Cytisine yog lub ntuj alkaloid muab los ntawm cov nroj tsuag leguminous (xws liThermopsis LanceolatathiabSophora alopecuroides). Vim nws tus nqi qis thiab kev kam rau siab zoo, nws tau txais kev saib xyuas ntau ntxiv nyob rau hauv daim ntawv ntawm cov tshuaj tua kab mob. Hauv kev siv tshuaj kho mob hauv ntau lub teb chaws ntau xyoo, tsis muaj cov ntaub ntawv qhia txog kev quav tshuaj, uas qhia tau tias muaj kev nyab xeeb zoo. Cov lus nug tseem ceeb hais txog nws txoj kev ua tau zoo "Cytisine Ua Haujlwm Li Cas?" nyob hauv nws cov tshuaj pharmacological tshwj xeeb.
Thaum lub Cuaj Hlis 2025, Daim Ntawv Thov Tshuaj Tshiab (NDA) rau Cytisinicline tau txais los ntawm US FDA, thiab kev pom zoo yuav tsum nyob rau lub Rau Hli 2026. Qhov no qhia tau hais tias cov molecule classic no tau txais kev lees paub los ntawm cov koom haum tseem ceeb thoob ntiaj teb. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cytisine tseem tsis tau pom zoo rau kev txiav txim siab haus luam yeeb hauv qee lub tebchaws thiab cheeb tsam; nws siv yuav tsum nyob rau hauv kev taw qhia ntawm ib tug kws kho mob.
Raws li ib tug kws manufacturers ntawmsparteine sulfateraw khoom,KINTAIBIO®tau cog lus los muab cov neeg siv khoom nrog siab -purity (99%HPLC)cytisine hmoov. Rau kev yuav khoom nug, thov hu rau peb ntawmsales@kintaibio.com.
Cytisine Mechanism of Action: Rau Kev Haus Luam Yeeb
Cytisine yog ib feem agonist ntawm nicotinic acetylcholine receptor, nrog nws lub hom phiaj tseem ceeb yog 4 2 nicotinic acetylcholine receptor (nAChR) nyob rau hauv nruab nrab paj hlwb. Qhov no receptor subtype ua lub luag haujlwm tseem ceeb hauv lub hlwb txoj hauv kev muab nqi zog: thaum nicotine khi rau nws, nws ua rau cov receptor thiab txhawb kev tso tawm dopamine, ua rau muaj kev txaus siab thiab txhawb zog, thaum kawg ua rau kev quav yeeb quav tshuaj.Cytisiniclineexerts dual pharmacological nyhuv los ntawm kev khi rau tib receptor:
Ib Feem Agonist Effect: Txo cov tsos mob ntawm kev rho tawm
Cytisine muaj kev sib raug zoo siab rau 4 2 receptor tab sis tsis tshua muaj kev ua haujlwm. Qhov no txhais tau tias nws tuaj yeem khi nruj rau cov receptor, tab sis nws lub peev xwm los qhib lub receptor yog tsawg dua li ntawm nicotine. Cov kev tshawb fawb tau qhia tiasThermopsis Lanceolata Extract cytisine's activation efficiency ntawm 4 2 receptor yog li ntawm 15% ntawm tag nrho cov agonist, ua rau ib tug nruab nrab dopamine tso.
Thaum cov neeg haus luam yeeb nres nres nicotine, qib dopamine hauv lub hlwb poob qis, ua rau cov tsos mob tshem tawm xws li kev ntxhov siab, ntxhov siab, tsis zoo, thiab insomnia. Cytisinicline, los ntawm ib feem ua rau 4 2 receptors, tswj cov qib dopamine nruab nrab, yog li ua kom cov tsos mob tshem tawm thiab pab cov neeg haus luam yeeb los ntawm lub sijhawm pib tsis xis nyob ntawm kev tshem tawm.
Qhov chaw:https://www.sciencedirect.com
Competitive antagonism: Txo Nicotine Cravings
Vim nws muaj kev sib raug zoo heev rau 4 2 receptors, cytisine tuaj yeem tuav cov nicotine khi qhov chaw ntawm cov receptors, tsim kev sib tw thaiv. Thaum cov neeg haus luam yeeb raug luam yeeb dua thaum noj cov tshuaj, nicotine tsis tuaj yeem khi zoo rau cov receptors tam sim no nyob los ntawm Thermopsis Lanceolata Extract, yog li ua rau tsis muaj zog ntawm cov txiaj ntsig ntawm nicotine. Txawm hais tias cov neeg haus luam yeeb haus luam yeeb, lawv tsis tuaj yeem tau txais qhov kev zoo siab qub, yog li maj mam txo lawv txoj kev xav ntawm lub hlwb thiab kev vam khom ntawm nicotine.
Qhov no ob lub tswv yim- ua kom ib nrab los txo qis kev tshem tawm + kev sib tw antagonism los thaiv cov nqi zog- ua lub hauv paus tshuaj ntawm cytisine txoj kev haus luam yeeb.
Qhov chaw:https://www.sciencedirect.com
Puas yog Cytisine Safe?
Ntau qhov kev sib tw tswj hwm thiab meta- kev tshuaj xyuas tau lees paub qhov ua tau zoo ntawmcytisinehauv kev haus luam yeeb:
- Piv rau cov placebo:cytisine txhim kho qhov kev haus luam yeeb ua tiav ntawm kwv yees li 2.65 zaug;
- Piv rau nicotine hloov kho:Cytisinicline qhia tau hais tias zoo dua 6-hli kev noj qab haus huv tus nqi (54.1% vs 31.2%);
- Piv rau varenicline:cytisine muaj qhov zoo sib xws ntawm kev haus luam yeeb haus luam yeeb tab sis tsis tshua kim thiab tej zaum yuav muaj kev cuam tshuam tsis zoo neuropsychiatric (xws li lub siab hloov pauv thiab pw tsaug zog tsis zoo).
Cytisine feem ntau zoo - zam. Cov kev mob tshwm sim ntawmsparteine sulfatesuav nrog kev mob plab me me (xws li xeev siab thiab mob plab) thiab pw tsaug zog cuam tshuam, uas feem ntau tsis muaj sijhawm thiab tsis xav tau kev kho mob tshwj xeeb. Tsis muaj qhov tshwm sim tsis zoo tshwm sim hauv cov kev tshawb fawb uas twb muaj lawm.
Qhov twg yuav cytisine hmoov?
Pebcytisine hmoovua haujlwm los ntawm ib nrab ua kom cov 4 2 nicotine receptor, tshem tawm cov tsos mob thiab thaiv cov nqi zog ntawm nicotine. Nws yog ib qho kev pab tshem tawm kev haus luam yeeb nrog lub qhov dej -txhais tau hais tseg thiab ua pov thawj ua tau zoo. Ntau cov ntaub ntawv pov thawj qhia tiasSparteine Sulfate cytisine hmoovyog ib qho kev cuam tshuam zoo tshaj plaws los pab tib neeg txiav luam yeeb.
Raws li cov chaw tsim khoom ntawm siab -puritySophora Alopecuroides Extract cytisineraw khoom,KINTAIBIO®nruj me ntsis ua raws li Kev Tswj Xyuas Zoo (GMP) cov cai, muab cov khoom lag luam ruaj khov thiab cov khoom sib xws - zoo ib yam, pab rau kev tshawb fawb thiab kev tsim kho thiab tsim cov kev npaj haus luam yeeb thoob ntiaj teb. Yog xav paub ntxiv txog kev paub lossis kev yuav khoom nug, thov hu rau:sales@kintaibio.com.
