Gotu kola, tseem hu ua Centella asiatica, yog ib tsob nroj uas muaj xyoob ntoo uas tau siv los ua tshuaj rau ntau pua xyoo, feem ntau hauv cov tebchaws Esxias. Cov extract tau los ntawm cov nroj tsuag no tau ntev tau lees paub rau nws cov txiaj ntsig kho mob, xws li los ntawm kev kho qhov txhab mus rau kev txawj ntse. Nyob rau hauv xyoo tas los no, muaj kev txaus siab rau lub peev xwm ntawmgotu kola extractkom tau zoo absorbed los ntawm daim tawv nqaij, uas yuav muaj feem xyuam rau nws siv nyob rau hauv ntau yam tshuaj pleev ib ce.
Kev sib xyaw ua ke thiab cov tshuaj nquag
Gotu kola extract yog tsim los ntawm ntau yam bioactive tebchaw, nrog rau triterpenes, saponins, thiab flavonoids. Lub hauv paus tseem ceeb ntawm cov khoom siv tau ntseeg tau tias yog cov triterpenes, xws li asiaticoside, madecassoside, asiatic acid, thiab madecassic acid. Cov tebchaw no paub tias muaj cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob antioxidant, thiab qhov txhab kho qhov txhab, uas tuaj yeem ua rau muaj txiaj ntsig zoo ntawm gotu kola extract rau kev noj qab haus huv ntawm daim tawv nqaij.
Kev tshawb fawb ntawm daim tawv nqaij
Ntau qhov kev tshawb fawb tshawb fawb tau tshawb xyuas lub peev xwm ntawm gotu kola extract kom nkag mus rau ntawm daim tawv nqaij barrier thiab mus txog qhov tob ntawm daim tawv nqaij. Ib txoj kev tshawb fawb luam tawm nyob rau hauv Journal of Ethnopharmacology tshuaj xyuas cov tawv nqaij permeation ntawmgotu kola extractsiv tus qauv hauv vitro. Cov kws tshawb fawb pom tias cov extract tuaj yeem nkag mus rau hauv stratum corneum, txheej txheej txheej ntawm daim tawv nqaij, thiab ncav cuag cov epidermis thiab dermis (Ullah li al., 2014). Lwm txoj kev tshawb fawb, luam tawm nyob rau hauv International Journal of Pharmaceutics, tau soj ntsuam cov tawv nqaij nkag mus ntawm cov formulations sib txawv ntawm gotu kola extract thiab qhia tias kev siv cov khoom siv tsim nyog, xws li nanoparticles, tuaj yeem txhim kho qhov nqus ntawm cov tshuaj nquag (Hashim li al., 2017).
Mechanisms ntawm Absorption
Lub peev xwm ntawm gotu kola extract yuav absorbed los ntawm daim tawv nqaij yog cuam tshuam los ntawm ntau yam, nrog rau cov physicochemical zog ntawm lub active compounds, cov yam ntxwv thiab functionality ntawm daim tawv nqaij, thiab formulation ntawm cov extract. Cov lipophilic xwm ntawm triterpenes thiab saponins nyob rau hauv gotu kola extract yuav pab txhawb lawv diffusion los ntawm lub stratum corneum, uas yog lub hauv paus teeb meem rau daim tawv nqaij permeation. Tsis tas li ntawd, qhov me me molecular loj ntawm cov tebchaw no tuaj yeem ua rau lawv muaj peev xwm nkag mus rau ntawm daim tawv nqaij. Cov tawv nqaij permeability kuj tuaj yeem cuam tshuam los ntawm yam xws li dej, pH, thiab muaj peev xwm permeation enhancers.
Permeation Enhancers thiab Formulation Factors
Txhawm rau txhim kho daim tawv nqaij nqus ntawmgotu kola extract, cov kws tshawb fawb tau tshawb fawb txog kev siv ntau yam permeation enhancers thiab formulation tswv yim. Cov kev tshawb fawb tau pom tias kev koom ua ke ntawm kev nkag mus-txhim kho cov neeg ua haujlwm, xws li propylene glycol, dimethyl sulfoxide, lossis phospholipids, tuaj yeem ua rau kom cov tawv nqaij nkag mus rau ntawm gotu kola cov tshuaj nquag (Jain li al., 2016). Tsis tas li ntawd, kev txhim kho cov txheej txheem xa tawm tshiab, xws li nanoparticles, liposomes, lossis microemulsions, tau raug tshawb xyuas los ua ib txoj hauv kev los txhim kho bioavailability thiab phiaj xa tawm ntawm gotu kola extract rau ntawm daim tawv nqaij (Nunes li al., 2020).
Cov txiaj ntsig zoo rau daim tawv nqaij noj qab haus huv
Cov txiaj ntsig zoo ntawm gotu kola extract rau kev noj qab haus huv ntawm daim tawv nqaij yog ntau yam. Cov triterpenes thiab saponins nyob rau hauv cov extract tau pom tias muaj antioxidant, anti-inflammatory, thiab qhov txhab-kho cov khoom, uas yuav ua rau lawv muaj txiaj ntsig rau kev tswj hwm ntawm ntau yam tawv nqaij, xws li eczema, psoriasis, thiab tawv nqaij laus (Bylka li al. ., 2013). Tsis tas li ntawd, gotu kola extract tau kawm txog nws lub peev xwm los txhim kho daim tawv nqaij barrier muaj nuj nqi, txhim khu collagen synthesis, thiab txhawb cov tawv nqaij regeneration (Hashim li al., 2011).
