Corosolic Acid Banaba nplooj Extract

Raws li cov pov thawj scientific uas tau hais tseg,Corosolic Acid Banaba nplooj ExtractFeem ntau yog siv rau kev tiv thaiv thiab kev kho mob ntawm hom II mob ntshav qab zib thiab rog rog. Nws tuaj yeem ua cov khoom siv tseem ceeb hauv cov khoom noj khoom haus zoo nkauj thiab tuaj yeem tsim kho rau hauv cov chaw muag tshuaj lossis cov khoom noj qab haus huv nrog hypoglycemic, hnyav- poob, tiv thaiv- mob, thiab tiv thaiv- qog nqaij hlav. Hauv nws daim ntawv thov, nws lub hauv paus chiv keeb thiab maj mam pib ua haujlwm ua rau nws muaj kev nyab xeeb thiab ruaj khov nroj tsuag -raws li insulin lwm txoj.Peb kuj muab Corosolic Acid rho tawm los ntawm Loquat nplooj. Yog xav paub ntxiv txogcorosolic acid hmoov, thov hu rau peb ntawmsales@kintaibio.com.

• Morphological yam ntxwv:Lagerstroemia speciosa (L.) Pers. Nws yog tsob ntoo loj ntawm genus Lagerstroemia hauv tsev neeg Lythruceae. Txog li 25 meters siab; Cov tawv nqaij grey, du; Columella cylindrical, glabrous los yog me ntsis furfural batch plaub hau. Nplooj tawv, oblong elliptic los yog oval oval, sparsely lanceolate, sab saum toj obtuse los yog luv taw tes, puag broadly cuneate mus puag ncig; Petiole 6-15 mm ntev, stout. Paj lub teeb liab los yog ntshav, 5 cm inch, terminal panicle 15-25 cm ntev; Lub pedicel yog 1-1.5 cm ntev, thiab rachis, pedicel thiab calyx yog them nrog yellowish xim av pith zoo li felts; Calyx muaj 12 tav tav thiab npog nrog pith zoo li cov plaub hau; Cov nplooj ntawm suborbicular mus rau oblong obovate. Capsule globose rau obovate oblong; Noob heev, 10-15 mm ntev. Lub sij hawm flowering yog los ntawm lub Tsib Hlis mus rau Lub Xya hli ntuj, thiab fruiting lub sij hawm yog los ntawm Lub kaum hli ntuj mus rau Kaum ib hlis.

• Qhov chaw faib khoom:Nws tau muab faib rau hauv Sri Lanka, Is Nrias teb, Malaysia, Nyab Laj, Philippines thiab Tuam Tshoj. Nws tau muab faib rau hauv Guangdong, Guangxi, Fujian thiab Taiwan hauv Suav teb. Nws yog feem ntau faib rau hauv qhov chaw qis qis, loj hlob hauv qhov chaw zoo xws li cov dej ntws thiab marshes, tab sis kuj tuaj yeem loj hlob hauv hav zoov ntawm cov av alluvial.

Banaba nplooj Extract poob phaus

Cov kev tshawb fawb tau pom tias kev sib xyaw ntawm txiv tsawb extract thiab cov probiotics tshwj xeeb hauv 1: 1 pivtxo qhov hnyav nce thiab cov nqaij adipose dawb nthuav dav hauv siab - noj zaub mov rog - ntxias cov nas rog rog. Qhov kev sib koom ua ke no tau pom tias muaj kev cuam tshuam tseem ceeb ntawm cov noob adipogenesis tseem ceeb ntawm mRNA, tswj cov txheej txheem tsim tawm adipocytes ntawm nws qhov chaw. Tsis tas li ntawd, kev sib xyaw ua ke no tseem txo qis cov ntshav qabzib yoo mov hauv cov qauv nas rog rog, txhim kho cov tshuaj insulin tiv thaiv los ntawm kev noj zaub mov muaj roj ntau.

