Kev haus luam yeeb tau raug lees paub los ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv (World Health Organization) tias yog kab mob sib kis, nrog rau nicotine yog thawj tus neeg ua txhaum. cytisine tuaj yeem pab txo kev haus luam yeeb los ntawm kev sib tw inhibiting nicotine khi rau receptors, txo cov nqi zog thiab tshem tawm cov tsos mob ntawm nicotine. Txawm li cas los xij, rau txhua yam kev puas siab puas ntsws, kev quav yeeb quav tshuaj yog ib qho kev txhawj xeeb tshaj plaws rau pej xeem.
Raws li cov nroj tsuag alkaloid,Sparteine sulfate cytisinetam sim no tsis muaj pov thawj ntawm kev quav yeeb quav tshuaj. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias nws tseem tsis tau pom zoo rau kev txiav txim siab haus luam yeeb hauv qee lub tebchaws thiab cheeb tsam, thiab nws yuav tsum siv raws li kev qhia ntawm tus kws kho mob. Kab lus no yuav tshawb txog qhov tob yog vim li casSophora Alopecuroides Extract Cytisinetsis muaj kev quav yeeb quav tshuaj, nws txoj kev nyab xeeb thiab kev ua tau zoo, thiab yog vim li cas nws thiaj li cog lus tias yog ib qho kev xaiv tseem ceeb rau kev kho kev haus luam yeeb yav tom ntej.
KINTAIBIO®, raws li ib tug kws tsim khoom, muab99%dawb huvcytisine hmoovua nruj me ntsis raws li kev tswj hwm thoob ntiaj teb cov qauv, kom ntseeg tau meej npaum li cas thiab tswj tau impurities. Thov hu rau peb ntawmsales@kintaibio.comyog xav tau.
cytisine mechanism ntawm kev txiav txim - Yog vim li cas cytisine tsis quav ntsej?
Cytisinicline, ib tsob nroj alkaloid, muaj kev sib raug zoo rau 4 2 nicotine acetylcholine receptor nyob rau hauv lub hlwb. Nws ua raws li ib feem agonist. Qhov no txhais tau tias nws ua rau tib receptors zoo li nicotine, tab sis nrog cov teebmeem sib txawv. Thaum tus neeg haus luam yeeb siv cytisine, nws khi preemptively rau cov receptors, tuav nicotine qhov chaw. Qhov no txwv tsis pub nqus nicotine los ntawm kev khi rau cov receptors, yog li thaiv kev txaus siab thiab nqi zog ntawm kev haus luam yeeb.
Qhov chaw:https://www.sciencedirect.com
Raws li ib feem ntawm agonist,Cytisinicline, thaum tuav cov receptors, ua rau me me, txhawb nqa kev txhawb nqa, tso tawm ib nrab ntawm dopamine. Qhov no yog qhov txaus los txo cov nicotine cravings thiab tshem tawm cov tsos mob xws li kev ntxhov siab thiab kev chim siab, tab sis deb ntawm qhov siab tshaj ntawm nicotine. Yog li ntawd, nws muab kev txhawb siab kev xav yam tsis ua rau muaj kev mob siab rau lub voj voog ntawm nicotine.
Cytisine muaj kev nyab xeeb?
Ntau qhov kev tshawb fawb niaj hnub no tau pom tias cytisine yog ib qho kev nyab xeeb thiab siv tau zoo rau kev haus luam yeeb. Nws cov kev mob tshwm sim (xws li mob plab thiab pw tsaug zog cuam tshuam) zoo ib yam li varenicline, tab sis nrog qhov tshwm sim qis dua. Tsis tas li ntawd,Cytisinicline hmoovtsis tshua kim los tsim, ua rau nws pheej yig dua li varenicline thiab nicotine hloov kho.
Kev tshuaj xyuas zoo suav nrog 12 qhov kev sim tshuaj ntsuam xyuas tau pom tias cytisine muaj kev nyab xeeb zoo.profile, tsis muaj pov thawj ntawm teeb meem kev nyab xeeb loj. Tsis muaj qhov sib txawv tseem ceeb hauv cov naj npawb ntawm cov xwm txheej tsis zoo ntawm covSparteine sulfate cytisinepab pawg thiab cov placebo pawg (kev phom sij piv=1.19, 95% kev ntseeg siab lub sijhawm=0.99-1.41; 6 kev sim; 4578 tus neeg koom).
Common Adverse Events (Mild thiab Transient):
- Gastrointestinal Reactions:Nausea, Indigestion, Hloov saj, Qhov ncauj qhuav, Txo qab los noj mov
- Nervous System Reactions:Mob taub hau, npau suav phem, pw tsis tsaug zog, chim siab
- Yam ntxwv:Feem ntau cov xwm txheej tsis zoo yog tus kheej - txwv thiab tsis tas yuav muaj kev kho tshwj xeeb.
