yees extract

Yew Extract yog muab rho tawm los ntawm cov nroj tsuag tsis tshua muaj yew. Nws nplooj, stems, bark, thiab cov hauv paus hniav muaj taxine diterpenoids ua lub ntsiab Cheebtsam, yewine, yewine A, yewine H, thiab yewine K, paclitaxel L, taxine, golden Pine flavonoid, ponasterone A, ecdysterone, golden ntoo thuv biflavone, volatile roj, taxane, polysaccharide, tannin, tannin, thiab lwm yam, kuj muaj lwm yam polyphenols thiab amino acids, lignans, inorganic ntsiab. Paclitaxel muaj cov tshuaj tiv thaiv kab mob leukemia thiab qog nqaij hlav.

Taxus chinensis extract yog dej extract lossis cawv extract ntawm cov tshuaj suav tshuaj Taxus chinensis, thiab nws cov tshuaj tseem ceeb yog paclitaxel, diterpenoid compound. Nws muaj anti-tumor thiab anti-cancer teebmeem.

1). Cov dej solubility suav txog li 50%, suav nrog polysaccharides, tannins, phenols, polysaccharides, amino acids, inorganic ntsiab thiab lwm yam khoom.
2). Cov tshuaj xws li tannin uas yog insoluble hauv dej thiab organic solvents suav txog li 33%.
3). Muaj 17% rog-soluble ib feem, noj paclitaxel raws li cov khoom siv, uas suav nrog cov seganes thiab muaj cov tebchaw xws li tricyclic diterpenes thiab lignans.

1). Chromatographic tej yam kev mob

Chromatographic kem: μ-Bondapak C18 kem (300mm × 3.9mm, 10μm); mobile theem: methanol-acetonitrile-dej-tetrahydrofuran (15:40:40:5); Tus nqi ntws: 1.2ml / min; Kem kub: 30 ± 1 degree.

2). Kev npaj cov ntawv xeem

Noj li ntawm 12mg ntawm cov khoom no, ua tib zoo ntsuas nws hauv Chemicalbook, muab tso rau hauv 100ml ntsuas lub raj mis, ntxiv 55ml ntawm methanol-acetonitrile (3:8) tov kuab tshuaj, co tag nrho kom tag nrho yaj paclitaxel, ces ntxiv dej-tetrahydrofuran (8. : 1) sib tov Cov kuab tshuaj tau diluted mus rau lub cim, thiab cov tshuaj saum toj no tau noj ntau npaum li cas, centrifuged rau 5 feeb, thiab cov supernatant raug coj los txiav txim raws li cov xwm txheej ntawm cov qauv no, thiab cov txiaj ntsig tau pom hauv daim duab hauv qab no.

HPLC daim ntawv qhia ntawm Taxus Chinensis Extract

1 cephalomannine; 2 paclitaxel ua

1). Anti-tumor nyhuv
Taxol, qhov tseem ceeb tshaj plaws los tiv thaiv qog nqaij hlav ntawm Taxus Chinensis Extract hmoov, muaj peb lub tswv yim ntawm kev ua:
① Microtubule depolymerization stabilization mechanism: Paclitaxel tuaj yeem cuam tshuam kev faib ntawm Hela hlwb hauv theem logarithmic. Los ntawm kev khi rau tubulin dawb, nws inhibits lub depolymerization ntawm tsim microtubules, thaiv lub voj voog ntawm tes, ua rau txawv txav lossis cuam tshuam mitosis, thiab rhuav tshem cov hlwb. Lub dynamic regeneration ntawm microtubule system tsim nyog rau mitosis thiab interphase ua rau qog cell replication thiab tuag.
②Immune mechanism: Zoo ib yam li lub luag hauj lwm ntawm cov kab mob polysaccharide (LPS), nws activates macrophages, ua rau txo cov qog necrosis factor (TNF-) receptors thiab tso tawm TNF-, tua los yog inhibiting qog hlwb.
③ Induce cancer cell apoptosis: ua rau Fas/Fasl txoj kev ntawm apoptosis receptor pathway, los yog qhib lub cysteine ​​protease system kom induce apoptosis.

2). Anti-inflammatory nyhuv

3). Kev tiv thaiv daim siab
Ob flavonoids, ginkgetin, thiab sciadopitysin, cais los ntawm methanol extract ntawm yew twigs, tuaj yeem cuam tshuam qhov kev tsim dua tshiab ntawm phosphatase (PRL-3) hauv daim siab mob hlwb. Qhov no tuaj yeem muab txoj hauv kev tshiab los kawm cov tshuaj tiv thaiv qog noj ntshav los ntawm kev tswj PRL-3- kho kom haum rau ib channel.

4). Antihypertensive thiab hypoglycemic nyhuv
Taxol cais tawm los ntawm Taxus chinensis muaj cov haujlwm tseem ceeb los tiv thaiv ntshav qab zib thiab tsis muaj tshuaj lom, yog li nws muaj kev tshawb fawb zoo thiab kev txhim kho thiab kev cia siab rau daim ntawv thov.

