Coptis chinasis, tseem hu ua Suav goldthread, yog ib tsob nroj uas tau siv rau hauv tshuaj suav tshuaj (TCM) rau ntau tshaj 3,000 xyoo. Cov rhizomes thiab cov hauv paus hniav ntawm Coptis chinensis muaj berberine, ib qho isoquinoline alkaloid uas muab cov nroj tsuag nws cov xim daj. Keeb kwm, Coptis chinensis tau siv los kho cov mob inflammatory, kab mob, raws plab, thiab lwm yam teeb meem digestive. Kev tshawb fawb tsis ntev los no tau pom ntau lub teeb pom kev zoo ntawm cov cuab yeej muaj peev xwm thiab cov txiaj ntsig kev noj qab haus huv ntawm cov nroj tsuag tshuaj no.
Coptis Chinensis yog dab tsi?
Coptis chinensis yog ib tsob nroj uas tsis tshua loj hlob nyob rau hauv tsev neeg buttercup. Nws yog ib txwm nyob rau Suav teb nrog rau qee qhov chaw ntawm Asia xws li Nyab Laj, Nyiv thiab Himalayas. Nyob rau hauv cov qus, nws loj hlob nyob rau hauv lub roob ravines thiab shady wetlands. Coptis chinensis muaj cov rhizomes daj daj uas yog cov nroj tsuag tseem ceeb siv rau kev kho mob. Cov nplooj ntawm Coptis chinensis yog txuam nrog peb nplooj ntawv. Nws cov paj me me Bloom txij lub Tsib Hlis mus txog rau Lub Rau Hli.
Ntxiv rau berberine, Coptis chinensis muaj lwm cov tshuaj lom neeg lom neeg xws li palmatine, epiberberine, coptisine, columbamine, jatrorrhizine, magnoflorine, thiab ferulic acid. Muaj qee qhov kev hloov pauv hauv qhov ntau ntawm berberine, coptisine, palmatine thiab lwm yam alkaloids nyob ntawm thaj chaw loj hlob. Thaum Coptis chinensis los ntawm cov cheeb tsam sib txawv tuaj yeem muaj cov tshuaj pleev xim sib txawv me ntsis, berberine tseem yog cov khoom tseem ceeb hauv qab feem ntau cov teebmeem.
Kev siv tshuaj kho mob ntawm Coptis Chinensis
Nrog rau keeb kwm ntev ntawm kev siv hauv TCM thiab Ayurveda,Coptis chinensis extract hmoovtxuas ntxiv mus tshawb fawb rau cov kev siv kho mob niaj hnub no. Qee qhov kev siv tshuaj tseem ceeb suav nrog:
- Teeb meem digestive
Coptis chinensis ib txwm siv los kho txhua yam teeb meem digestive nrog rau raws plab, noj tshuaj lom, kab mob hauv plab, plab hnyuv, kab mob plab hnyuv xws li mob plab lossis kab mob Crohn. Ntau qhov kev tshawb fawb tam sim no tau lees paub qhov txiaj ntsig ntawm plab hnyuv ntawm Coptis chinensis ob qho tib si hauv cov qauv tsiaj thiab kev sim tib neeg. Cov berberine hauv Coptis chinensis extract tuaj yeem pab tshem tawm cov kab mob hauv plab, txo cov plab hnyuv los ntawm txoj hauv kev xws li NF-kB lossis COX-2 inhibition, txhim kho cov ntaub so ntswg rov ua dua thiab hloov cov plab hnyuv microflora.
- Mob ntshav qab zib
Kev tshawb fawb ntau hauv xyoo tas los no qhia tau tias Coptis chinensis tuaj yeem pab tswj cov ntshav qab zib hauv cov ntshav qab zib. Tib neeg kev sim ua kom pom tias berberine hauv Coptis chinensis pab txo hemoglobin A1c, yoo ntshav qabzib thiab ntshav qabzib hauv cov neeg mob ntshav qab zib. Berberine kuj tseem txhim kho insulin rhiab heev thiab pancreatic beta cell muaj nuj nqi. Cov txheej txheem muaj peev xwm tom qab cov tshuaj tiv thaiv kab mob ntshav qab zib no suav nrog kev txhawb nqa cov tshuaj insulin, txhim kho cov piam thaj hauv cellular los ntawm GLUT-1 thauj, ua kom txoj hauv kev AMPK, inhibiting gluconeogenesis hauv daim siab thiab cov leeg, thiab tswj cov lipid metabolism.
