Part 1: General piav qhia
Birch bark extract betulinic acid(BetA) yog ib yam khoom ntuj feem ntau yog los ntawm tsob ntoo birch (Betula spp.). Qhov no pentacyclic lupanetype triterpenoid kuj muaj feem xyuam nrog lwm hom xws li Syzygium spp., Diospyros spp., Ziziphus spp, thiab Paeonia spp.
Nws kuj muaj kev ua haujlwm tiv thaiv kab mob, tiv thaiv kab mob npaws thiab ua haujlwm tiv thaiv kab mob. Tsis ntev los no, nws tau tshaj tawm tias nws muaj kev tiv thaiv kabmob kheesxaws los ntawm inhibiting topoisomerase. Nws tau pom thawj zaug hauv qee hom ntawm genus Betula, xws li Betula pubescens. Cov tawv ntoo ntawm tsob ntoo muaj npe tom qab nws.
Part 2: Daim ntawv thov
Birch bark extract betulinic acid (BetA) tau siv:
1.Kom kuaj nws cov teebmeem raws li tus neeg sawv cev tiv thaiv kab mob tiv thaiv tus kab mob Dengue (DENV)
2.Raws li sterol regulatory element-binding protein (SREBP) inhibitor los tswj cov lipid metabolism thiab kev loj hlob ntawm cov cell cell carcinoma (ccRCC) hlwb
3.Raws li kev kho mob los sim nws cov khoom tiv thaiv qog rau cov cell viability thiab apoptotic cell tuag kev soj ntsuam hauv ntau tus qauv myeloma
Part 3: Biochem/physiol Actions
Birch bark extract betulinic acid qhia ntau yam khoom lom thiab tshuaj xws li tshuaj tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv tib neeg kev tiv thaiv kab mob (HIV), thiab tiv thaiv kab mob malarial.
Birch bark extract betulinic acid, ib tug pentacyclic triterpene, xaiv induces apoptosis nyob rau hauv cov qog hlwb los ntawm ncaj qha activating lub mitochondrial txoj kev ntawm apoptosis los ntawm ap53- thiab CD95- ywj siab mechanism.
