu rau peb kom paub ntau ntxiv txog cov khoom specifications, technical data, thiab kev sib koom tes. Thov koj xav tiv tauj peb ntawmsales@kintaibio.comlos yog muab tswv yim rau nplooj ntawv tom ntej.

Cim npe nrov: Aconite hauv paus Aconitum Kusnezoffii Extract, Tuam Tshoj Aconite hauv paus Aconitum Kusnezoffii Extract manufacturers, lwm tus neeg, Hoobkas