- Antimicrobial
Hauv kev siv ib txwm siv, Coptis chinensis tau siv tshuaj pleev los yog coj mus rau sab hauv los kho cov kab mob dav dav, kab mob, thiab cov kab mob ua rau cov kab mob ntawm daim tawv nqaij, kab mob ua pa, kab mob raws plab, lossis sepsis. Kev tshawb fawb niaj hnub no tau lees paub tias muaj cov tshuaj tua kab mob tiv thaiv kab mob xws li staphylococcus aureus, streptococcus pneumonia, escherichia coli, pseudomonas aeruginosa, salmonella, kab mob khaub thuas, aspergillus thiab candida albicans rau npe rau ob peb tug. Standardized berberine extracts muab tau los ntawm Coptis chinensis rhizome tau txawm raug tsim los ua lag luam tshuaj tua kab mob.
- Cov roj (cholesterol) thiab mob plawv
Ib lub cev loj ntawm kev tshawb fawb tau tshaj tawm tiasCoptis chinensis extract hmoov, tshwj xeeb tshaj yog berberine, tuaj yeem pab txo qis LDL thiab tag nrho cov roj cholesterol, nce HDL cholesterol, txo triglycerides hauv cov ntshav, thiab txo cov quav hniav hauv cov hlab ntsha. Qhov kev tiv thaiv kab mob plawv no tuaj yeem muaj txiaj ntsig zoo rau cov neeg mob hyperlipidemia, atherosclerosis, lossis cov neeg muaj kev pheej hmoo siab mob plawv thiab mob stroke [12]. Cov tswv yim pom zoo suav nrog kev txhawb nqa LDL receptor qhia, inhibiting lipid absorption hauv plab, thiab txo qis lipids synthesis hauv daim siab.
- Anti-Inflammatory
Cov tshuaj nyob rau hauv Coptis chinensis zoo li berberine thiab coptisine tau pom tias muaj peev xwm ua kom muaj zog tiv thaiv kab mob hauv lub cev nrog rau kev thaiv cov kab mob nuclear-kappa B (NF-kB), inhibiting cyclooxygenase -2 (COX-2), suppressing inflammatory cytokines zoo li qog necrosis factor-alpha (TNF-), interleukin 6 (IL-6), interleukin 1 beta (IL-1) thiab downregulating inflammatory enzymes xws li inducible nitric oxide synthase (iNOS). Qhov kev tiv thaiv kab mob dav dav no tuaj yeem ua tom qab ntau ntawm cov nroj tsuag kho cov ntawv thov los ntawm ntshav qab zib thiab kev zom zaub mov kom tswj tau kab mob.
- Antioxidant
Raws li cov nplua nuj ntawm berberine thiab lwm yam isoquinoline alkaloids, Coptis chinensis ua kom pom muaj zog antioxidant muaj peev xwm hauv kev tshem tawm cov pa oxygen reactive (ROS), txhawb nqa glutathione ntau lawm, thiab txo qis oxidative puas tsuaj rau lipids, proteins, thiab DNA. Qhov no pab tswj cov redox tshuav nyiaj li cas hauv cov hlwb thiab tiv thaiv oxidative kev nyuaj siab uas tsav cov kab mob. Cov dawb radical scavenging powers ua ke nrog kev ua haujlwm tiv thaiv kab mob kuj txhawb kev noj qab haus huv tag nrho.
- Neuroprotective
Qee qhov kev tshawb fawb tawm tshiab qhia tau hais tias Coptis chinensis tuaj yeem muab cov txiaj ntsig tiv thaiv kev noj qab haus huv los ntawm kev tiv thaiv cov neurons los ntawm toxicity-induced cell tuag, inhibiting zus tau tej cov amyloid beta proteins cuam tshuam rau Alzheimer's kab mob, thiab muaj peev xwm txhim kho kev txawj ntse los yog kev nco. Ib txoj kev tshawb fawb pom tau tias kev kawm tau zoo dua qub thiab kev nco hauv cov nas mob ntshav qab zib tau kho nrog Coptis chinensis berberine.
Risks thiab Side Effects
Thaum feem ntau suav hais tias muaj kev nyab xeeb rau kev siv sijhawm luv luv hauv cov koob tshuaj tsim nyog, Coptis chinensis tuaj nrog qee qhov kev pheej hmoo thiab cov kev mob tshwm sim los xav txog:
- Tsis tshua muaj, yuav txo cov ntshav qab zib ntau dhau rau cov neeg mob ntshav qab zib - yuav tsum tau saib xyuas ntau npaum li cas
- Muaj peev xwm cuam tshuam nrog cov tshuaj xws li ntshav thinners, tshuaj tua kab mob, tshuaj tiv thaiv kab mob lossis cov tshuaj tawg los ntawm CYP3A4 daim siab enzyme txoj hauv kev
- Cov koob tshuaj ntau tuaj yeem ua rau muaj teeb meem hauv plab hnyuv xws li xeev siab, raws plab, mob plab lossis cem quav.
