Part 1: Pharmacological kev ua ntawm Aescigenin
Aescigenin muaj ntau yam kev ua haujlwm tshuaj, suav nrog kev tiv thaiv kab mob, tiv thaiv edema, txhim kho venous tone, inhibiting gastric acid secretion, scavenging reactive oxygen hom, thiab tawm tsam daim siab puas. Clinically, nws yog tam sim no tsuas yog siv nyob rau hauv kev kho mob ntawm venous insufficiency, cerebral edema, postoperative edema thiab raug mob. Nyob rau hauv xyoo tas los no, nws cov nyhuv los tiv thaiv qog tau maj mam nyiam cov neeg tshawb nrhiav, tab sis muaj qee cov ntaub ntawv ntsig txog, feem ntau yog nyob rau hauv vitro tshawb fawb theem. Nws kuj tau tshaj tawm tias aescin tsis tsuas yog muaj cov nyhuv ntawm cov qog nqaij hlav, tab sis kuj muaj cov nyhuv inhibiting qog metastasis.
Part 2: Cov qog nqaij hlav qog nqaij hlav cancer rau tib neeg noj qab haus huv
Cov qog nqaij hlav qog nqaij hlav cancer yog cov qog nqaij hlav loj tshaj plaws ntawm cov kab mob endocrine, suav txog ntau dua 90 feem pua ntawm cov qog qog nqaij hlav hauv cov qog endocrine. Qhov xwm txheej ntawm cov qog nqaij hlav qog noj ntshav tau nce thoob ntiaj teb, suav txog 2.5 feem pua ntawm tag nrho cov qog nqaij hlav hauv tib neeg.
Part 3: Kev ua tau zoo ntawm Aescigenin
Saponins yog ib pawg tseem ceeb ntawm cov khoom ntuj tsim hauv cov nroj tsuag. Aescin yog lub ntsiab active ingredient ntawm nees chestnut ntawm nees chestnut tsev neeg los yog cov tsoos suav tshuaj sorrel, thiab belongs rau triterpenoid saponins. Aescin sodium, tshuaj siv dav hauv kev kho mob, yog sodium ntsev compound ntawm aescin. Aescin muaj ntau yam tshuaj ua haujlwm, suav nrog kev tiv thaiv kab mob, tiv thaiv edema, txhim kho venous tone, inhibiting gastric acid secretion, scavenging reactive oxygen hom, thiab tawm tsam daim siab puas. Clinically, nws yog tam sim no tsuas yog siv nyob rau hauv kev kho mob ntawm venous insufficiency, cerebral edema, postoperative edema thiab raug mob.
Part 4: Thawj qhov kev tshawb fawb soj ntsuam ntawm escin hauv cov thyroid cancer
Kev tshawb fawb soj ntsuam tsis ntev los no los ntawm Anhui Medical University hauv 2017 tau qhia tias aescin muaj cov txiaj ntsig zoo rau cov qog nqaij hlav qog noj ntshav, thiab cov neeg mob tau pom zoo ua siab ntev. Qhov no yog thawj zaug hauv tsev thiab txawv teb chaws daim ntawv thov ntawm aescin hauv cov thyroid cancer. kev tshawb fawb soj ntsuam.
Part 5: Cov txheej txheem tshawb fawb soj ntsuam
Nyob rau hauv txoj kev tshawb no, 1120 cov neeg mob tau muab faib ua plaub pawg nyob rau nruab nrab, thiab lawv tau muab ib tug dawb paug reagent raws li kev tswj thiab sib txawv koob tshuaj ntawm aescin los soj ntsuam cov pharmacokinetics thiab cov kev phiv ntawm aescin. Tsis tas li ntawd, 2120 cov neeg mob qog nqaij hlav qog noj ntshav tom qab siv escin tau kuaj xyuas biomarkers cuam tshuam txog kev kis tus kab mob, thiab qhov kev vam meej tsis muaj sia nyob thiab kev ciaj sia tag nrho raug tshuaj xyuas thiab tshuaj xyuas. Cov tshuaj escin tau muab tso rau hauv txoj hlab ntshav rau 9 hnub ntawm 0.6 mg / kg ib hnub. koob tshuaj, kom lub plasma escin concentration tseem nyob tas li thaum lub sij hawm kho. Txhua tus neeg mob tau pom zoo ua siab ntev. Cov txiaj ntsig tau pom tias escin tuaj yeem txo cov ntsiab lus ntawm thyrotropin, thyroglobulin antibody, thyroglobulin thiab calcistatin hauv plasma, ua kom lub neej tsis muaj sia nyob ntev thiab ua kom muaj kev vam meej tsis muaj sia nyob ntawm cov neeg mob qog noj ntshav siab. kev ciaj sia tag nrho.
Ntu 6: Kev Tshawb Fawb Txog Kev Tshawb Fawb
Tsuas yog ob tus neeg mob hauv txoj kev tshawb fawb no tau ntsib cov kev mob tshwm sim, ib tus tsim mob ntshav qab zib thiab lwm tus tau nce alanine aminotransferase. Qhov kev sim no muab qee lub hauv paus rau kev siv escin hauv cov qog nqaij hlav qog noj ntshav, thiab cov kev tshawb fawb soj ntsuam txog kev ua tau zoo thiab kev nyab xeeb ntawm escin nrog cov koob tshuaj ntau dua thiab siv sijhawm ntev dua hauv cov neeg mob qog noj ntshav tseem xav tau.