Siv:https://pubmed.ncbi.nlm.nih.gov/38965792/
Puas yog cytisine lom?
Thaum tham txog kev nyab xeeb ntawm cytisine, lub ntsiab lus ntawm "kev lom" inevitably tuaj. Ntawm no, qhov sib txawv tseem ceeb yuav tsum tau qhia meej: qhov sib txawv ntawm cov nroj tsuag lom thiab tshuaj overdose.
Cov kab mob lom tshwm sim los ntawm cov noob cog
Cytisine yog ib txwm pom nyob rau hauv cov noob ntawm leguminous nroj tsuag (Thermopsis Lanceolata, Sophora Alopecuroides). Kev noj cov noob ntau ntawm qee cov nroj tsuag tuaj yeem ua rau muaj tshuaj lom (xws li xeev siab, ntuav, raws plab, tsaug zog, qaug zog, leeg twitching, thiab lwm yam), uas yog vim li cas qee qhov kev tshaj tawm ntawm "cov tub ntxhais kawm tsis siv cov noob cog thiab ua tshuaj lom" tau tshwm sim. Txawm li cas los xij, cov ntaub ntawv tshaj tawm no tau tshwm sim los ntawm kev nqos cov noob ncaj qha, tsis yog los ntawm kev noj cov khoom huv, siab -puritySophora Alopecuroides Extract Cytisine hmoov. Cov khoom ntawm cov nroj tsuag ntuj yog complex thiab tej zaum yuav muaj lwm yam tshuaj lom (xws li cyanide), thiab cov ntsiab lus yog uncontrolled.
Kev nyab xeeb npaum li cas cytisine hauv kev siv tshuaj kho mob?
Ib daim ntawv tshaj tawm tau tshaj tawm nyob rau hauvPhau ntawv Journal of Medical Case Reportshauv 2024: Ib tug poj niam muaj hnub nyoog 64 xyoo, vim tsis nkag siab txog cov lus qhia tshuaj, tau noj ob zaug ntawm cov tshuaj pom zoo ib hnub rau yim hnub sib law liag, ua rau kom noj 54 mg / hnub ntawm cytisine rau peb hnub sib law liag. Txawm hais tias koob tshuaj nyob deb tshaj li tus qauv, tus neeg mob tsis tau tshaj tawm cov kev phiv tshwm sim. Cov ntaub ntawv no lees paub tiascytisine hmoovmuaj kev ruaj ntseg profile txawm nyob rau hauv cov koob tshuaj ntau.
Siv:https://pubmed.ncbi.nlm.nih.gov/39614385/
Qhov twg yuav Cytisine?
Hauv cov ntsiab lus,cytisine hmoovnws tus kheej tsis ua rau muaj kev quav tshuaj lossis lom. Nws muaj qhov zoo ntawm kev ua tau zoo, kev nyab xeeb siab, thiab tus nqi qis, ua rau nws yog ib qho cuab yeej zoo los pab cov neeg haus luam yeeb tawm ntawm nicotine dependence. Txawm li cas los xij, nws yog ib qho tseem ceeb kom paub meej qhov ntawdsparteine sulfate cytisine hmoovyuav tsum tau siv raws li kev qhia ntawm tus kws kho mob. Nws qhov "induction" dosing regimen (maj mam nce koob tshuaj thaum txo kev haus luam yeeb) yog qhov tseem ceeb rau kev ua kom muaj txiaj ntsig thiab kev nyab xeeb.
KINTAIBIO®nruj me ntsis xaiv thiab kuaj cov ntaub ntawv raw, saib xyuas tag nrho cov txheej txheem tsim khoom, thiab ua ntau yam kev ntsuam xyuas ntawm qhov tiavCytisinicline hmoov, suav nrog cov ntsiab lus active ingredient, ziab poob, cov ntsiab lus tshauv, hnyav hlau, thiab cov kab mob. Nws ua raws li kev tswj hwm nruj xws li ISO thiab GMP cov qauv kom paub meej cov khoom zoo thiab kev nyab xeeb.
Peb cov khoom ua tiav purity txog li 99% Sophora Alopecuroides Extract Cytisinehmoov, kom ntseeg tau nws cov ntawv thov dav hauv kev lag luam tshuaj thiab kev noj qab haus huv ntxiv. Ntau yam khoom tshwj xeeb muaj, los ntawm cov pob me me tsim nyog rau kev tshawb fawb hauv chav kuaj mus rau cov pob khoom loj uas haum rau kev tsim khoom, kom tau raws li cov kev xav tau ntawm cov neeg siv khoom sib txawv.
