Senna, tseem hu ua laxative, lus Askiv lub npe FOLIUM SENNAE, yog ib qho stimulant laxative. Nws kis tau los ntawm txoj hnyuv mucosa thiab paj hlwb los txhawb peristalsis. Nws yog ib qho tshuaj muaj zog thiab pom zoo kom siv me ntsis. Ua rau ntawm txoj hnyuv, feem ntau hauv ob peb teev.
Taw qhia
Cov nplooj qhuav qhuav ntawm legume Senna senna. Lub sij hawm flowering yog lub Cuaj Hli mus txog Lub Kaum Ob Hlis, thiab lub sij hawm fruiting yog lub Peb Hlis ntawm xyoo tom ntej.
[Lawv]Qab zib, ntsim, txias. Rov qab mus rau txoj hnyuv loj meridian.
[Functions thiab Indications]Relieves cua sov thiab stagnation, tshem cov quav, thiab diureses dej. Rau cov cua sov stagnation, cem quav, mob plab, edema thiab fullness.
[Kev siv thiab ntau npaum li cas]2a6g ua.
[Nco tseg]Cov poj niam cev xeeb tub yuav tsum tau siv nrog ceev faj.
[Cia]Khaws kom deb ntawm lub teeb thiab qhov chaw nyob rau hauv qhov chaw ventilated thiab qhuav.
Cov yam ntxwv
Nplooj senna: ntev ovate los yog ovate-lanceolate, 1.5-5cm ntev, 0.4-2cm dav, tag nrho cov npoo, acutely pointed nplooj nplooj, me ntsis asymmetrical nplooj puag. Sab saum toj yog daj-ntsuab, sab saum toj yog lub teeb-daj-ntsuab, glabrous los yog ze li ntawm glabrous, nrog me ntsis tsa cov leeg. Tawv. Cov roj tsis muaj zog thiab tshwj xeeb, saj yog iab me ntsis, thiab nws yog me ntsis nplaum.
Senna acuminate: lanceolate los yog ntev oval, me ntsis curly, luv taw los yog me ntsis convex ntawm nplooj kawg, asymmetric nplooj hauv paus, thiab cov plaub hau luv ntawm ob sab.
Pharmacological kev ua
1. Cov nyhuv laxative Cov khoom no muaj cov nyhuv cathartic tseem ceeb rau cov nas, nas, luav thiab lwm yam tsiaj thiab tib neeg. Cov nas thiab luav ua rau raws plab 2-4 teev tom qab noj tshuaj, thiab tib neeg muaj raws plab li 6 teev tom qab noj qhov ncauj. . Cov khoom xyaw nquag ntawm cov khoom no feem ntau yog sennoside A thiab B, tshwj xeeb tshaj yog sennoside A. Txawm hais tias sennoside C muaj qhov ua rau mob raws plab zoo li A, nws cov ntsiab lus tsawg heev. Sennoside A 20mg / kg tuaj yeem ua rau mob raws plab hauv nas. Tab sis yog tias 20 feem pua C sib xyaw hauv A, cov nyhuv ntawm sennoside A tuaj yeem txhim kho los ntawm 1.6 npaug. Sennoside tuaj yeem nkag mus rau hauv cov hnyuv me me, thiab tom qab ntawd nkag mus rau hauv cov hnyuv loj los ntawm cov hlab ntsha lossis cov kua tsib, thiab feem ntau nkag mus rau hauv cov hnyuv loj ncaj qha los ntawm cov hnyuv me, thiab nkag mus rau hydrolysis thiab txo qis hauv kev ua ntawm cov kab mob hauv plab. -8-Glucoside. Txij li thaum cov nyhuv purgative ntawm kev txhaj tshuaj ncaj qha ntawm rhein anthrone tsis cuam tshuam, thiab kev tsim cov rhein anthrone hauv cov hnyuv tuaj yeem pom tias txo qis, nws ntseeg tau tias rhein anthrone yog cov khoom siv tiag tiag ntawm sennoside ua rau purgative. Ntawm qhov tod tes, sennoside tiv thaiv kev thauj mus los hauv plab hnyuv ntawm cov piam thaj thiab Na thaum lub sij hawm hloov pauv ntawm cov hnyuv thiab cov hnyuv, tawm tswv yim tias inhibition ntawm plab hnyuv nqus ntawm cov piam thaj, sodium, thiab dej nce lub ntim ntawm intraluminal uas ua rau lub plab hnyuv. reflexively Qhov txhim kho peristalsis ntawm txoj hnyuv me thiab txoj hnyuv kuj yog ib qho ntawm nws cov txheej txheem laxative, thiab cov hnyuv me kuj yog qhov chaw ua haujlwm ntawm nws cov tshuaj laxative.
2. Cov nyhuv Hemostatic Siv tau rau kev mob plab thiab duodenal los ntshav. Cov dej infusion tov ntawm cov khoom no yog txau rau ntawm lub plab los ntshav qhov chaw nyob rau hauv lub gastroscope, thiab nws muaj peev xwm tam sim ntawd tso tseg los ntshav thaum saib ncaj qha. Intraperitoneal txhaj ntawm tag nrho senna glycosides 200mg / kg tuaj yeem txo lub sijhawm los ntshav ntawm cov nas. Kev tswj hwm qhov ncauj ntawm senna tuaj yeem ua rau cov ntshav ntau ntxiv thiab cov ntsiab lus fibrinogen, thiab txo lub sij hawm coagulation, lub sij hawm thromboplastin, lub sij hawm recalcification plasma thiab lub sij hawm clot contraction. Tsis tas li ntawd, kev tiv thaiv ntawm cov khoom no ntawm kev raug mob plab hnyuv hauv cov nas uas tshwm sim los ntawm hydrochloric acid thiab indomethacin kuj tseem muaj txiaj ntsig zoo rau kev tiv thaiv thiab kho mob plab thiab duodenal los ntshav.
3. Antibacterial nyhuv Senna nplooj extract muaj inhibitory nyhuv ntawm ntau yam kab mob, xws li Escherichia coli, Proteus, Shigella, Streptococcus A, Candida albicans thiab ib co kab mob ntawm daim tawv nqaij fungi.
4. Lwm yam teebmeem Hauv cov nas uas muaj kev sim plab hnyuv infarction, kev txhaj tshuaj intraperitoneal ntawm sennoside 50 mg / kg tuaj yeem rov qab txo cov plab hnyuv mucosa histamine kom zoo li qub. Tsis tas li ntawd, nws tau raug tshaj tawm tias cov khoom no muaj cov txiaj ntsig zoo li curare, uas tuaj yeem thaiv kev sib kis ntawm cov hlab ntsha-cov leeg nqaij sib txuas impulses, tiv thaiv kev khi ntawm acetylcholine rau M receptors thiab ua rau cov leeg so.
5. Toxicity Lub LD50 ntawm tag nrho cov senna glucosides hauv nas los ntawm kev txhaj tshuaj intraperitoneal yog 1.414g / kg, uas sib npaug rau 36.3g / kg ntawm cov tshuaj crude.