- Tej zaum yuav ua rau muaj kev pheej hmoo ntawm embryotoxicity hauv cov poj niam cev xeeb tub
- Tsis haum rau cov me nyuam mos los yog me nyuam yaus vim muaj kev txhawj xeeb txog kev noj qab haus huv ntawm me nyuam mos
- Cov ntaub ntawv qhia txog kub taub hau, ua pa nyuaj siab, lossis txawm tias tsis nco qab nrog kev siv tshuaj ntau dhau hauv cov menyuam yaus
Vim muaj kev phiv thiab kev cuam tshuam, nws yog ib qho tseem ceeb uas yuav tau tham nrog koj tus kws kho mob ua ntej nojCoptis chinensis extract hmoov. Ceev faj thaum sib txuas nrog lwm yam tshuaj los yog tshuaj tshwj xeeb tshaj yog thaum cev xeeb tub los yog pub niam mis.
Kev txheeb xyuas thiab kev lees paub tseeb
Txhawm rau ua kom muaj kev tswj xyuas zoo rau cov kev npaj ib txwm muaj lossis kev kuaj mob niaj hnub nrog kev kwv yees lub zog ntawm cov tshuaj nquag, cov txheej txheem kev txheeb xyuas cov nroj tsuag kom raug yuav tsum tau ua [38]. Kev tshuaj ntsuam macroscopic thiab microscopic tso cai rau kev pom zoo ntawm cov cim qhia txog cov cim tseem ceeb xws li cov xim daj daj zoo li rhizome, cov qia hauv paus thiab nyias nyias. Cov txheej txheem tshuaj xws li kua chromatography thiab huab hwm coj spectrometry (LC-MS) profiling tom qab ntawd muab ntau qhov kev soj ntsuam ntawm cov khoom siv kos npe tshwj xeeb tshaj yog berberine rau cov qauv kev sib piv.
Genomic validation los ntawm DNA barcoding tsom xam kuj tau tshwm sim raws li ib txoj kev tshawb fawb muaj tseeb rau kev txheeb xyuas tus kheej taxonomic ntawm Coptis chinensis cov khoom siv. Kev kuaj DNA-raws li tso cai rau qhov sib txawv ntawm qhov tsis yog tsuas yog cov tsiaj sib txuas nkaus xwb tab sis kuj yog qhov sib txawv ntawm thaj chaw sib txawv uas tuaj yeem muaj qhov sib txawv me ntsis ntawm phytochemicals. Cov kev cai tseem tab tom hloov zuj zus, tab sis cov txheej txheem kev siv tau nruj dua yuav raug thov kom txhawb nqa kev kho mob raws li kev siv txuas ntxiv mus thoob ntiaj teb.
Cultivation Practices
Nyob rau hauv tej yam ntuj tso, nws yuav siv sij hawm 3 mus rau 5 xyoo rau cov qus Coptis chinensis kom ncav cuag kev loj hlob rau sau nrog lub siab tshaj plaws tshuaj potency thiab berberine ntsiab lus. Txawm li cas los xij, rau kev tsim khoom lag luam, cov neeg cog qoob loo siv ntau cov tswv yim txhawm rau txhawm rau txhawm rau biomass thiab bioactive tsub zuj zuj hauv kev tswj hwm ntau dua. Cov kev cog qoob loo feem ntau suav nrog kev sib tshuam nrog cov nroj tsuag ntxoov ntxoo, ntxiv cov chiv hloov kho kom haum rau kev nce isoquinoline alkaloid biosynthesis, thiab cov ntaub so ntswg kab lis kev cai micropropagation thaum xav tau chemotypes raug xaiv. Cov kev tshawb fawb txog kev ua liaj ua teb kuj tshawb xyuas seb yam xwm txheej zoo li lub caij sau qoob loo, cov txheej txheem ua kom qhuav tom qab sau qoob loo, thiab cov khoom cia tuaj yeem khaws cia bioactivity.
