Ampelopsin

KINTAI Ampelopsin, AMP yog ib qho chaw sib cais los ntawm cov nplooj ntawm cov nroj tsuag ntuj Ampelopsis meliaefolia ( Tes. -Mazz.) WT Wang, thiab cov ntsiab lus AMP hauv cov nplooj qub yog siab li 37.4% mus rau 38.5%. Peb tsuas yog tsim 98% Dihydromyricetin (Ampelopsin). Cov tshuaj no yog polyphenolic hydroxyl dihydroflavonol compound thiab tuaj yeem siv dav hauv cov khoom siv tshuaj.

Ampelopsis Grossedentata (Vine tshuaj yej)

98% Dihydromyricetin (Ampelopsin)

Cov kev tshawb fawb tau pom tias ntxiv rau cov khoom siv dav dav ntawm flavonoids xws li kev tiv thaiv daim siab, antioxidant, thiab tshuaj tua kab mob, AMP kuj muaj cov nyhuv inhibiting qog ua haujlwm xws li mob qog noj ntshav, mob qog noj ntshav, thiab qog noj ntshav ntawm zes qe menyuam, thiab muaj kev txhim kho cov ntshav siab, hyperlipidemia, thiab ntshav qab zib txawv txawv. Tsis ntev los no, cov kev tshawb fawb tau pom tias nws tseem muaj kev tiv thaiv zoo neuroprotective tiv thaiv Alzheimer's kab mob, AD, Parkinson's disease, PD, kev quav dej caw, thiab kev nyuaj siab.

DHM FACTORY cov ntaub ntawv muaj!

Ampelopsin chaw tsim tshuaj paus qauv puab ntim cov ntsiab lus

1. Anti-inflammatory, analgesic thiab antibacterial teebmeem
Lub 98% Ampelopsin peb muab rho tawm los ntawm rattan tshuaj yej muaj cov tshuaj tua kab mob tseem ceeb. Cov kev tshawb fawb tshuaj niaj hnub no tau pom tias nws muaj qhov cuam tshuam tseem ceeb hauv kev sim ntau yam kab mob, suav nrog cocci, bacilli, kab mob Gram-positive thiab Gram-negative bacteria, thiab kuj muaj qee yam inhibitory nyhuv ntawm cov poov xab thiab pwm. Nyob rau tib lub sijhawm, raws li qhov concentration ntawm dihydromyricetin nce, cov nyhuv antibacterial nce. Nws tsuas yog ua haujlwm los ntawm inhibiting qhov kev tso tawm ntawm cov teeb meem inflammatory interleukin 1, IL-1, interleukin-6 (IL-6) thiab qog necrosis factor, TNF- los ntawm lipopolysaccharide, LPS-induced macrophages RAW264. 7. Tsis tas li ntawd, cov kev tshawb fawb tau pom tias AMP txo qis qhov o ntawm nas pob ntseg o kev sim. Thaum siv los ua zaub mov preservative, nws qhia tau hais tias cov zaub mov preservative nyhuv zoo dua li benzoic acid.

RCov ntaub ntawv: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804380/

2. Cov nyhuv tiv thaiv qog

Cov ntaub ntawv:https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1160548/full

2.1 Mob qog noj ntshav:

① Upregulate ERK1/2, p38 protein kinase, JNK los yog p53 protein kinase phosphorylation, tswj MMP-9 los yog Bax/Bcl-2 signaling, inhibit qhov adhesion, migration thiab ntxeem tau ntawm daim siab mob hlwb, thiab induce qog hlav. cell apoptosis;

② Inhibit LC3-II thiab Bcl{1}} qhia, inhibit mTOR activation, thiab induce autophagy los ntawm ERK1/2, AMPK thiab PI3K/PDK1/Akt signaling pathways;

③ Induce G2 / M cell voj voog raug ntes los ntawm kev txo CDK1 kev ua, inhibit qog cell proliferation thiab sib txawv;

④ Downregulate Notch1 qhia, induce qog cell autophagy thiab apoptosis;

⑤ Downregulate Akt qhia thiab Ser473 site phosphorylation theem, inhibit Bad Ser136 thiab Ser112 site phosphorylation, Bcl-2 qhia, txhawb caspase-3 cleavage activation, thiab induce qog cell apoptosis;

⑥ Induce qog cell apoptosis los ntawm TGF- taw qhia txoj hauv kev, thiab ua si tiv thaiv kab mob qog noj ntshav.

