Cytisinicline hmoovyog lub ntuj alkaloid rho tawm los ntawm legumes xws liThermopsis LanceolatathiabSophora Alopecuroides, thiab tau siv los ua cov tshuaj noj haus luam yeeb hauv Eastern Europe tau ntau xyoo lawm. Nyob rau hauv xyoo tas los no, nrog rau hauv - kev tshawb fawb tob txog lub luag haujlwm ntawm nicotinic acetylcholine receptors hauv kev tswj kev xav,cytisine, raws li ib feem ntawm agonist ntawm 4 2 nicotinic receptors, tau txais kev saib xyuas dav dav rau nws cov peev xwm hauv kev kho kev nyuaj siab. Tsab ntawv xov xwm no yuav tshuaj xyuas cov ntaub ntawv ntsig txog ntawmcytisine kev nyuaj siab.
KINTAIBIO®yog tus kws tshaj lijneeg tsim khoomntawmcytisine hmoov.Yog xav paub ntxiv txog cov khoom lag luam, thov hu rau peb:sales@kintaibio.com.
Kev tshawb fawb niaj hnub ntawm Cov Tshuaj Tiv Thaiv Kev Nyuaj Siab ntawm Cytisine
Cytisine muaj ntau yam teebmeem tshuaj, suav nrog kev haus luam yeeb, txhim kho myocardial contractility, txhim kho kev txawj ntse, tiv thaiv kev nyuaj siab, thiab kev tiv thaiv kab mob. Raws li qhov siab -affinity ib nrab agonist ntawm 4 2 nicotinic acetylcholine receptors (nAChRs),Sparteine hmoovtau pib paub txog nws cov teebmeem kev haus luam yeeb.
Txawm li cas los xij, kev tshawb fawb tshuaj niaj hnub no tau pom tias cytisine tsis yog tsuas yog kev pab tshem tawm kev haus luam yeeb xwb, tab sis kuj qhia tau tias muaj peev xwm nyob hauv thaj chaw neuropsychiatric, tshwj xeeb hauv kev kho kev nyuaj siab. Kev tshawb fawb tshawb fawb qhia tau hais tias "kev thaiv tsis yog kev ua kom" nicotinic receptors uas muaj 2 subunit tuaj yeem tsim cov nyhuv antidepressant. Qhov kev tshawb pom no muab lub hauv paus theoretical rau kev siv ntawmSophora Alopecuroides Extract Cytisinehauv kev kho mob hlwb.
cytisine mechanism ntawm kev txiav txim rau Antidepressant teebmeem
Neuronal Nicotinic Acetylcholine Receptors
Cytisinicline yog ib tug siab -affinity ib nrab agonist ntawm 4 2 nAChRs, thiab tseem muaj tag nrho cov agonist kev ua ub no tiv thaiv receptors uas muaj 4 subunit thiab 7 receptors. Cov kev tshawb fawb tau pom tias thaiv nAChRs uas muaj 2 subunit tuaj yeem tsim cov tshuaj tiv thaiv kev nyuaj siab -zoo li cov nyhuv. Cytisine ua tiav kev ua haujlwm antagonism los ntawm kev sib tw khi rau nicotine receptors, tab sis vim nws qhov kev ua haujlwm qis, nws txo qis kev ua haujlwm. Qhov no mechanism tso caiThermopsis Lanceolata Extract cytisinetxhawm rau tswj cholinergic signaling thaum tsis txhob muaj qhov cuam tshuam tsis zoo uas yuav tshwm sim los ntawm kev ua kom receptor ntau dhau.
Qhov chaw:https://www.sciencedirect.com
Neuroprotective thiab Neurotrophic Effects
Cov kev tshawb fawb preclinical tau pom tiasspartine sulfatetuaj yeem thim rov qab kev nyuaj siab -zoo li kev coj cwj pwm uas tshwm sim los ntawm kev nyuaj siab me me (UCMS). Cov kev tshawb fawb tseem ceeb ntawm cov txheej txheem molecular tau qhia tias cytisine tuaj yeem thim rov qab qhov poob qis hauv 5-HT1A receptor, hlwb-derived neurotrophic factor (BDNF), thiab mTOR theem hauv hippocampus thiab amygdala. Cov proteins no zoo sib xws rau neural plasticity thiab synaptic muaj nuj nqi, qhia tiasSophora Alopecuroides Extract Cytisine Powdertuaj yeem siv nws cov tshuaj tiv thaiv kev nyuaj siab los ntawm kev kho kev ntxhov siab- ua rau muaj kev puas tsuaj rau neuronal.