 

Lub caij no,Banaba nplooj Extract corosolic acidib leeg kuj tau nthuav tawm dav -spectrum metabolic regulatory teebmeem, thiab nws qhov hnyav- poob peev xwm ntawm tib neeg tau raug lees paub hauv kev tshawb fawb soj ntsuam. Qhov tshwj xeeb, hauv cov kev sim tsiaj uas tau hais los saum no, cov khoom siv probiotic sib xyaw ua kom pom kev nyab xeeb profile piv rau ib leeg - cov tshuaj tua kab mob, ua kom muaj txiaj ntsig zoo nrog kev siv nyab xeeb.

Banaba nplooj corosolic acid ntshav qab zib

Ntau qhov randomized, ob npaug - qhov muag tsis pom kev kuaj mob tau lees paub qhov tseeb thiab txhim khu kev qha lub cev muaj txiaj ntsig ntawm qhov ncauj txiv tsawb extract supplementation hauv kev txhim kho cov piam thaj metabolism thiab insulin tsis kam.Ib qho randomized, ob npaug - qhov muag tsis pom, placebo- tswj kev sib tw sib tw hauv nruab nrab- cov txiv neej hnub nyoog uas muaj cov piam thaj tsis haumpom tau hais tias kev noj tshuaj txhua hnub nrog 1 mg corosolic acid rau ob lub lis piam txo qhov chaw nyob hauv qab nkhaus (AUC) ntawm cov ntshav qabzib nce ntxiv hauv qhov ntsuas qhov ncauj qhov siab piv rau cov placebo pawg. Nyob rau tib lub sijhawm, cov tshuaj insulin hauv cov ntshav thiab C-peptide concentrations tau txo qis raws li, thiab cov tshuaj insulin rhiab heev ntawm lub siab tau ua kom zoo dua.

Mechanistically,txiv tsawb nplooj extractaccelerates qabzib uptake nyob rau hauv peripheral cov ntaub so ntswg los ntawm kev txhawb lub translocation ntawm cov piam thaj transporter GLUT4 mus rau lub cell membrane. Qhov "insulin-zoo li" cov nyhuv no tau txais nws lub npe ntawm "insulin cog." Tsis tas li ntawd, kev tshawb fawb tau qhia tiastxiv tsawb nplooj corosolic acidtuaj yeem qhib lub adenosine monophosphate-activated protein kinase (AMPK) qhia txoj hauv kev, yog li ua kom muaj zog insulin rhiab heev thiab inhibiting hepatic gluconeogenesis.

Banaba nplooj Extract Antioxidant kev ua haujlwm

Raws litus qauv zebrafish ntxias los ntawm cov khoom noj muaj roj (cholesterol) siab thiab siab -galactose noj, cov extract no tau pom qhov tseem ceeb thiab muaj txiaj ntsig ntawm lub cev muaj txiaj ntsig hauv kev tawm tsam oxidative kev nyuaj siab. Nyob rau hauv txoj kev tshawb no, ob qho tib si no extract ib leeg thiab ua ke nrog polyeicosanol zoo nce plasma tag nrho sulfhydryl cov ntsiab lus, paraoxygenase (PON) kev ua, thiab ferric txo kev ua si (FRA), qhia ncaj qha qhia txog kev txhim kho tag nrho cov antioxidant muaj peev xwm.

 

Qhov tseem ceeb, kev sib xyaw ntawm txiv tsawb extract thiab polyeicosanol synergistically txo cov tiam ntawm reactive oxygen hom (ROS) nyob rau hauv lub hlwb induced los ntawm kev noj zaub mov tsis zoo, inhibited kev qhia ntawm apoptosis thiab cellular senescence markers, thiab txo cov tsub zuj zuj ntawm 4-hydroxynonenal (4-HNE), lipid peroxidation kawg khoom, nyob rau hauv cov ntaub so ntswg neural. Cov teebmeem antioxidant no raug ntaus nqi, ntawm ib sab, rau lub peev xwm ntawmBanaba nplooj Extract corosolic acidmus ncaj qha scavenge dawb radicals, thiab ntawm qhov tod tes, rau nws ua kom cov Nrf2/ARE signaling txoj kev thiab upregulation ntawm cov kev ua ntawm endogenous antioxidant enzyme systems.