2.2 Mob cancer mis:Thaum ntxov hauv vitro kev sim pom tau tias Ampelopsin ntxias PTEN demethylation hauv tib neeg lub mis mob qog noj ntshav MCF-7, txo MCF-7 cell viability nyob rau hauv ib koob tshuaj, thiab zoo inhibited sai proliferation thiab metastasis ntawm cov qog nqaij hlav cancer. Qhov rhiab heev ntawm cov qog nqaij hlav cancer mis rau dihydromyricetin yog MDA-MB-231MCF-7/A＞MCF-7. Ampelopsin ua rau Bcl-2 thiab chemokine receptor type 4 (CXCR4), caspase-3/9, thiab Bcl{12}} inhibits kev loj hlob ntawm cov qog nqaij hlav hauv lub mis, kev tsiv teb tsaws thiab kev cuam tshuam los ntawm mTOR txoj kev taw qhia.
 

2.3 Cov qog nqaij hlav zes qe menyuam:Cov kev tshawb fawb tau pom tias dihydromyricetin concentration dependently downregulates IAPs tsev neeg protein Survivin, induces cell apoptosis thiab activates autophagy-txog teeb liab txoj kev, inhibiting qhov sib txawv ntawm zes qe menyuam qog noj ntshav A2780 thiab SKOV3.
 

2.4 Lwm yam mob qog noj ntshav:Cov kev tshawb fawb tau pom tias AMP tseem tuaj yeem cuam tshuam kev tsim N-nitrosamines thiab kev loj hlob ntawm PC-3 prostate cancer hlwb los ntawm kev tshem tawm cov carcinogen nitrite. AMP tseem tuaj yeem cuam tshuam qhov ua kom ntawm caspase-3 thiab caspase-9 thiab txhawb nqa Bcl-2 txhawm rau tiv thaiv apoptosis los ntawm oxidative kev nyuaj siab hauv osteosarcoma hlwb MG63.

3. Cov nyhuv neuroprotective

Cov ntaub ntawv:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057232/

3.1 Alzheimer's Disease (AD):Ib txoj kev tshawb fawb hauv 2012 pom tias AMP tuaj yeem ua raws li GABA A receptor allosteric modulator nyob rau hauv lub hauv paus paj hlwb, tswj lub cev muaj nuj nqi ntawm GABA A receptors raws li ib tug modulator ntawm GABA A receptors. Tsis tas li ntawd, nyob rau hauv txoj kev tshawb no ntawm AD gene qauv nas, nws tau pom tias AMP zoo txo ​​cov deposition ntawm -amyloid protein nyob rau hauv lub hlwb ntawm AD qauv nas thiab rov qab qhia cov postsynaptic GABA A receptor thauj tog rau nkoj protein gephyrin, uas ncaj qha tswj kev tsim. thiab hloov kho ntawm GABAergic synapses, yog li kho qhov inhibitory postsynaptic txawv txav hluav taws xob ua haujlwm kho los ntawm GABA A receptors ntawm cov neurons hauv hippocampal cingulate gyrus, thiab txhim kho lub cev muaj zog thiab kev paub tsis meej ntawm AD qauv nas.

3.2 Tus kab mob Parkinson (PD):Cov kev tshawb fawb ua ntej tau pom tias AMP ntawm koob tshuaj 5 lossis 10 mg / kg tuaj yeem txhim kho kev coj tus cwj pwm tsis zoo hauv PD qauv nas raug ntxias los ntawm 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine thiab MPTP. Nws tuaj yeem cuam tshuam Akt/glycogen synthase kinase 3 , Akt/GSK-3 qhia txoj hauv kev, txo qhov tsim cov pa oxygen dawb radicals, thiab yog li thaiv dopaminergic neuron puas los ntawm MPTP.

3.3 Kev nyuaj siab:Los ntawm LPS-induced nas kev nyuaj siab qauv thiab mob ntev unpredictable me ntsis kev nyuaj siab, CUMS cov kev tshawb fawb tau pom tias Ampelopsin tuaj yeem txo cov kev nyuaj siab thiab kev xav ntawm tus nas ib txwm muaj thiab LPS-induced depression model nas, thiab alleviate the depressive-like behavior of CUMS model nas. Cov nyhuv no muaj feem xyuam rau dihydromyricetin activating cAMP- teb cov ntsiab lus binding protein, CREB signaling, GSK-3 Ser-9 site phosphorylation, upregulating BDNF qhia thiab inhibiting inflammatory teb. .