Tsiaj Model Validation: Breakthrough in Preclinical Research
Nyob rau hauv qhov kev ntsuam xyuas tus Tsov tus tw (TST), yuam kev ua luam dej (FST), thiab tus qauv kev ntxhov siab ntev (UCMS), cytisine nthuav tawm koob tshuaj -dependent antidepressant- zoo li cov teebmeem, txo cov sij hawm tsis muaj zog. c-fos qhia kev tsom xam qhia tiasSparteine hmoovtuaj yeem txo cov kev ua haujlwm neuronal hauv basolateral amygdala, uas tej zaum yuav cuam tshuam rau nws txoj kev xav - tswj cov teebmeem.
Qhov zoo ntawm Cytisine's Antidepressant Effects
Cytisinicline hmoov, raws li ib qho kev haus luam yeeb qub, muaj qhov zoo -cov ntaub ntawv kev nyab xeeb thiab ntau xyoo ntawm kev siv tshuaj kho mob. Piv nrog rau lwm cov tshuaj tiv thaiv kev ntxhov siab, cytisine muaj cov txiaj ntsig zoo hauv qab no:
- Novel mechanism ntawm kev txiav txim:Los ntawm kev hloov kho nicotinic receptor system, nws muaj kev xaiv tshiab rau cov neeg mob uas tsis teb zoo rau cov tshuaj SSRIs.
- Muaj peev xwm sai pib qhov kev txiav txim:Cov kev tshawb fawb tsiaj pom tias muaj txiaj ntsig zoo tuaj yeem pom hauv ob lub lis piam.
- Tus nqi -effectiveness:Mature extraction technology thiab kuj tsis tshua muaj nqi ntau lawm.
Vim li cas qhov purity ntawm cytisine tseem ceeb heev?
Kev tshawb fawb txog kev tshawb fawb thiab kev txhim kho kev kho mob muaj qhov xav tau siab heev rau qhov purity thiab impurity profile ntawm cov khoom xyaw tshuaj nquag. Raws li cov chaw tsim khoom,KINTAIBIO®nruj me ntsis raucGMPcov qauv, muab siab -purity (98%), low-hnyav-hlau-residuecytisine hmoovlos xyuas kom meej lub reproducibility thiab kev nyab xeeb ntawm kev sim cov ntaub ntawv. Peb lub siab -purity cytisine hmoov muaj cov txiaj ntsig hauv qab no:
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- High purity:Ib qho kev tswj xyuas nruj nruj ua kom cov khoom huv huv raws li kev tshawb fawb thiab kev thov.
- Tsawg impurities:Clear impurity profile tsom xam ua kom muaj kev rov tsim dua tshiab thiab kev ntseeg siab ntawm cov ntaub ntawv sim.
- Stable khoom:Los ntawm cov nroj tsuag rho tawm mus rau cov khoom tiav, peb tswj tag nrho cov saw hlau, lav qhov ntev - cov khoom ruaj khov rau kev tshawb fawb thiab kev tsim kho cov haujlwm.
Qhov twg yuav Cytisine zog?
Thermopsis Lanceolata Extract Cytisine, ib qho tshuaj tiv thaiv kev haus luam yeeb thaum ub, tab tom rov kho dua los ntawm kev tshawb fawb niaj hnub no. Nws lub peev xwm nyob rau hauv kev kho mob ntawm kev nyuaj siab yog raws li lub hom phiaj biology thiab accumulating soj ntsuam pov thawj.
KINTAIBIO®, raws li raw khoomCytisine Power Supplier, tos ntsoov rau kev koom tes nrog cov tuam txhab tsim kho tshiab los ua kom cov qib qis no - tus nqi qis, zoo - tau txhais cov molecule mus rau pem hauv ntej ntawm kev kho mob hlwb. Peb tau cog lus los muab cov khoom siv raw zoo sib xws rau peb cov neeg siv khoom thoob ntiaj teb, ua tau raws li koj cov kev xav tau sib txawv ntawm ntau qhov chaw. Thov hu rau peb ntawmsales@kintaibio.comkom paub meej cov khoom lag luam thiab kev txiav txim ntau ntxiv txogCytisine Hwj chim muag.