Kev sau qoob loo kom ruaj khov yog qhov tseem ceeb heev vim tias xyoo ntawm kev puas tsuaj cov tsiaj qus ua ke nrog cov vaj tse poob tau ua rau Coptis chinensis tam sim no tau teev npe nyob ze ze-kev hem thawj lossis tsis yooj yim rau cov nroj tsuag tshuaj uas xav tau kev txuag tseem ceeb. Txhawm rau tiv thaiv cov tsiaj qus ntxiv los ntawm kev ploj mus, kev cog qoob loo loj yog siv los ua kom tau raws li kev lag luam xav tau, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam tseem ceeb xws li xeev Sichuan, Tuam Tshoj uas suav txog ntau dua 50% ntawm cov txiaj ntsig thoob ntiaj teb. Organic certification cov kev pabcuam tseem tab tom tshwm sim los tsis yog txhawb nqa cov khoom siv xwb tab sis ua kom cov tshuaj muaj zog vim tias cov kev tshawb fawb pom tias bioactive sib txawv ntawm cov qauv kev loj hlob ntawm cov pa thiab cov organic loj tuaj yeem khi rau microbial zej zog kev sib cuam tshuam hauv cov av rhizosphere.
Hauv Summary
Coptis chinensis yog ib qho tshuaj ntsuab uas muaj npe nrov hauv Suav teb uas tau siv los kho cov kab mob, txhawb kev zom zaub mov noj qab haus huv, tswj ntshav qab zib, thiab tiv thaiv kev noj qab haus huv tag nrho ntau txhiab xyoo. Kev tshawb fawb niaj hnub no tau pib nthuav tawm cov txheej txheem tom qab bioactivity ntawm cov nroj tsuag no thiab paub meej tias muaj ntau yam kev siv ib txwm siv xws li tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob antioxidant kom muaj peev xwm tawm tsam cov kab mob xws li Alzheimer's thiab kab mob plawv. Berberine sawv cev rau ib qho tseem ceeb phytochemical constituent harboring tiv thaiv los ntawm ntau yam kab mob. Txawm li cas los xij cov qauv tsim tawm, kev txheeb xyuas kom raug, thiab kev tiv thaiv kev nyab xeeb yog qhov tsim nyog kom tsis txhob muaj tshuaj lom lossis tsis zoo cuam tshuam nrog cov tshuaj xws li cov ntshav thinners. Los ntawm kev sib koom ua ke ob qho tib si thaum ub thiab kev tshawb fawb tsis tu ncua, Coptis chinensis thiab cov txiaj ntsig tseem ceeb xws li berberine tseem nyob ntawm tus thawj coj ntawm kev tsim cov tshuaj kho tshiab los ntawm lub tsev muag tshuaj los tawm tsam kev kis tus kab mob loj zuj zus mus rau xyoo pua 21st.
Txais tos xa email rau peb yog tias koj txaus siab rauCoptis Chinensis Extract hmoovNtawmSales@Kintaibio.Com.
Cov ntaub ntawv
[1] Wu, JN Ib Daim Duab Qhia Suav Materia Medica. Oxford University Press. Xyoo 2005.
[2] Kev tshuaj ntsuam xyuas ntawm coptis chinensis franch inflorescences. Zhongguo Zhong yao za zhi=Zhongguo zhongyao zazhi=Tuam Tshoj phau ntawv journal ntawm Suav materia medica. Xyoo 1999.
[3] Coptis chinensis. Elsevier Science. Xyoo 2005.
[4] Zhou J., et al. Coptis chinensis vs antimicrobial resistance: Kev tshuaj xyuas. Suav Tshuaj. 2022
[5] Cov txheej txheem muaj peev xwm rau cov teebmeem ntawm Coptidis Rhizoma thiab berberine ntawm IBD. Inflammatory plob tsis so tswj kab mob. 2018.
[6] Berberine: Tus Kws Kho Mob Novel rau Kab Mob plab thiab Hepatobiliary. Cov ntaub ntawv pov thawj-raws li cov tshuaj ntxiv thiab lwm yam tshuaj: eCAM. 2020
[7] Kev ua tau zoo ntawm berberine nyob rau hauv cov neeg mob uas tsis yog-alcoholic fatty siab kab mob: ib qho kev ntsuam xyuas meta. PloS ib. 2019
[8] Multitargeted mechanisms hauv qab lub endothelial tiv thaiv los ntawm cov ntshav qab zib-safesweetener rebaudioside A. Arteriosclerosis, thrombosis, thiab vascularbiology. 2013
[9] Berberine inhibits kev loj hlob thiab inducesapoptosis ntawm tib neeg cov kab mob zes qe menyuam. Oncology qhia. Xyoo 2014