3.4 Kev haus dej cawv:Cov kev tshawb fawb tau pom tias AMP tuaj yeem tiv thaiv kev ua siab ntev, kev ntxhov siab thiab tus cwj pwm zoo li qaug dab peg los ntawm kev haus cawv ntau dhau. Cov teebmeem saum toj no tuaj yeem thaiv los ntawm benzodiazepine antagonist flumazenil. Nws cov txheej txheem zoo sib xws rau AMP qhov kev sib tw inhibition ntawm qhov chaw ua haujlwm ntawm benzodiazepines ntawm GABA A receptors. Yog li ntawd, nws yog feem ntau siv los txo cov cawv vim kev ua siab ntev thiab kev ntxhov siab.

4. Lwm yam teebmeem ntawm lub cev
4.1 Antioxidant:Cov kev tshawb fawb tau pom tias AMP tuaj yeem txo qhov kev qhia ntawm miR-34a hauv hippocampus ntawm D-galactose-induced aging model nas. MiR-34a muaj feem cuam tshuam nrog cov kab mob kev laus. Yog li, nws tuaj yeem txhim kho lub cev muaj peev xwm antioxidant thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative.
 

4.2 Kev tswj hwm metabolic:Nws qhia txog cov txiaj ntsig ntawm kev txo cov ntshav qab zib thiab txhim kho cov tshuaj insulin hauv cov qauv ntshav qab zib.
Kev tiv thaiv daim siab: Txo daim siab puas thiab muaj peev xwm tiv taus daim siab fibrosis thiab cirrhosis.
 

4.3 Kev tiv thaiv raum:AMP tuaj yeem txo cov kev raug mob raum molecular -1, KIM-1 thiab cov ntshav urea hauv cov nas endotoxemia, txo cov ntsiab lus ntawm malondialdehyde thiab calcium ion concentration hauv cov ntaub so ntswg, thiab txo cov mob raum. Kev ntsuam xyuas cov ntaub so ntswg hauv lub raum qhia tau tias Ampelopsin tuaj yeem txo cov calcium oxalate crystals thiab tubular dilatation, thiab muaj qee yam kev tiv thaiv thiab kev kho mob ntawm lub raum pob zeb.

Cov ntaub ntawv:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754091/

5. Kev tiv thaiv kab mob
Kev sib xyaw ua ke ntawm dihydromyricetin thiab myricetin nthuav tawm dav-spectrum tshuaj tiv thaiv kab mob, suav nrog lub peev xwm tiv thaiv kab mob siab B, kab mob khaub thuas thiab tus mob coronavirus, thiab tuaj yeem tiv thaiv kab mob HIV ntawm lub hom phiaj.

Cov kev tshawb fawb tsis ntev los no ntawmAmpelopsintau pom tias nws muaj peev xwm dav hauv pharmacology, tshwj xeeb tshaj yog nyob rau hauv cov nqe lus ntawm kev sib cuam tshuam nrog lwm yam tshuaj. Cov kev sib cuam tshuam no tuaj yeem tsis tsuas yog txhim kho nws cov bioavailability tab sis kuj txhim kho cov teebmeem ntawm cov tshuaj chemotherapeutic, uas muaj qhov tseem ceeb hauv kev kho mob.

Cov ntaub ntawv:https://www.drugs.com/drug-interactions/dimenhydrinate, dmh.html

1. Txhim kho bioavailability
Lub bioavailability ntawm dihydromyricetin Ampelopsin yog tsawg, tsuas yog 4.02% tom qab kev tswj qhov ncauj. Qhov kev txwv no txwv nws cov txiaj ntsig hauv kev siv tshuaj kho mob. Txhawm rau daws qhov teeb meem no, cov kws tshawb nrhiav pom tias calcium channel blocker verapamil, uas yog P-glycoprotein inhibitor, tuaj yeem txhim kho bioavailability ntawm dihydromyricetin. Tshwj xeeb, verapamil tuaj yeem txhim kho cov ntshav siab tshaj plaws (Cmax) thiab thaj chaw hauv qab cov tshuaj concentration-lub sij hawm nkhaus (AUC) ntawm dihydromyricetin, nce nws cov bioavailability rau 6.84%. Qhov kev cuam tshuam no qhia tau hais tias verapamil tuaj yeem tsis tsuas yog txhim kho kev nqus ntawm dihydromyricetin, tab sis tseem ncua nws cov txheej txheem metabolic hauv daim siab, yog li txhim kho nws cov tshuaj pharmacological.