Tau qhov twg los: https://www.mdpi.com/2079-7737/13/12/1047

https://www.sciencedirect.com/science/article/pii/S1756464622003267

https://www.mdpi.com/1424-8247/18/6/860

Banaba nplooj Extract kev nyab xeeb

Kev tshuaj xyuas kom meej meej hais tias tsis muaj qhov tshwm sim tsis zoo tau raug pom los yog tshaj tawm hauv cov kev tshawb fawb tsiaj thiab kev tswj xyuas tib neeg kev sim tshuaj;corosolic acidtau tshaj tawm kom txo cov ntshav qabzib hauv tib neeg hauv 60 feeb.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias muaj cov ntaub ntawv qhia txog tus neeg mob ntshav qab zib uas muaj lub raum tsis ua haujlwm tau tsim muaj lactic acidosis hnyav thiab mob raum mob tom qab noj corosolic acid.Tsis tas li ntawd, thaum luv - siv sijhawmtxiv tsawb nplooj extractsuav hais tias muaj peev xwm muaj kev nyab xeeb, cov ntaub ntawv muaj kev ntseeg siab txaus hais txog nws qhov ntev - tsis muaj kev nyab xeeb.

Banaba Leaf Extract ntau npaum li cas

Cov ntaub ntawv kho mob tam sim no tseem muaj tsawg thiab tsis txaus los muab cov lus pom zoo dav dav dav dav.

contraindications thiab ceev faj

Kev siv yuav tsum zam thaum cev xeeb tub thiab lactation vim tsis muaj ntaub ntawv hais txog kev nyab xeeb thiab kev ua tau zoo; ceev faj yuav tsum tau siv nyob rau hauv cov neeg mob uas lub raum tsis ua hauj lwm, raws li cov kev phiv tshwm sim nyob rau hauv cov pej xeem no; Cov neeg mob npaj phais yuav tsum tsis txhob siv yam tsawg kawg 2 lub lis piam ua ntej kev phais, vim banaba tuaj yeem cuam tshuam rau perioperative glycemic tswj.

kev sib tshuam tshuaj

Txawm hais tias tsis muaj cov ntaub ntawv sib cuam tshuam tag nrho, vim nws muaj peev xwm ua rau cov nyhuv hypoglycemic, kev sib koom ua ke nrog - noj cov tshuaj ntshav qab zib tuaj yeem ua rau cov ntshav qab zib tsawg. Tsis tas li ntawd, nws muaj peev xwm ua rau muaj kev pheej hmoo siab ntawm qib tshuaj thaum siv co- tswj hwm nrog CYP3A4 cov tshuaj substrate (xws li cyclosporine, qee yam statins, thiab calcium channel blockers).

Hauv cov ntsiab lus,Banaba nplooj Extract hmoovmuaj cov ntaub ntawv kev nyab xeeb zoo raws li kev siv niaj hnub thiab ntawm cov koob tshuaj; Txawm li cas los xij, nws yuav tsum tau siv nrog ceev faj thiab nruj me ntsis raws li cov lus qhia tshaj lij hauv cov neeg tshwj xeeb thiab cov xwm txheej tshwj xeeb.

Banaba nplooj Extractthiabua berberinefeem ntau hais ua ke ntawm cov piam thaj hauv ntshav ntuj - txo cov khoom xyaw. Ob leeg tuaj yeem pab tswj cov ntshav qab zib kom zoo rau cov neeg mob ntshav qab zib hom 2, tab sis lawv cov txheej txheem ntawm kev ua txawv:

Lub ntsiab mechanism ntawmBanaba nplooj Extractyog ua kom cov piam thaj transporter GLUT4 mus txogcorosolic acid, txhawb nqa cov piam thaj los ntawm cov leeg nqaij thiab cov rog. Cov nyhuv no zoo ib yam li insulin tab sis tsis ua rau muaj kev pheej hmoo ntawm hypoglycemia. Tib lub sijhawm, nws tuaj yeem txo qis triglycerides thiab nce siab - ntom lipoprotein (HDL-C), muaj kev cuam tshuam zoo rau lipid metabolism.