5). Anti-oxidation, tshem tawm cov dawb radicals
Yew extract yog cais los ntawm lub plawv thiab cov hauv paus hniav ntawm yew. Los ntawm kev sim hauv vitro, nws tau pom tias nws muaj zog antioxidant thiab dawb radical scavenging teebmeem, tuaj yeem ua tau zoo ntawm ntau yam kev puas tsuaj ntawm cov hlab plawv, thiab muaj cov toxicity tsawg thiab tsis muaj kev phiv.

Yew, tseem hu ua Suav cypress ntoo thuv, yew, thiab ntshav cypress ntoo thuv, yog cov nroj tsuag ntawm genus Taxus hauv tsev neeg Taxaceae. Muaj 11 hom yew nyob rau hauv lub ntiaj teb no, faib nyob rau hauv temperate mus rau tropical cheeb tsam ntawm sab qaum teb hemisphere. Muaj 4 hom thiab 1 ntau yam nyob rau hauv Suav teb, xws li Suav yew, northeast yew, Yunnan yew, yav qab teb yew, Tibetan yew, thiab lwm yam., faib nyob rau hauv Northeast Tuam Tshoj, South Tuam Tshoj thiab Southwest Tuam Tshoj.

Yew yog ib hom ntoo qub uas tau tso tseg los ntawm Quaternary glacier.Nws tau raug teev tseg raws li lub ntiaj teb cov nroj tsuag tsis tshua muaj thiab muaj kev puas tsuaj thiab lub ntiaj teb sab saum toj kaum hom kab mob. Nws yog lub teb chaws thawj-chav tiv thaiv ntoo hom thiab yog lub npe hu ua "Plant Giant Panda". Cov av thiab huab cua nyob rau hauv peb lub nroog yog haum rau kev loj hlob ntawm yew yav qab teb. Raws li kev tshawb fawb ua ntej, cov yew yav qab teb tau nthuav dav hauv cov tsiaj qus hauv peb lub nroog, nrog ntau tshaj 500,000 cov nroj tsuag, thiab muaj ntau txhiab tsob nroj hauv zej zog (xws li tsib tsob ntoo hauv Huashan Forest Farm. . Baiguo, Shangsifang, thiab lwm yam), cov nroj tsuag loj tshaj plaws muaj ib txoj kab uas hla ntawm 164 cm, thiab plaub tus neeg tuav tsis tau ua ke. Nws yog tsob ntoo uas muaj hnub nyoog txhiab xyoo. Nws muaj luxuriant ceg thiab tawm txhua lub caij nplooj zeeg, thiab nws yog ib qho tsis tshua pom.

Xyoo 1971, cov kws tshuaj Asmeskas tau tshawb pom thawj zaug thiab muab cov tshuaj tiv thaiv kab mob qog noj ntshav thiab kho mob qog noj ntshav paclitaxel ntawm cov nroj tsuag yew. Raws li cov ntaub ntawv tseem ceeb, paclitaxel tuaj yeem txhim kho txoj kev ncig thiab kev ua haujlwm metabolic ntawm tib neeg lub cev, thiab tshem tawm cov kab mob hauv tib neeg lub cev los ntawm lub cev los ntawm diuresis thiab defecation. , tiv thaiv mob qog noj ntshav; Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam cov mitosis ntawm cov qog nqaij hlav cancer, yog li tiv thaiv kev loj hlob ntawm cov qog nqaij hlav cancer. Nws muaj txiaj ntsig zoo rau kev mob qog noj ntshav prostate, mob qog noj ntshav hauv plab, mob qog noj ntshav ntawm zes qe menyuam, mob qog noj ntshav hauv tsev menyuam, mob qog noj ntshav duct, thiab muaj qee yam cuam tshuam rau lwm cov qog nqaij hlav cancer. Inhibition, hu ua "kab kawg ntawm kev tiv thaiv hauv kev mob qog noj ntshav siab". Yew tseem muaj ntau dua 90 hom khoom xyaw uas tib neeg lub cev xav tau, uas tuaj yeem txhim kho tib neeg kev tiv thaiv kab mob thiab muaj peev xwm tiv thaiv kab mob, txo cov ntshav qabzib ntau hauv cov neeg mob hyperglycemia, thiab muaj cov txiaj ntsig tseem ceeb ntawm cov ntshav siab.

2）Kintai R&D Center

3) Kintai Hoobkas

★ yees extractyog ib qho ntawm peb cov khoom tseem ceeb, thiab peb muaj Tshuag txaus, yog tias koj xav tau, txais tos hu rau peb ntawm email, E-mail:cheney@kintaibio.com

Cim npe nrov: Yew Extract, Tuam Tshoj Yew Extract manufacturers, lwm tus neeg, Hoobkas