2. Kev cuam tshuam ntawm cov tshuaj metabolism
Nembutal yog ib qho uas nquag siv sedative-hypnotic, thiab nws cov metabolism feem ntau nyob ntawm lub siab CYP enzyme system. Cov kev tshawb fawb tau pom tias Ampelopsin tuaj yeem ncua sijhawm pw tsaug zog ntawm pentobarbital thiab txhim kho nws cov nyhuv sedative. Qhov no qhia tau hais tias nws yuav txhim khu lub hauv paus inhibitory nyhuv ntawm pentobarbital los ntawm inhibiting cov kev ua ntawm daim siab CYP enzymes.

3. Txhim khu kev ua tau zoo ntawm cov tshuaj chemotherapy
Ua ke nrog doxorubicin:Doxorubicin yog ib qho dav-spectrum tshuaj tiv thaiv qog, tab sis nws cardiotoxicity yog ib qho teeb meem loj hauv kev kho mob. Kev tshawb fawb tau pom tias dihydromyricetin tuaj yeem txo qis doxorubicin-vim mob plawv, txo cov ntshav aspartate aminotransferase (AST), lactate dehydrogenase (LDH) thiab creatine kinase MB (CKMB) cov dej num, thiab yog li txhim kho myocardial muaj nuj nqi. Nyob rau tib lub sijhawm, dihydromyricetin tuaj yeem txhim kho qhov rhiab heev ntawm cov qog hlwb rau doxorubicin thiab txo nws txoj kev kho kom zoo. Qhov kev tshawb pom no muab lub tswv yim tshiab rau kev siv tshuaj kho mob ntawm doxorubicin, thiab nws tuaj yeem txo cov kev mob tshwm sim los ntawm kev sib xyaw dihydromyricetin.

Ua ke nrog streptozotocin:Streptozotocin feem ntau yog siv los kho cov tshuaj insulinoma, tab sis nws siv mus ntev yuav ua rau mob ntshav qab zib. Txoj kev tshawb nrhiav pom tias qhov sib ntxiv ntawm AMP tuaj yeem thim rov qab cov tsos mob ntshav qab zib uas tshwm sim los ntawm streptozotocin, txhim kho lub cev hnyav thiab cov ntshav qab zib hauv cov nas, thiab txhim kho mitochondrial muaj nuj nqi. Cov txiaj ntsig no qhia tau tias cov khoom xyaw ntuj no muaj peev xwm siv tau rau hauv kev kho mob ntshav qab zib mellitus.

Ua ke nrog cisplatin:Cisplatin yog ib qho khoom siv hlau platinum los tiv thaiv qog nqaij hlav, tab sis nws qhov kev puas tsuaj rau ob lub raum feem ntau txwv nws daim ntawv thov kho mob. AMP tuaj yeem txhim kho cisplatin-vim lub raum puas tsuaj los ntawm inhibiting oxidative stress, inflammatory teb thiab cell apoptosis, yog li txhim kho nws txoj kev nyab xeeb thiab ua tau zoo.

Ua ke nrog nedaplatin:nedaplatin muaj cytotoxic thiab radiosensitizing teebmeem, tab sis nws kuj muaj teeb meem tshuaj tiv thaiv. AMP ua ke nrog nedaplatin tuaj yeem txhim kho cov tshuaj kho mob rhiab heev ntawm daim siab mob qog noj ntshav thiab txo cov cytotoxicity ntawm nedaplatin, muab cov muaj peev xwm tshiab rau kev kho mob qog noj ntshav.

★ Yog tias koj xav tau cov khoom zooAmpelopsin, thov koj xav tiv tauj peb ntawmsales@kintaibio.com los yogtawm tswv yim nyob rau nplooj ntawv tom ntej.

Cim npe nrov: ampelopsin, Tuam Tshoj ampelopsin manufacturers, lwm tus neeg, Hoobkas