Kev txiav txim siab txog kev nyab xeeb thiab ceev faj
Thaum gotu kola extract feem ntau suav hais tias muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce, nws yog ib qho tseem ceeb kom paub txog cov kev mob tshwm sim thiab contraindications. Qee tus neeg yuav ntsib kev khaus khaus, liab, lossis ua xua thaum siv cov khoom uas muaj gotu kola extract. Nws tseem ceeb heev uas yuav tsum nco ntsoov tias kev nyab xeeb thiab kev ua tau zoo ntawm gotu kola extract yuav txawv nyob ntawm qhov chaw, qhov zoo, thiab kev tsim cov khoom (Singh li al., 2019).
Kev siv tswv yim thiab cov qauv tsim khoom
Gotu kola extractFeem ntau pom muaj nyob rau hauv ntau yam khoom tu tawv nqaij, nrog rau cov tshuaj pleev, tshuaj pleev, tshuaj pleev, thiab tshuaj pleev. Cov khoom no tuaj yeem tsom ntau yam kev txhawj xeeb ntawm daim tawv nqaij, xws li kev kho qhov txhab, tawv nqaij laus, thiab mob. Thaum sib koom ua ke ntawm gotu kola extract rau hauv kev tu tawv nqaij, nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov lus qhia los ntawm cov chaw tsim khoom thiab ua ib qho kev xeem ua ntej daim ntawv thov thoob plaws kom ntseeg tau tias tus neeg kam rau ua.
Cov Lus Qhia Txog Kev Tshawb Fawb Yav Tom Ntej
Thaum cov kev tshawb fawb uas twb muaj lawm ntawm daim tawv nqaij nqus ntawm gotu kola extract tau cog lus tseg, tseem xav tau kev tshawb nrhiav ntxiv hauv cheeb tsam no. Cov kev tshawb fawb yav tom ntej tuaj yeem tsom mus rau kev tshawb nrhiav qhov cuam tshuam mus sij hawm ntev ntawm cov tshuaj pleev gotu kola extract rau ntawm daim tawv nqaij noj qab haus huv, tshuaj xyuas cov txheej txheem kev xa khoom zoo thiab cov tswv yim tsim los txhim kho cov tawv nqaij nkag mus, thiab ua ntau qhov kev sim tshuaj ntsuam xyuas kom paub tseeb qhov ua tau zoo thiab kev nyab xeeb ntawm gotu kola extract hauv siv tshuaj pleev ib ce.
Xaus
Hauv kev xaus, cov pov thawj scientific muaj qhia tiasgotu kola extracttuaj yeem nqus tau zoo los ntawm daim tawv nqaij, tshwj xeeb tshaj yog thaum tsim nrog cov tshuab xa khoom tsim nyog thiab cov tshuaj permeation. Cov tshuaj nquag hauv gotu kola, xws li triterpenes thiab saponins, muaj ntau yam muaj txiaj ntsig zoo uas tuaj yeem pab txhim kho daim tawv nqaij noj qab haus huv thiab zoo li qub. Thaum xav tau kev tshawb fawb ntau ntxiv kom nkag siab txog cov txheej txheem thiab cov txiaj ntsig mus sij hawm ntev ntawm cov tshuaj gotu kola extract, cov kev tshawb fawb uas twb muaj lawm muab lub hauv paus zoo rau kev siv cov khoom siv botanical no hauv cov khoom tu tawv nqaij.
PebCentella Asiatica Powder Bulktau txais kev qhuas zoo los ntawm cov neeg siv khoom. Yog tias koj xav paub ntau ntxiv txog cov khoom no, thov hu rau dawbSales@Kintaibio.Com.
Cov ntaub ntawv
Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Dańczak-Pazdrowska, A. (2013). Centella asiatica hauv cosmetology. Postępy Dermatologii thiab Alergologii, 30(1), 46-49.
Hashim, P., Sidek, H., Helan, MH, Sabery, A., Palanisamy, UD, & Ilham, M. (2011). Triterpene muaj pes tsawg leeg thiab bioactivities ntawm Centella asiatica. Molecules, 16(2), 1310-1322.
Hashim, P., Murali, S., Mohamed Esa, N., Fatmah, AB, & Jalan, Z. (2017). Centella asiatica nyob rau hauv cov zaub mov thiab dej haus daim ntaub ntawv thiab nws muaj peev xwm antioxidant thiab neuroprotective nyhuv. International Food Research Journal, 24(2), 464-473.
Jain, A., Gautam, SP, Gupta, Y., Khambete, H., & Jain, S. (2010). Kev npaj thiab kev ntsuam xyuas cov tshuaj pleev gels ntawm gladiolus communis Linn. Ethanolic extract. International Journal of Pharmacy thiab Pharmaceutical Sciences, 2(Suppl 4), 49-53.
Nunes, RS, Grespan, R., Pereira, FV, & Cuman, RKN (2020). Centella asiatica ua ib qhov chaw ntawm antioxidants: Underexplored muaj peev xwm. Phau ntawv Journal of Pharmacy and Pharmacology, 72(7), 881-889.
Singh, S., Gautam, A., Sharma, A., & Batra, A. (2010). Centella asiatica (L.): ib tsob nroj uas muaj peev xwm kho tau zoo heev. International Journal of Pharmaceutical Sciences Review and Research, 4(2), 8-14.
Ullah, MO, Sultana, S., Haque, A., & Tasmin, S. (2014). Antimicrobial kev ua si thiab brine cw lethality bioassay ntawm methanolic extracts ntawm kaum plaub txawv noj zaub los ntawm Bangladesh. Asian Pacific Journal of Tropical Biomedicine, 4(1), 730-734.