Corosolic Acid hmoov

Coptis Chinensis cag Extract hmoov

BerberineFeem ntau ua haujlwm los ntawm kev ua kom AMPK (AMP-activated protein kinase) txoj hauv kev, txhim kho cov tshuaj insulin rhiab heev thiab inhibiting hepatic gluconeogenesis, yog li txo cov ntshav qab zib. Nws kuj tseem txhim kho cov ntshav lipids, tshwj xeeb tshaj yog muaj txiaj ntsig hauv kev txo qis -lipoprotein ntom ntom (LDL-C) thiab triglycerides. Txawm li cas los xij, ib qho kev mob tshwm sim ntawm berberine yog qhov tsis xis nyob hauv plab, xws li raws plab, cem quav, lossis tsam plab.

Ob leeg ntawm cov tshuaj no tso siab rau stimulating insulin secretion kom txo cov ntshav qab zib; Yog li, qhov kev pheej hmoo ntawm hypoglycemia yog qis dua li cov tshuaj sulfonylureas. Yog tias cov qauv tsim los "mimic insulin los txhawb nqa cov piam thaj" thaum tseem txhim kho triglycerides thiab HDL-C,txiv tsawb nplooj extractyog qhov kev xaiv zoo tshaj plaws; Yog tias lub hom phiaj yog txhawm rau ntxiv dag zog rau AMPK txoj hauv kev, txwv tsis pub cov piam thaj hauv siab, thiab qis LDL -C, berberine muaj qhov tshwj xeeb zoo. Ob leeg tuaj yeem siv sib koom ua ke, tab sis nws raug nquahu kom ua li ntawd raws li kev qhia ua haujlwm.

Raws li tus kws tshaj lijtus neeg muag khoomntawmtxiv tsawb nplooj extract, peb muaj ntau xyoo ntawm kev paub hauv cov nroj tsuag extract ntau lawm.KINTAIBIO^®muaj aGMP-txheej txheem rhiav nruab nrog siab - ua kua chromatography (HPLC) thiab loj spectrometry (MS) cov khoom siv, thiab txhua pawg ntawm cov khoom tuaj nrog rau thib peb -toj xeem tsab ntawv ceeb toom. Peb koom tes nrog ntau lub koom haum tshawb fawb los txuas ntxiv txhim kho cov txheej txheem rho tawm, kom ntseeg tau cov txiaj ntsig thiab kev ua haujlwm ntawmcorosolic acid. Peb cog lus tag nrho traceability los ntawm raw cov ntaub ntawv yuav khoom kom tiav cov khoom xa tuaj, muab cov khoom ruaj khov thiab kev pabcuam kev pabcuam los pab koj tsim kev tsim kho thiab kev lag luam nce qib.

Peb cov khoom zoo yog:

• Ua ntej,corosolic acidrho tawm los ntawmtxiv tsawb nploojthiab lwm yam nroj tsuag yog structurally thiab chemically zoo li nws cov isomer, crataegolic acid, ua rau kev sib cais nyuaj. Txawm li cas los xij, los ntawm kev ua kom zoo dua chromatographic sib cais thev naus laus zis thiab siab - cov txheej txheem ua kom huv huv, peb ua kom cov ntsiab lus ruaj khov ntawm lub hom phiaj tiv thaiv thiab tswj tsis tau, txo cov isomer residues.
• Thib ob, cov khoom lag luam nthuav tawm cov xim xim lossis cov tshuaj fluorescent nyob rau hauv cov dej tsis muaj dej, ua kom yooj yim rau kev txheeb xyuas qhov zoo thiab qhov kawg - thov kev txhim kho.
• Thib peb, peb nruj me ntsis tswj cov kuab tshuaj residues thiab microbiological ntsuas, xyuas kom peb cov khoom ua tau raws li thoob ntiaj teb cov zaub mov thiab cov khoom noj qab haus huv cov qauv raw khoom.